@liuyongxin.bsky.social
Reposted
Antioxidants promote metabolic remodeling in cattle rumen epithelium revealed by single‐cell resolution 🐄https://onlinelibrary.wiley.com/doi/10.1002/imt2.70100
Antioxidants promote metabolic remodeling in cattle rumen epithelium revealed by single‐cell resolution
Single-cell and transcriptomics from 1.79 million cells identify the forestomach epithelium as the dominant site of antioxidant activity and oxidative phosphorylation (OXPHOS) in the bovine gastroint...
onlinelibrary.wiley.com
January 5, 2026 at 1:09 PM
Antioxidants promote metabolic remodeling in cattle rumen epithelium revealed by single‐cell resolution 🐄https://onlinelibrary.wiley.com/doi/10.1002/imt2.70100
Reposted
🧪 Nanoplastic exposure disrupts bile acid metabolism and gut microbiota, driving systemic metabolic collapse.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction
The pervasiveness of microplastic pollution poses a growing health risk, yet its long-term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanopartic...
onlinelibrary.wiley.com
January 5, 2026 at 1:16 PM
🧪 Nanoplastic exposure disrupts bile acid metabolism and gut microbiota, driving systemic metabolic collapse.
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted
Network perturbation analysis identifies new molecular subtypes of endometrial cancer
💫Three distinct subtypes show different clinical outcomes.
onlinelibrary.wiley.com/doi/10.1002/...
💫Three distinct subtypes show different clinical outcomes.
onlinelibrary.wiley.com/doi/10.1002/...
Network Perturbation Analysis Identifies Three Molecular Subtypes With Distinct Clinical Outcomes and Therapeutic Vulnerabilities in Endometrial Cancer
We performed network perturbation analysis on transcriptomic data from endometrial cancer patients across multiple cohorts and identified three molecular subtypes with distinct clinical outcomes. The...
onlinelibrary.wiley.com
December 23, 2025 at 12:39 PM
Network perturbation analysis identifies new molecular subtypes of endometrial cancer
💫Three distinct subtypes show different clinical outcomes.
onlinelibrary.wiley.com/doi/10.1002/...
💫Three distinct subtypes show different clinical outcomes.
onlinelibrary.wiley.com/doi/10.1002/...
Reposted
⚡️Gut microbes and liver metabolism collaborate to fight fatty liver!
⚙️ Cetobacterium somerae converts arginine to putrescine, which the liver transforms into spermidine to reduce hepatic lipid accumulation.
onlinelibrary.wiley.com/doi/10.1002/...
⚙️ Cetobacterium somerae converts arginine to putrescine, which the liver transforms into spermidine to reduce hepatic lipid accumulation.
onlinelibrary.wiley.com/doi/10.1002/...
Host‐driven hepatic conversion of gut microbiota‐derived putrescine to spermidine mediates mannose's protective effects against hepatic steatosis in zebrafish
Evidence for liver metabolism of gut-derived microbial compounds into beneficial secondary metabolites has been lacking. Here, we demonstrate that Cetobacterium somerae (C. somerae), enriched by mann....
onlinelibrary.wiley.com
December 22, 2025 at 10:43 AM
⚡️Gut microbes and liver metabolism collaborate to fight fatty liver!
⚙️ Cetobacterium somerae converts arginine to putrescine, which the liver transforms into spermidine to reduce hepatic lipid accumulation.
onlinelibrary.wiley.com/doi/10.1002/...
⚙️ Cetobacterium somerae converts arginine to putrescine, which the liver transforms into spermidine to reduce hepatic lipid accumulation.
onlinelibrary.wiley.com/doi/10.1002/...
Reposted
🧬Single-cell spatial transcriptomics reveals potential molecular mechanisms of Abelmoschus manihot (L.) medic in treating diabetic kidney disease
#scRNAseq #MolecularMechanisms #iMeta onlinelibrary.wiley.com/doi/10.1002/...
#scRNAseq #MolecularMechanisms #iMeta onlinelibrary.wiley.com/doi/10.1002/...
Single‐cell spatial transcriptomics reveals potential molecular mechanisms of Abelmoschus manihot (L.) medic in treating diabetic kidney disease
A clinical study reported that Abelmoschus manihot (L.) Medic (A. manihot), in the form of Huangkui capsule (HKC), combined with irbesartan (IRB) is an effective therapy for patients with diabetic ki...
onlinelibrary.wiley.com
December 10, 2025 at 12:09 PM
🧬Single-cell spatial transcriptomics reveals potential molecular mechanisms of Abelmoschus manihot (L.) medic in treating diabetic kidney disease
#scRNAseq #MolecularMechanisms #iMeta onlinelibrary.wiley.com/doi/10.1002/...
#scRNAseq #MolecularMechanisms #iMeta onlinelibrary.wiley.com/doi/10.1002/...
