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LinderLab @linderlab.bsky.social · 26d

New preprint:
Phagocytic podosomes enable efficient uptake of Candida auris by primary human macrophages 🦠👄
www.biorxiv.org/content/10.1...

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LinderLab @linderlab.bsky.social · Sep 4

You´re welcome. Podosomes show oscillatory growth (pubmed.ncbi.nlm.nih.gov/31836688/) and thus repeatedly dip into the extracellular matrix (ECM).

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LinderLab @linderlab.bsky.social · Sep 2

Our paper on podosome regulation by myosins 1e/f is now online.
We introduce the concept of the podosome base, a region of plasma membrane-associated components 🔬
Cool collaboration with @renaudpoincloux.bsky.social‬ and Krendel labs
www.sciencedirect.com/science/arti...

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LinderLab @linderlab.bsky.social · Aug 26

Congratulations to our lab member Bryan Barcelona to a super fancy defense on software-based analysis of cell and podosome parameters 👨‍🎓

LinderLab @linderlab.bsky.social · Aug 25

Lycanthia von Tanith Lee

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LinderLab @linderlab.bsky.social · Jul 9

Cellular fireworks
(in a primary human macrophage):
Microtubule +tips, labeled by CLIP170-GFP, move from the microtubule organizing center (MTOC) to the cell periphery ✨

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Reposted by LinderLab

Pablo J. Sáez @pjsaez.bsky.social · Jul 8

This is why we love #cellmigration

#Leukocytes: #Neutrophils (cyan) #Macrophages (orange) chemotaxis.

I couldn't share it before the retirement of @zebrafishrock.bsky.social, but cool #microscopy in #zebrafish continue to rock !

#scicomm #scisky @cellcommlab.bsky.social @focalplane.bsky.social 🧪🔬

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LinderLab @linderlab.bsky.social · Jul 4

A warm welcome to our new master student Mahmood Tarmom, who will work on podosome proteins of (yet) unknown function 🔬

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LinderLab @linderlab.bsky.social · Jun 23

Coming up: "Live Biological Imaging Across Scales", part of the Royal Microscopic Society line of Wiley books.
Featuring 10 chapters from international experts on live imaging from molecules to organisms.
Edited by Claire M. Wells and yours truly 📘🧬🐭

LinderLab @linderlab.bsky.social · Apr 30

Our preprint on podosome regulation by unconventional myosins in now on BioRxiv. Great collaboration with the @renaudpoincloux.bsky.social and Krendel labs.
www.biorxiv.org/content/10.1...

We introduce the concept of the "podosome base", a region of plasma membrane-associated podosome components.

Myo1e (green) shows a more ventral localization than the F-actin core (red) of podosomes. XZ side view of two podosomes.

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Reposted by LinderLab

Tom Gauld @tomgauld.bsky.social · Apr 28

My latest @newscientist.com cartoon

Title:
SOME GRAMMATICAL VOICES FOR USE IN SCIENTIFIC WRITING

ACTIVE VOICE
e.g.
Our team collected samples and then we tested them.

CLICKBAIT VOICE
e.g.
We collected some samples...
You won't believe what happened next!

PASSIVE VOICE
e.g.
Samples were collected and tested.

HAIKU VOICE
e.g.
Quiet science lab.
Workers arrive with samples.
The testing begins.

PASSIVE-AGGRESSIVE VOICE
e.g. We did all the collecting and testing.
No need to thank us.
Just doing our job.

CONSPIRACY VOICE
e.g.
Mysterious "Samples" were harvested and covertly "tested" by so-called scientists.

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Reposted by LinderLab

Aymelt Itzen @itzenlab.bsky.social · Apr 24

Interesting preprint from the Windhorst, Marlovits and Linder (@linderlab.bsky.social) groups: They investigate the spectrum of actin binding motives that may exist in many proteins.
www.biorxiv.org/content/10.1...

