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leizhong.bsky.social
@leizhong.bsky.social
40 followers 86 following 4 posts
PhD in @Suessmuth_lab, TU Berlin. Research on structural elucidation and biosynthesis of bioactive secondary metabolites (NRPs/PKs) from 🦠.
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hendersonlab.bsky.social
Ian Henderson @hendersonlab.bsky.social · 28d
Want to know what natural products are in clinical trials? Read this review! Great job from Mark Butler, Rob Capon, Mark Blaskovich! pubs.rsc.org/en/content/a...

#naturalproducts #antibiotic #amr #drugdiscovery #drug
Natural product-derived compounds in clinical trials and drug approvals
Covering: January 2014–June 2025. Previous review: Natural Product Reports, 2014, 31, 1612Natural products (NPs) have long been foundational in medicine, from ancient herbal remedies to the discovery ...
pubs.rsc.org
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leizhong.bsky.social
leizhong.bsky.social @leizhong.bsky.social · Jul 4
#Suessmuth_Lab #Synpepbio
We are delighted and grateful to see our recent work highlighted on the #American_Peptide_Society website.
americanpeptidesociety.org/aps-news/pot...
Potent Antifungal Lipopeptide
Potent Antifungal Lipopeptide
americanpeptidesociety.org
leizhong.bsky.social
leizhong.bsky.social @leizhong.bsky.social · Jun 3
#SüssmuthLab We have investigated the structure, bioactivity, and biosynthesis of AFC-BC11, an antifungal lipopeptide whose structure has remained unresolved since its discovery in 1998. Just published in JACS (@jacs.acspublications.org):
#NaturalProduct #Antifungal 🇩🇪🇫🇷
The Intricate Nonribosomal Assembly of a Potent Antifungal Lipopeptide from the Burkholderia cepacia Complex
The Burkholderia cepacia complex (BCC) is a group of Gram-negative bacteria known for their pathogenicity to patients suffering from cystic fibrosis (CF). The BCC-belonging strain B. pyrrocinia BC11 (...
pubs.acs.org
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niedermeyer-lab.bsky.social
Timo Niedermeyer @niedermeyer-lab.bsky.social · May 22
Interested in natural product producing microorganisms? 🦠 See you in Berlin... 😀
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leizhong.bsky.social
leizhong.bsky.social @leizhong.bsky.social · May 3
Our new paper is out! In collaboration with Flavia Marinelli’s and Oleksandr Yushchuk’s groups, we report the discovery of Kineomicin, a novel glycopeptide antibiotic featuring a unique scaffold: Hpg at AA1 and isoleucine at AA3. #antibiotics #naturalproducts
commschem.nature.com
Communications Chemistry @commschem.nature.com · May 3
Just out: A rare peptide scaffold in kineomicins, the glycopeptide antibiotics produced by Actinokineospora auranticolor DSM 44650
A rare peptide scaffold in kineomicins, the glycopeptide antibiotics produced by Actinokineospora auranticolor DSM 44650
Communications Chemistry, Published online: 03 May 2025; doi:10.1038/s42004-025-01534-xThe rise of bacterial resistance necessitates the discovery of novel antibiotics, particularly the last-resort glycopeptide antibiotics (GPAs). Here, the authors identify a unique biosynthetic gene cluster in Actinokineospora auranticolor, leading to the discovery of kineomicins, a new class of GPAs with high production potential.
bit.ly
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leizhong.bsky.social
leizhong.bsky.social @leizhong.bsky.social · Feb 11
New Review Article

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

onlinelibrary.wiley.com/share/M8VFCW...
Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research
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onlinelibrary.wiley.com
Reposted
natrevmicro.nature.com
Nature Reviews Microbiology @natrevmicro.nature.com · Jan 17
New online! Microbial secondary metabolites: advancements to accelerate discovery towards application
Microbial secondary metabolites: advancements to accelerate discovery towards application
Nature Reviews Microbiology, Published online: 17 January 2025; doi:10.1038/s41579-024-01141-yIn this Review, Dinglasan and colleagues explore innovations that facilitate rapid microbial secondary metabolite discovery, focusing on recent techniques for…
go.nature.com
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Reposted
wildtypemc.bsky.social
Marc Chevrette @wildtypemc.bsky.social · Jan 12
~5y ago, Barbara, Serina, @marnixmedema.bsky.social & I teamed up to make a better NRPS A-domain specificity predictor. The Challis group & others joined along the way to add some very cool insights.

Very proud of this work. Check it out now on biorxiv!

doi.org/10.1101/2025...
PARAS: high-accuracy machine-learning of substrate specificities in nonribosomal peptide synthetases
Nonribosomal peptides are chemically and functionally diverse natural products with important applications in medicine and agriculture. Bacterial and fungal genomes contain thousands of nonribosomal p...
doi.org
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Reposted
jjjvanderhooft.bsky.social
Justin J.J. van der Hooft @jjjvanderhooft.bsky.social · Nov 22
#Symposium #Omics #Mining #Wageningen @WUR
Join @marnixmedema and myself to 🎉 celebrate 🎉 10 years of genome mining and 5 years of metabolome mining in Wageningen! #Computational #Genomics #Metabolomics #CompMetabolomics

www.linkedin.com/posts/jjjvan...
Justin J.J. van der Hooft on LinkedIn: #wageningen #campus #computational #genomics #metabolomics…
🚨 Symposium Announcement & Invitation 🚨 On March 26th, 2025, Marnix Medema and myself will organise a symposium in the Omnia building of the #Wageningen…
www.linkedin.com
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