Reposted
🫁Immune–transcriptomic profiling uncovers a four-gene model AUC 0.94 for lung cancer with pulmonary tuberculosis!
💡#MTB remodels #tumor #microenvironment via metabolic-immune crosstalk.
⚡First #immune-transcriptomic map of #lung cancer plus tuberculosis.
onlinelibrary.wiley.com/doi/10.1002/...
💡#MTB remodels #tumor #microenvironment via metabolic-immune crosstalk.
⚡First #immune-transcriptomic map of #lung cancer plus tuberculosis.
onlinelibrary.wiley.com/doi/10.1002/...
Immunometabolic Features and Key Biomarkers in Lung Cancer Complicated by Pulmonary Tuberculosis: Insights From Transcriptome and Clinical Cohort Analysis
Integrative analysis of LC-PTB patients pinpoints six biomarkers (ANK2, EPB42, CA1, HBB, HBD, MYL4) that reshape the immune microenvironment, offering new targets for diagnosis and treatment of lung ...
onlinelibrary.wiley.com
December 7, 2025 at 7:29 AM
🫁Immune–transcriptomic profiling uncovers a four-gene model AUC 0.94 for lung cancer with pulmonary tuberculosis!
💡#MTB remodels #tumor #microenvironment via metabolic-immune crosstalk.
⚡First #immune-transcriptomic map of #lung cancer plus tuberculosis.
onlinelibrary.wiley.com/doi/10.1002/...
💡#MTB remodels #tumor #microenvironment via metabolic-immune crosstalk.
⚡First #immune-transcriptomic map of #lung cancer plus tuberculosis.
onlinelibrary.wiley.com/doi/10.1002/...
Reposted
🧠 Copper exposure drives #neurotoxicity through a gut–brain metabolic axis!
🔥 It triggers #gut barrier damage and inflammation, leading to #neural injury.
💊 The #probiotic W. coagulans XY2 counteracts toxicity by targeting a multi-layered network.
onlinelibrary.wiley.com/doi/10.1002/...
🔥 It triggers #gut barrier damage and inflammation, leading to #neural injury.
💊 The #probiotic W. coagulans XY2 counteracts toxicity by targeting a multi-layered network.
onlinelibrary.wiley.com/doi/10.1002/...
Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk
Copper interferes with tryptophan metabolism and 5-HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coag...
onlinelibrary.wiley.com
December 7, 2025 at 7:44 AM
🧠 Copper exposure drives #neurotoxicity through a gut–brain metabolic axis!
🔥 It triggers #gut barrier damage and inflammation, leading to #neural injury.
💊 The #probiotic W. coagulans XY2 counteracts toxicity by targeting a multi-layered network.
onlinelibrary.wiley.com/doi/10.1002/...
🔥 It triggers #gut barrier damage and inflammation, leading to #neural injury.
💊 The #probiotic W. coagulans XY2 counteracts toxicity by targeting a multi-layered network.
onlinelibrary.wiley.com/doi/10.1002/...
Reposted
Travel to China allowed me to meet again previous PhD and guest PhD students in my group, Yicen, Xinli, Guohai, and Jiyu and my collaborator, Zhihui
October 29, 2025 at 8:37 PM
Travel to China allowed me to meet again previous PhD and guest PhD students in my group, Yicen, Xinli, Guohai, and Jiyu and my collaborator, Zhihui
Reposted
🚀 #iMeta is reshaping academic communication!
📲 Multi-platform + bilingual strategy expands global reach.
📈 1.36M full-text downloads, >10K citations, IF 33.2 (2024)!
🌐 New sub-journals & events foster a vibrant research ecosystem.
🔗 doi.org/10.1002/imt2...
#Journal
📲 Multi-platform + bilingual strategy expands global reach.
📈 1.36M full-text downloads, >10K citations, IF 33.2 (2024)!
🌐 New sub-journals & events foster a vibrant research ecosystem.
🔗 doi.org/10.1002/imt2...
#Journal
iMeta: Boosting academic sharing and collaboration via social media
Social media platforms have revolutionized scientific communication by bridging gaps between researchers, academic journals, and global audiences. This article showcases iMeta, an open-access journal...
doi.org
October 21, 2025 at 2:15 PM
🚀 #iMeta is reshaping academic communication!
📲 Multi-platform + bilingual strategy expands global reach.
📈 1.36M full-text downloads, >10K citations, IF 33.2 (2024)!
🌐 New sub-journals & events foster a vibrant research ecosystem.
🔗 doi.org/10.1002/imt2...
#Journal
📲 Multi-platform + bilingual strategy expands global reach.
📈 1.36M full-text downloads, >10K citations, IF 33.2 (2024)!
🌐 New sub-journals & events foster a vibrant research ecosystem.
🔗 doi.org/10.1002/imt2...
