Long COVID Signal
@longcovidsignal.bsky.social
Tracking the latest Long COVID research so you don't have to.
NET biomarkers (immune cell traps) were comprehensively analyzed in COVID-19 and long COVID patients in analysis.
📄 https://pubmed.ncbi.nlm.nih.gov/41627524/
📄 https://pubmed.ncbi.nlm.nih.gov/41627524/
February 2, 2026 at 11:13 PM
NET biomarkers (immune cell traps) were comprehensively analyzed in COVID-19 and long COVID patients in analysis.
📄 https://pubmed.ncbi.nlm.nih.gov/41627524/
📄 https://pubmed.ncbi.nlm.nih.gov/41627524/
Income inequalities created healthcare access barriers for long COVID patients despite Austria's universal system. Lower-income patients faced more GP barriers including not being taken seriously, symptom dismissal, and cost burdens in Austrian obs...
📄 https://pubmed.ncbi.nlm.nih.gov/41503716/
📄 https://pubmed.ncbi.nlm.nih.gov/41503716/
February 2, 2026 at 10:52 PM
Income inequalities created healthcare access barriers for long COVID patients despite Austria's universal system. Lower-income patients faced more GP barriers including not being taken seriously, symptom dismissal, and cost burdens in Austrian obs...
📄 https://pubmed.ncbi.nlm.nih.gov/41503716/
📄 https://pubmed.ncbi.nlm.nih.gov/41503716/
Five distinct long COVID phenotypes were linked to specific immune disruptions 6 months post-infection. IL-1 markers showed 3.2x higher odds, IL-17 markers 2.5x higher odds in long COVID patients vs controls in obs study. (n=926)
📄 https://pubmed.ncbi.nlm.nih.gov/41391701/
📄 https://pubmed.ncbi.nlm.nih.gov/41391701/
February 2, 2026 at 8:13 PM
Five distinct long COVID phenotypes were linked to specific immune disruptions 6 months post-infection. IL-1 markers showed 3.2x higher odds, IL-17 markers 2.5x higher odds in long COVID patients vs controls in obs study. (n=926)
📄 https://pubmed.ncbi.nlm.nih.gov/41391701/
📄 https://pubmed.ncbi.nlm.nih.gov/41391701/
Blood vessel repair cells showed altered death patterns in long COVID patients vs controls, with fewer dying cells but uncertain significance in small obs study. (n=21)
📄 https://pubmed.ncbi.nlm.nih.gov/41561147/
📄 https://pubmed.ncbi.nlm.nih.gov/41561147/
February 2, 2026 at 8:08 PM
Blood vessel repair cells showed altered death patterns in long COVID patients vs controls, with fewer dying cells but uncertain significance in small obs study. (n=21)
📄 https://pubmed.ncbi.nlm.nih.gov/41561147/
📄 https://pubmed.ncbi.nlm.nih.gov/41561147/
Anxiety and depression symptoms became more prevalent during early COVID-19 pandemic, while mental health services were compromised by pandemic factors in Lancet commission review.
📄 https://pubmed.ncbi.nlm.nih.gov/41577420/
📄 https://pubmed.ncbi.nlm.nih.gov/41577420/
February 2, 2026 at 3:50 PM
Anxiety and depression symptoms became more prevalent during early COVID-19 pandemic, while mental health services were compromised by pandemic factors in Lancet commission review.
📄 https://pubmed.ncbi.nlm.nih.gov/41577420/
📄 https://pubmed.ncbi.nlm.nih.gov/41577420/
Modified COVID-19 Yorkshire Scale (C19-YRSm) demonstrated good reliability for measuring long COVID symptoms and functional disability, with 81-82% internal consistency across symptom severity and functional subscales in multicenter validation study....
📄 https://pubmed.ncbi.nlm.nih.gov/41586458/
📄 https://pubmed.ncbi.nlm.nih.gov/41586458/
February 2, 2026 at 3:10 PM
Modified COVID-19 Yorkshire Scale (C19-YRSm) demonstrated good reliability for measuring long COVID symptoms and functional disability, with 81-82% internal consistency across symptom severity and functional subscales in multicenter validation study....