Discovery of a new evolutionarily conserved short linear F-actin binding motif

Regulation of the actin cytoskeleton by actin binding proteins (ABPs) is essential for cellular homeostasis, and the mode of actin binding determines the activity of ABPs. Here, we discovered a novel ...

www.biorxiv.org

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LinderLab @linderlab.bsky.social · Apr 14

Interested in cutting edge Microscopy Techniques?
Check out the latest special issue of Journal of Microscopy, edited by yours truly 🔬
onlinelibrary.wiley.com/toc/13652818...

Special Issue: Microscopy Techniques: Journal of Microscopy: Vol 298, No 2

The <em>Journal of Microscopy</em> is the oldest journal dedicated to the science of microscopy, publishing the latest advances in microscopy techniques and novel areas of application.

onlinelibrary.wiley.com

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Reposted by LinderLab

RTG2771 Humans and Microbes @rtg2771.bsky.social · Apr 11

🧑‍🎓👩‍🎓We are hiring:

PhD student positions in Molecular Infection Biology
in DFG Research Training Group Humans and Microbes
@cssbhamburg.bsky.social @leibnizliv.bsky.social @bosse-lab.bsky.social @linderlab.bsky.social @itzenlab.bsky.social #UKE #UHH #BNITM

📬Apply until June 20, 2025.
grk2771.de

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LinderLab @linderlab.bsky.social · Apr 9

Upcoming meeting:
11th Trippenhuis meeting of the Dutch Society for Cell Biology
(Amsterdam, May 8-9) 🏠

LinderLab @linderlab.bsky.social · Apr 8

We are hiring!
The DFG-funded RTG2771 training group is offering PhD positions in molecular infection biology for 3-4 years
For more information, see grk2771.de
(our lab is project 4) 👨‍🎓

RTG 2771 – Humans and Microbes – Reorganization of Cell Compartments and Molecular Interactions during Infection

grk2771.de

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LinderLab @linderlab.bsky.social · Apr 1

Farewell sushi dinner for our longtime assistant Andrea who is now retiring 🥲🍣

LinderLab @linderlab.bsky.social · Mar 10

Congratulations to our lab member Rawan Batlouni for an excellent MD thesis on phagocytic podosomes 👨‍🎓

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LinderLab @linderlab.bsky.social · Feb 26

A warm welcome to our new MD student Fan Yang, who will work on Borrelia-macrophage interaction 🤗

LinderLab @linderlab.bsky.social · Feb 21

Video of a FIB-SEM analysed macrophage phagosome containing a single Borrelia cell being compacted by membrane tubulation, leading to reduction of the phagosome volume.
Phagosome membrane in blue, Borrelia in turquoise. Watch for start of transparency mid-video 🪱
pubmed.ncbi.nlm.nih.gov/33380490/

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Reposted by LinderLab

RTG2771 Humans and Microbes @rtg2771.bsky.social · Feb 3

Registration and abstract submission for our International Symposium Cell and Structural Biology of Host Pathogen Interaction from 10 – 12 Sept 2025 @cssbhamburg.bsky.social in Hamburg, Germany are now open.

✅ Register here: express.converia.de/frontend/ind...
💡More info: humansandmicrobes2025.de

Humans and Microbes 2025 – Symposium Cell and Structural Biology of Host Pathogen Interaction

humansandmicrobes2025.de

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Reposted by LinderLab

RTG2771 Humans and Microbes @rtg2771.bsky.social · Jan 29

🚨 Save the date! 🚨
We're thrilled to announce our International Symposium on Cell & Structural Biology of Host-Pathogen Interaction
📅 Sept 10-12, 2025
📍
@cssbhamburg.bsky.social Hamburg

Registration starts soon
For more info:
humansandmicrobes2025.de

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LinderLab @linderlab.bsky.social · Jan 30

New account, new publication:
Our video article on building your own tumor spheroid-macrophage coinvasion assay is now online 🎤
review.jove.com/de/t/67374/a...

A Macrophage-Tumor Spheroid Co-Invasion Assay | Protocol

Scientific Article | Here, we present a protocol to investigate the interaction of primary human monocyte-derived macrophages with a tumor spheroid in a...

review.jove.com