#Journal
Reposted
💡 30 scientific recommendations from the #CHINAGUT Conference!
👩🔬 63 experts joined forces to shape the future of:
🦠 #Probiotics
💊 Live biotherapeutic products
💩 #FMT
The goal: standardization, regulation & precision in #microbiome-based therapies.
🔗 doi.org/10.1002/imt2...
👩🔬 63 experts joined forces to shape the future of:
🦠 #Probiotics
💊 Live biotherapeutic products
💩 #FMT
The goal: standardization, regulation & precision in #microbiome-based therapies.
🔗 doi.org/10.1002/imt2...
October 22, 2025 at 3:26 PM
💡 30 scientific recommendations from the #CHINAGUT Conference!
👩🔬 63 experts joined forces to shape the future of:
🦠 #Probiotics
💊 Live biotherapeutic products
💩 #FMT
The goal: standardization, regulation & precision in #microbiome-based therapies.
🔗 doi.org/10.1002/imt2...
👩🔬 63 experts joined forces to shape the future of:
🦠 #Probiotics
💊 Live biotherapeutic products
💩 #FMT
The goal: standardization, regulation & precision in #microbiome-based therapies.
🔗 doi.org/10.1002/imt2...
Reposted
🌱 What shapes the chemotypes of Atractylodes lancea?
Not genes alone!
🧬 Genetic divergence follows altitude & climate.
🌾 #Soil and #microbiome together tune its metabolite profiles.
🦠 Core #rhizosphere & endophytic microbes hold the key.
🔗 doi.org/10.1002/imo2...
Not genes alone!
🧬 Genetic divergence follows altitude & climate.
🌾 #Soil and #microbiome together tune its metabolite profiles.
🦠 Core #rhizosphere & endophytic microbes hold the key.
🔗 doi.org/10.1002/imo2...
The combined influence of microbiome and soil environment contributes to the chemotype differentiation in Atractylodes lancea
Genetic differentiation between the Maoshan-Dabie Mountains group (MA genotype) and Qinling-Taihang Mountains group (SA genotype) of Atractylodes lancea occurs along altitude and climatic gradients. ....
doi.org
October 22, 2025 at 3:08 PM
🌱 What shapes the chemotypes of Atractylodes lancea?
Not genes alone!
🧬 Genetic divergence follows altitude & climate.
🌾 #Soil and #microbiome together tune its metabolite profiles.
🦠 Core #rhizosphere & endophytic microbes hold the key.
🔗 doi.org/10.1002/imo2...
Not genes alone!
🧬 Genetic divergence follows altitude & climate.
🌾 #Soil and #microbiome together tune its metabolite profiles.
🦠 Core #rhizosphere & endophytic microbes hold the key.
🔗 doi.org/10.1002/imo2...
Reposted
Tidyplots empowers life scientists with easy code‐based data visualization
onlinelibrary.wiley.com/doi/full/10....
#Bioinformatics #R #Rstudio #visualization
onlinelibrary.wiley.com/doi/full/10....
#Bioinformatics #R #Rstudio #visualization
Tidyplots empowers life scientists with easy code‐based data visualization
Effective data visualization is vital for analyzing and communicating experimental results. However, most code-based plotting tools require substantial programming experience, posing a significant ba....
onlinelibrary.wiley.com
March 20, 2025 at 8:56 AM
Tidyplots empowers life scientists with easy code‐based data visualization
onlinelibrary.wiley.com/doi/full/10....
#Bioinformatics #R #Rstudio #visualization
onlinelibrary.wiley.com/doi/full/10....
#Bioinformatics #R #Rstudio #visualization
Reposted
Gut microbial‐derived 3,4‐dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome onlinelibrary.wiley.com/doi/10.1002/...
#galactosidase #PCOS #microbiome #DHPAA
#galactosidase #PCOS #microbiome #DHPAA
Gut microbial‐derived 3,4‐dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome
By integrating multi-level and multi-omics analyses, we identify 3,4-dihydroxyphenylacetic acid (DHPAA), a gut microbiota-derived degradation product of dietary flavonoids, as a key bioactive end-pro...
onlinelibrary.wiley.com
July 28, 2025 at 7:51 AM
Gut microbial‐derived 3,4‐dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome onlinelibrary.wiley.com/doi/10.1002/...
#galactosidase #PCOS #microbiome #DHPAA
#galactosidase #PCOS #microbiome #DHPAA
Reposted
Yongxin Liu from Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, AGIS introduction iMeta (@imetascience.bsky.social) as Executive Editor of the journal
#BGIspatialmicrobiome
#BGIspatialmicrobiome
October 22, 2025 at 3:20 AM
Yongxin Liu from Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, AGIS introduction iMeta (@imetascience.bsky.social) as Executive Editor of the journal
#BGIspatialmicrobiome
#BGIspatialmicrobiome