📄 https://pubmed.ncbi.nlm.nih.gov/41586458/
📄 https://pubmed.ncbi.nlm.nih.gov/41586458/
Lung diffusion capacity improved from 42% impaired at 6 months to 35% at 36 months post-COVID. Ground-glass opacities decreased from 32% to 20%, but lung fibrosis persisted at 27-47% with no significant change in 3-year syst review. (n=25,766)
📄 https://pubmed.ncbi.nlm.nih.gov/41592552/
📄 https://pubmed.ncbi.nlm.nih.gov/41592552/
February 2, 2026 at 2:29 PM
Lung diffusion capacity improved from 42% impaired at 6 months to 35% at 36 months post-COVID. Ground-glass opacities decreased from 32% to 20%, but lung fibrosis persisted at 27-47% with no significant change in 3-year syst review. (n=25,766)
📄 https://pubmed.ncbi.nlm.nih.gov/41592552/
📄 https://pubmed.ncbi.nlm.nih.gov/41592552/
Brain fluid chambers (choroid plexus) were enlarged in long COVID vs recovered COVID patients and linked to Alzheimer's proteins in blood and cognitive decline in obs study. (n=179)
📄 https://pubmed.ncbi.nlm.nih.gov/41612939/
📄 https://pubmed.ncbi.nlm.nih.gov/41612939/
February 2, 2026 at 1:49 PM
Brain fluid chambers (choroid plexus) were enlarged in long COVID vs recovered COVID patients and linked to Alzheimer's proteins in blood and cognitive decline in obs study. (n=179)
📄 https://pubmed.ncbi.nlm.nih.gov/41612939/
📄 https://pubmed.ncbi.nlm.nih.gov/41612939/
Smell training with or without nerve stimulation will be tested vs placebo in long COVID patients with persistent smell loss in 12-week at-home RCT. (n=180)
📄 https://pubmed.ncbi.nlm.nih.gov/41488386/
📄 https://pubmed.ncbi.nlm.nih.gov/41488386/
February 2, 2026 at 1:09 PM
Smell training with or without nerve stimulation will be tested vs placebo in long COVID patients with persistent smell loss in 12-week at-home RCT. (n=180)
📄 https://pubmed.ncbi.nlm.nih.gov/41488386/
📄 https://pubmed.ncbi.nlm.nih.gov/41488386/
Sweet, umami, and bitter taste loss was linked to damaged PLCβ2 receptor cells in long COVID patients with taste dysfunction 12+ months post-infection. Only 11% had severe overall taste deficits, but 39% lost one or more taste qualities in obs study....
📄 https://pubmed.ncbi.nlm.nih.gov/41610163/
📄 https://pubmed.ncbi.nlm.nih.gov/41610163/
January 31, 2026 at 12:06 AM
Sweet, umami, and bitter taste loss was linked to damaged PLCβ2 receptor cells in long COVID patients with taste dysfunction 12+ months post-infection. Only 11% had severe overall taste deficits, but 39% lost one or more taste qualities in obs study....
📄 https://pubmed.ncbi.nlm.nih.gov/41610163/
📄 https://pubmed.ncbi.nlm.nih.gov/41610163/
Gastrointestinal long COVID symptoms and inflammatory markers were characterized in patients two years after severe SARS-CoV-2 infection in obs study.
📄 https://pubmed.ncbi.nlm.nih.gov/41611926/
📄 https://pubmed.ncbi.nlm.nih.gov/41611926/
January 30, 2026 at 10:05 PM
Gastrointestinal long COVID symptoms and inflammatory markers were characterized in patients two years after severe SARS-CoV-2 infection in obs study.
