lek-lab.bsky.social
LEK Lab
@lek-lab.bsky.social
270 followers 220 following 8 posts
Laboratory of Prof. Lewis E. Kay at the University of Toronto | Nuclear Magnetic Resonance of biomolecules | Est. 1992
Posts Media Videos Starter Packs
Reposted by LEK Lab
irinabezsonova.bsky.social
Irina Bezsonova @irinabezsonova.bsky.social · 16d
Our latest paper is online today ahead of print in PNAS
@pnas.org

www.pnas.org/doi/10.1073/...
Functional spectrum of USP7 pathogenic variants in Hao–Fountain syndrome: Insights into the enzyme’s activity, stability, and allosteric modulation | PNAS
Hao–Fountain syndrome is a rare neurodevelopmental disorder caused by mutations in the deubiquitinating enzyme Ubiquitin-Specific Protease 7 (USP7)...
www.pnas.org
4 11
Reposted by LEK Lab
ciccheminst.bsky.social
Chemical Institute of Canada @ciccheminst.bsky.social · Sep 3
The CSC and CSChE societies and communities express deep concern over proposed Tri-Council funding cuts. Canada must invest in science to ensure long-term health, innovation, and prosperity. Read the full statement here: buff.ly/peiCUfk
buff.ly
3 3
Reposted by LEK Lab
nmr900.bsky.social
Magnetic Resonance News @nmr900.bsky.social · Aug 31
Journal of Molecular Biology (open) Review Article, Application of NMR to Large RNAs, Brian D. Grossman, Jan Marchant*, Michael F. Summers* www.sciencedirect.com/science/arti... #NMRchat 🧲
Application of NMR to Large RNAs
Heteronuclear NMR methodologies developed over the past 40 years have enabled atomic level insights into the solution-state structure and dynamics of …
www.sciencedirect.com
2 4
Reposted by LEK Lab
roesslph.bsky.social
Philip Rößler @roesslph.bsky.social · Aug 31
New paper from the Gossert lab: Dynamic interactions in the human β1AR signalling complex with mini-Gs revealed by NMR www.sciencedirect.com/science/arti...
Dynamic interactions in the human β1AR signalling complex with mini-Gs revealed by NMR
A wealth of insights into the mechanisms of GPCRs have been gained from biophysical studies of thermostabilized β1 adrenergic receptors (β1AR) from tu…
www.sciencedirect.com
2 9
Reposted by LEK Lab
cryoempapers.bsky.social
cryoEM papers @cryoempapers.bsky.social · Aug 27
Allosteric regulation of proteolytic machines unveiled by the synergy between cryo-EM and solution NMR spectroscopy pubmed.ncbi.nlm.nih.gov/40857152/ #cryoem
4 3
Reposted by LEK Lab
biophysicalsoc.bsky.social
Biophysical Society @biophysicalsoc.bsky.social · Aug 27
Get important feedback from your community and move your work forward. Share your research at #bps2026!

