Laboratory of Genomic Stability
@lgs-imb.bsky.social
330 followers 710 following 4 posts
Institute of Molecular Biology, BAS #DNArepair #Replication #Genomeintegrity #Cancer #Anticancerdrugs #Microscopy
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Reposted by Laboratory of Genomic Stability
natcellbio.nature.com
👋Our April issue's out!
Cover: Live #chromosome tracking

👉🏼Perspective on #lactylation
👉🏼Review on #MechanicalForces in development
🔬 #MyocardialInfarction #PreclinicalStudy #NeuralStemCells #proteostasis #neurodegeneration #mitochondria #CellDeath #cancer & more!
www.nature.com/ncb/volumes/...
Chromosomes in rainbow colors inside blue nuclei on a black background
lgs-imb.bsky.social
I would like to be added. Thanks!
Reposted by Laboratory of Genomic Stability
fenaochs.bsky.social
Hi Bluesky! I made a 3D chromatin starter pack.
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ
Reposted by Laboratory of Genomic Stability
andersshansen.bsky.social
Excited to share James Jusuf's preprint:

By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%)

We quantify mESC 36k loops: are generally rare (2.3%)

www.biorxiv.org/content/10.1...
lgs-imb.bsky.social
Here we can see how #centrosome motion contributes directly to chromosome redistribution.
lgs-imb.bsky.social
Dynamics of intra- and inter- chromosomal contacts during mitosis with 8-second resolution
lgs-imb.bsky.social
We’re excited to share our work where we investigated the mechanisms of chromosome motion by tracking all #chromosomes, mapping their interactions, and live cell karyotyping, using #AI based denoising, segmentation and registration, published in Nature Cell Biology.
www.nature.com/articles/s41...