📄 https://pubmed.ncbi.nlm.nih.gov/41611926/
📄 https://pubmed.ncbi.nlm.nih.gov/41611926/
Ethnic minorities had 18% higher long COVID symptom burden and 19% more symptoms vs Danish patients, with more heart, lung, psychological and gut symptoms, but were less likely to be on sick leave in Danish obs study. (n=864)
📄 https://pubmed.ncbi.nlm.nih.gov/41612118/
📄 https://pubmed.ncbi.nlm.nih.gov/41612118/
January 30, 2026 at 3:06 PM
Ethnic minorities had 18% higher long COVID symptom burden and 19% more symptoms vs Danish patients, with more heart, lung, psychological and gut symptoms, but were less likely to be on sick leave in Danish obs study. (n=864)
📄 https://pubmed.ncbi.nlm.nih.gov/41612118/
📄 https://pubmed.ncbi.nlm.nih.gov/41612118/
Living with others was linked to fewer depressive symptoms vs living alone in long COVID patients. Larger social networks were linked to fewer anxiety symptoms in German obs study. (n=410)
📄 https://pubmed.ncbi.nlm.nih.gov/41605350/
📄 https://pubmed.ncbi.nlm.nih.gov/41605350/
January 29, 2026 at 10:05 PM
Living with others was linked to fewer depressive symptoms vs living alone in long COVID patients. Larger social networks were linked to fewer anxiety symptoms in German obs study. (n=410)
📄 https://pubmed.ncbi.nlm.nih.gov/41605350/
📄 https://pubmed.ncbi.nlm.nih.gov/41605350/
Early monoclonal antibody therapy was linked to 2.2x higher risk of autoimmune diseases like lupus and rheumatoid arthritis vs no treatment, but showed no significant impact on overall long COVID risk in high-risk patients in Singapore obs study....
📄 https://pubmed.ncbi.nlm.nih.gov/41592666/
📄 https://pubmed.ncbi.nlm.nih.gov/41592666/
January 29, 2026 at 3:44 PM
Early monoclonal antibody therapy was linked to 2.2x higher risk of autoimmune diseases like lupus and rheumatoid arthritis vs no treatment, but showed no significant impact on overall long COVID risk in high-risk patients in Singapore obs study....
📄 https://pubmed.ncbi.nlm.nih.gov/41592666/
📄 https://pubmed.ncbi.nlm.nih.gov/41592666/
New-onset diabetes developed in 8.3% of COVID survivors, with type 2 diabetes at 8.9% and type 1 at 0.86% in syst review of 33 studies.
📄 https://pubmed.ncbi.nlm.nih.gov/41605818/
📄 https://pubmed.ncbi.nlm.nih.gov/41605818/
January 29, 2026 at 3:24 PM
New-onset diabetes developed in 8.3% of COVID survivors, with type 2 diabetes at 8.9% and type 1 at 0.86% in syst review of 33 studies.
📄 https://pubmed.ncbi.nlm.nih.gov/41605818/
📄 https://pubmed.ncbi.nlm.nih.gov/41605818/
Pre-existing anxiety and depression was linked to 78% higher long COVID odds vs women with neither condition in US longit. study. (n=18,820)
📄 https://pubmed.ncbi.nlm.nih.gov/41589860/
📄 https://pubmed.ncbi.nlm.nih.gov/41589860/
January 29, 2026 at 2:44 PM
Pre-existing anxiety and depression was linked to 78% higher long COVID odds vs women with neither condition in US longit. study. (n=18,820)
📄 https://pubmed.ncbi.nlm.nih.gov/41589860/
📄 https://pubmed.ncbi.nlm.nih.gov/41589860/
Heart failure, coronary disease, and stroke patients were more susceptible to flu infection, while flu increased risks for heart attack, stroke, and atrial fibrillation in Finnish obs study. (n=319,809)
📄 https://pubmed.ncbi.nlm.nih.gov/41591677/
📄 https://pubmed.ncbi.nlm.nih.gov/41591677/
January 29, 2026 at 2:04 PM
Heart failure, coronary disease, and stroke patients were more susceptible to flu infection, while flu increased risks for heart attack, stroke, and atrial fibrillation in Finnish obs study. (n=319,809)