Submit an abstract today buff.ly/oOjstk6
BPS2026 Annual Meeting | Biophysical Society
The BPS2026 Annual Meeting in San Francisco will showcase Biophysics by the Bay, highlighting the exciting advances in science and technology brought forth by big data and AI.  This year’s program…
www.biophysics.org
7 12
Reposted by LEK Lab
nmr900.bsky.social
Magnetic Resonance News @nmr900.bsky.social · Aug 19
How a small lab @cicbiogune.bsky.social led by Óscar Millet, took on one of the world’s rarest diseases www.the-scientist.com/modeling-ang... #NMRnews #NMRchat #NMR 🧲
1 2
Reposted by LEK Lab
hillerlab.bsky.social
HillerLab @hillerlab.bsky.social · Aug 11
New paper alert! Stellar work by brilliant lead first author @annaleder.bsky.social together with project leader @masgu.bsky.social reveals a groundbreaking discovery: PDIA6 forms multi-chaperone condensates creating "folding factories" in the ER. www.nature.com/articles/s41...
2 16 43
Reposted by LEK Lab
nmr900.bsky.social
Magnetic Resonance News @nmr900.bsky.social · Aug 8
Nature Communications (open) Seedless: on-the-fly pulse calculation for NMR experiments, Charles J. Buchanan, Gaurav Bhole, Gogulan Karunanithy, Virginia Casablancas-Antràs, Adeline W. J. Poh, Benjamin G. Davis, Jonathan A. Jones* & Andrew J. Baldwin* www.nature.com/articles/s41... #NMRchat #NMR 🧲
Seedless: on-the-fly pulse calculation for NMR experiments - Nature Communications
The authors develop a computational tool to design NMR pulses, based on the GRadient Assisted Pulse Engineering approach, that can calculate optimal pulse shapes on the fly during the measurements, to...
www.nature.com
3 7
Reposted by LEK Lab
scisonja.bsky.social
Sonja Schmid @scisonja.bsky.social · Jul 31
#3: #PhD Position on Structure–Dynamics–Function Relationship of the #Chaperone #Hsp90:

➤ NMR spectroscopy for atomic-resolution
➤ Single-molecule FRET for time-resolved dynamics
Collab.: @hillerlab.bsky.social & Schmid lab @unibas.ch

More info & online application system: tinyurl.com/mr2em3nk
3 10
Reposted by LEK Lab
scisonja.bsky.social
Sonja Schmid @scisonja.bsky.social · Jul 31
💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭:
#nanopores #smFRET #biomolecular #dynamics #singleMolecules

We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech.

Please share broadly, thank you!🤝

schmid.chemie.unibas.ch
Home | Research Group Schmid | University of Basel
schmid.chemie.unibas.ch
2 31 35
Reposted by LEK Lab
nmr900.bsky.social
Magnetic Resonance News @nmr900.bsky.social · Jul 28
on behalf of Professor James Keeler (University of Cambridge) considering the possibility of revising the text and creating a third edition : Understanding NMR Spectroscopy, James Keeler - survey concerning a possible third edition cambridge.eu.qualtrics.com/jfe/form/SV_... #NMRbooks #NMRchat #NMR 🧲
book cover
4 10
Reposted by LEK Lab
nature.com
Nature @nature.com · Jul 31
Nature research paper: Diffusing protein binders to intrinsically disordered proteins

go.nature.com/4lSCdzE
Diffusing protein binders to intrinsically disordered proteins - Nature
Using RFdiffusion, a general method for targeting intrinsically disordered proteins and regions for protein design has been developed.
go.nature.com
9 20
Reposted by LEK Lab
nmrkaygee.bsky.social
Kevin Gardner @nmrkaygee.bsky.social · Jul 30
Absolutely outrageous interference in NIH extramural funding by OMB dropping this evening. Damaging to our nation’s world leadership, innovation, and training today and for years in the future. www.wsj.com/politics/pol...
Trump Administration Puts New Chokehold on Billions in Health-Research Funding
The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.
www.wsj.com
3 20 23
Reposted by LEK Lab
cicbiogune.bsky.social
CIC bioGUNE @cicbiogune.bsky.social · Jul 24
#bioGUNE_Talent | 👏 Óscar Millet #CICbioGUNE @brtaeus.bsky.social, appointed Vice President of @group-ampere.bsky.social, Europe’s top #NMR organization, the first Spanish scientist to hold this role

🎉 Congratulations, Óscar!

