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lexiong.bsky.social
Le Xiong
@lexiong.bsky.social
30 followers 130 following 4 posts
Mucosal Immunology PhD candidate @WEHI
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iuis-online.bsky.social
International Union of Immunological Societies @iuis-online.bsky.social · Jun 25
Introducing Andy Gao, postdoctoral fellow at John Curtin School of Medical Research, ANU! He will present his research on T & B cell collaboration in vaccination & parasite infection at #IUIS2025, with the presentation "Can a B cell eat a parasite? 🔬🌍
https://loom.ly/CwagY2g
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Reposted by Le Xiong
seilletlab.bsky.social
Cyril Seillet, PhD @seilletlab.bsky.social · Jun 2
🎓 PhD positions available @MonashUni
Join our lab to explore how neurons and immune cells shape gut immunity!
🧬 Single-cell RNAseq
🔬 3D imaging
🧠 Neuro-immune interactions
👥 Great mentoring & collaborations

Apply now 👉 tinyurl.com/Seilletlab
Understanding the neuroimmune regulation of innate immunity | Supervisor Connect
tinyurl.com
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lexiong.bsky.social
Le Xiong @lexiong.bsky.social · Jun 17
Congratulations !!!
xingaoimmunology.bsky.social
Xin(Andy) Gao @xingaoimmunology.bsky.social · Jun 17
I'm honoured to be recognized as one of the IUIS 2025 Rising Stars. Thanks to ASI for the nomination. Looking forward to seeing everyone in Vienna!
#IUIS2025 #RisingStars2025
iuis.org/news/meet-th...
Meet the IUIS 2025 Rising Stars! » IUIS
The International Union of Immunological Societies (IUIS), together with its Early Career Committee, is delighted to announce the outstanding researchers selected as the IUIS 2025 Rising Stars: This…
iuis.org
Reposted by Le Xiong
wehi-research.bsky.social
WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · May 19
A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health.

Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity.

www.wehi.edu.au/news/fast-fo...
Innate lymphoid cells 3 (ILC3s) are a subset of immune cells that are critical to gut immunity. When there is excess fat, such as after a rich meal, ILC3s store this fat in tiny lipid droplets to maintain their function. In this 3D illustration, we can see a lipid droplet (in orange) inside an ILC3.
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lexiong.bsky.social
Le Xiong @lexiong.bsky.social · May 18
Excited to see our work published on @cp-immunity.bsky.social.
Also shared by a nice commentary. really like the last sentence:
“Not all fuel nourishes; some, once ignited, may burn beyond control.”
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Reposted by Le Xiong
lozanzi.bsky.social
Ivan Zanoni @lozanzi.bsky.social · Apr 19
#WeekendRead! #NotAllFatIsEqual! @lexiong.bsky.social Seillet &co show @cp-immunity.bsky.social that #diet saturated fatty acids rapidly impair (while unsaturated fatty acids favor via lipid droplets) IL22 production by ILC3 supporting dysbiosis & gut permeability, exacerbating inflammation!
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...
www.cell.com
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Reposted by Le Xiong
wehi-research.bsky.social
WEHI (The Walter and Eliza Hall Institute of Medical Research) @wehi-research.bsky.social · May 7
Future vaccines a step closer. Research from @groomlab.bsky.social, @benjbroom.bsky.social and team use novel approach and mRNA tech to boost stem cell-like memory CD8+ T cells after vaccination.

Published in @jem.org

www.wehi.edu.au/news/vaccine...
A visualisation of immune cells, with headline "Long-lasting vaccines of the future a step closer"
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lexiong.bsky.social
Le Xiong @lexiong.bsky.social · Apr 15
Saturated long-chain fatty acids suppress ILC3 function and increase gut inflammation, while unsaturated ones sustain IL-22 production through lipid droplets formation
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lexiong.bsky.social
Le Xiong @lexiong.bsky.social · Apr 15
Thrilled to share our work now published on @cp-immunity.bsky.social . Big thanks to our collaborators. Here we show that short-term High-Fat diet impairs ILC3 functions in producing IL-22 through microbiota-dependent and-independent mechanisms.
cp-immunity.bsky.social
Immunity @cp-immunity.bsky.social · Apr 14
Online now: Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (ILC3s) is impaired, compromising gut barrier integrity. Saturated fatty acids intrinsically suppress ILC3 function, reducing their ability to control gut inflammation.
dlvr.it
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Reposted by Le Xiong
benjbroom.bsky.social
Benjamin Broomfield @benjbroom.bsky.social · Mar 17
Happy one week of my @jem.org paper!

Our work from the @groomlab.bsky.social at @wehi-research.bsky.social identifies using early IFN-I blockade alongside mRNA vaccination to direct CD8+ T cell positioning in the lymph node to drive Tscm cell differentiation and enhance vaccine protection
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Reposted by Le Xiong
jem.org
Journal of Experimental Medicine @jem.org · Mar 10
@benjbroom.bsky.social et al. @groomlab.bsky.social show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cell–like memory CD8+ T cells rupress.org/jem/article/...
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