📄 https://pubmed.ncbi.nlm.nih.gov/41591677/
📄 https://pubmed.ncbi.nlm.nih.gov/41591677/
Long COVID patients had 3 healthcare visits vs 0 for recovered patients in past 3 months. Work absenteeism occurred only in symptomatic group. Cognitive factors didn't explain higher healthcare use in obs study. (n=225)
📄 https://pubmed.ncbi.nlm.nih.gov/41593296/
📄 https://pubmed.ncbi.nlm.nih.gov/41593296/
January 29, 2026 at 1:04 PM
Long COVID patients had 3 healthcare visits vs 0 for recovered patients in past 3 months. Work absenteeism occurred only in symptomatic group. Cognitive factors didn't explain higher healthcare use in obs study. (n=225)
📄 https://pubmed.ncbi.nlm.nih.gov/41593296/
📄 https://pubmed.ncbi.nlm.nih.gov/41593296/
Women with long COVID had higher symptom burden, especially fatigue and brain fog, plus reduced immune cell function vs men who showed elevated inflammatory markers in obs study. (n=60)
📄 https://pubmed.ncbi.nlm.nih.gov/41593681/
📄 https://pubmed.ncbi.nlm.nih.gov/41593681/
January 29, 2026 at 1:03 AM
Women with long COVID had higher symptom burden, especially fatigue and brain fog, plus reduced immune cell function vs men who showed elevated inflammatory markers in obs study. (n=60)
📄 https://pubmed.ncbi.nlm.nih.gov/41593681/
📄 https://pubmed.ncbi.nlm.nih.gov/41593681/
Female sex was linked to all 4 persistent long COVID symptoms (fatigue, dyspnoea, insomnia, confusion) up to 12 months post-discharge. Fatigue was most common. Severe acute COVID predicted symptom improvement over time in Italian cohort. (n=1,666)
📄 https://pubmed.ncbi.nlm.nih.gov/41601165/
📄 https://pubmed.ncbi.nlm.nih.gov/41601165/
January 29, 2026 at 12:03 AM
Female sex was linked to all 4 persistent long COVID symptoms (fatigue, dyspnoea, insomnia, confusion) up to 12 months post-discharge. Fatigue was most common. Severe acute COVID predicted symptom improvement over time in Italian cohort. (n=1,666)
📄 https://pubmed.ncbi.nlm.nih.gov/41601165/
📄 https://pubmed.ncbi.nlm.nih.gov/41601165/
98% of long COVID patients exceeded at least one rehabilitation threshold, with 85% needing multiple types. Most common needs: pulmonary rehab (83%), mental health support (78%), neurorehab (70%) in BC clinic obs study. (n=1,237)
📄 https://pubmed.ncbi.nlm.nih.gov/41603315/
📄 https://pubmed.ncbi.nlm.nih.gov/41603315/
January 28, 2026 at 11:23 PM
98% of long COVID patients exceeded at least one rehabilitation threshold, with 85% needing multiple types. Most common needs: pulmonary rehab (83%), mental health support (78%), neurorehab (70%) in BC clinic obs study. (n=1,237)
📄 https://pubmed.ncbi.nlm.nih.gov/41603315/
📄 https://pubmed.ncbi.nlm.nih.gov/41603315/
A blood test measuring antibody responses to 14 COVID variants identified 3 long COVID immune patterns: hypo-immune, hyperimmune, and normal-range, with 80% diagnostic accuracy using IgG3 levels in obs study. (n=30)
📄 https://www.medrxiv.org/content/10.64898/2026.01.26.26344863v1
📄 https://www.medrxiv.org/content/10.64898/2026.01.26.26344863v1
January 27, 2026 at 11:12 PM
A blood test measuring antibody responses to 14 COVID variants identified 3 long COVID immune patterns: hypo-immune, hyperimmune, and normal-range, with 80% diagnostic accuracy using IgG3 levels in obs study. (n=30)
📄 https://www.medrxiv.org/content/10.64898/2026.01.26.26344863v1
📄 https://www.medrxiv.org/content/10.64898/2026.01.26.26344863v1
January 27, 2026 at 5:09 AM