🔗 ow.ly/hxi450Wuwiw
6 12
Reposted by LEK Lab
friedrichlab.bsky.social
Daniel Friedrich @friedrichlab.bsky.social · Jul 22
Great #NMR work on PTMs of histones by @roesslph.bsky.social and colleagues at @lek-lab.bsky.social!
roesslph.bsky.social
Philip Rößler @roesslph.bsky.social · Jul 22
Fresh off the press from the @lek-lab.bsky.social: Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation
#NMRchat
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
2 5
lek-lab.bsky.social
LEK Lab @lek-lab.bsky.social · Jul 22
Check it out!
roesslph.bsky.social
Philip Rößler @roesslph.bsky.social · Jul 22
Fresh off the press from the @lek-lab.bsky.social: Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation
#NMRchat
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
1 4
Reposted by LEK Lab
paczkowskilab.bsky.social
Jon Paczkowski🌹 @paczkowskilab.bsky.social · Jul 16
I am (optimistically) looking for a postdoc with solution state biomolecular NMR expertise to join our group. I can provide access to high-end instrumentation and technical assistance via our membership at the New York Structural Biology Center. #nmr #academicsky #postdoc
5 3
Reposted by LEK Lab
nmr900.bsky.social
Magnetic Resonance News @nmr900.bsky.social · Jul 16
Tenure Track Professor of Structural Biology of Emerging Drug Targets at Medical University of Graz www.medunigraz.at/en/job-openi... #NMRjobs #NMRchat #NMR 🧲
Tenure track professorships
www.medunigraz.at
2 3
Reposted by LEK Lab
irinabezsonova.bsky.social
Irina Bezsonova @irinabezsonova.bsky.social · Jun 16
New publication alert!
Using NMR we show how the C-tail of USP7 contributes to its activation by facilitating ubiquitin release.

Online today in Journal of Molecular Biology.

www.sciencedirect.com/science/arti...
The C-Terminal Tail of Ubiquitin-Specific Protease 7 Facilitates Ubiquitin Release and Ensures Efficient Catalytic Turnover
USP7 is a key ubiquitin-specific protease involved in human development. Its activity is regulated by an intramolecular interaction between the cataly…
www.sciencedirect.com
2 4
Reposted by LEK Lab
fitzkeelab.bsky.social
Nicholas Fitzkee @fitzkeelab.bsky.social · Jun 9
Good heavens. How are we supposed to do NMR when D2O prices are north of $1,500/L?
6 3 8
Reposted by LEK Lab
nmrkaygee.bsky.social
Kevin Gardner @nmrkaygee.bsky.social · Jun 9
Please join me and >5000 others in supporting NIH staff in their work supporting US biomedical research! actionnetwork.org/forms/add-na...
ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff
Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.
actionnetwork.org
1 9
Reposted by LEK Lab
fosterlab.bsky.social
MP Foster Lab @ The Ohio State University @fosterlab.bsky.social · May 28
Fun to celebrate inauguration of the National Gateway Ultrahigh Field NMR Center at Ohio State with the 1.2 GHz Bruker Ascend Spectrometer @osuchembiochem.bsky.social #nmr @brukercorporation.bsky.social
Group of scientists cutting red ribbon with large red scissors in front of a large 1.2 GHz NMR instrument.
1 3 11
Reposted by LEK Lab
irinabezsonova.bsky.social
Irina Bezsonova @irinabezsonova.bsky.social · May 24
link.growkudos.com/1e2aa2yse0w

USP7 spotlight
How a Key Enzyme Switches On and Off—And How a Rare Mutation Pushes It Into Overdrive
USP7 is an important enzyme whose activity is tightly controlled in cells. Using advanced NMR techniques, researchers gained a rare glimpse into how the enzyme’s movements regulate its function. They ...
link.growkudos.com
2 3
Reposted by LEK Lab
nmr900.bsky.social
Magnetic Resonance News @nmr900.bsky.social · May 5
@natchem.nature.com Leveraging relaxation-optimized 1H–13CF correlations in 4-19F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins www.nature.com/articles/s41... #NMRchat #NMR 🧲
Leveraging relaxation-optimized 1H–13CF correlations in 4-19F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins - Nature Chemistry
Correlating aromatic carbons attached to fluorine with meta-position hydrogens in fluorine-labelled phenylalanines can yield two-dimensional correlations with narrow linewidths in large proteins. Adap...
www.nature.com
1 3