Can't wait for this!!

This is amazing. 💯 ingenuity

Super grateful to Brad for all the support, to @walkersamuelj.bsky.social for introducing me to the wonderful worlds of systems neuroscience and feeding regulation, to @amdouglass.bsky.social for always pointing me in the right direction, and all the other co-authors for their contributions!

We discovered an excitatory PVH-Sim2→ARC-AgRP circuit whereby the PVH excites ARC-AgRP neurons in response to the unexpected unavailability of food. This genetically specified circuit is essential for normal energy balance and enables the brain to predict and prevent deviations from homeostasis.

ARC-AgRP "hunger" neurons were found, very unexpectedly, to be inhibited by cognitively-processed sensory cues that anticipate ingestion of food. In this work, we asked are ARC-AgRP neurons also regulated by cues that signal the absence of food and thus able to predict future energy deficit?

Really excited to share my co-first publication together with @walkersamuelj.bsky.social from the Lowell lab @bidmcreseach.bsky.social @harvardmed.bsky.social!

Not sure if I've ever read a critical piece, but I've definitely heard it 😅

Not exactly the same but you might try using AAV-TeNT that blocks synaptic vesicle fusion ("silencing" the infected neuron)

The mission of the NIMHD is "to lead scientific research in humans to improve minority health and reduce health disparities in the United States and its territories."

Let me put this as delicately as possible:

Fuck off, you white supremacist asshole

2/2

Heartbreaking and senseless...

RFK Jr. said multiple times during his house and senate hearings today that no scientists have been fired from federal agencies. Our reporting has shown that hundreds, if not thousands, of scientists have been let go from NIH/CDC/FDA

Love this!!

This is not good...

Sometimes I get imposter syndrome but then I remember this guy is in charge of healthcare in the US and feel better

And now all the energy spent to fight for those programs!!

Mouse models of gender affirming hormone therapy can improve outcomes for trans people and for any cis person with hormones or receiving hormone therapies.

What helps is standing in solidarity with us, speaking on the importance of and fighting for the research, not jokes about "transgenic mice" 🧪

Congrats Elisa and Niccolò! Very glad to have contributed to this project in a small way and happy to see the preprint.

Check it out if you're interested in looong projecting spinal neurons and their role in movement! Lots of cool rabies tracing, spinal circuits and skilled locomotor behavior

CTB for traced cells? If so then yes! I can send you my protocol

💯💯💯 couldn't agree more!!

March 7. Stand Up For Science. Rallies in DC and nationwide. 🧪

Please visit the website and spread the word.

www.standupforscience2025.org

A useful tool and a great thing to do...

5calls.org/issue/nih-ns...

Great thread on the fuckery Elon and Donald are wreaking on US science