@lukebsnell.bsky.social
Reposted
We show no improvement in pathogen detection or genome recovery X10 with longer turnaround time and higher failure rates for the dual-arm approach.
February 4, 2026 at 6:39 PM
We show no improvement in pathogen detection or genome recovery X10 with longer turnaround time and higher failure rates for the dual-arm approach.
Reposted
Our latest preprint compares the dual-arm nanopore workflow with the respiratory metagenomics protocol currently implemented across the NHS, using clinical samples.
👉 www.researchsquare.com/article/rs-8...
@nhsmetagenomicsnet.bsky.social @lukebsnell.bsky.social @ronandoyle.bsky.social
👉 www.researchsquare.com/article/rs-8...
@nhsmetagenomicsnet.bsky.social @lukebsnell.bsky.social @ronandoyle.bsky.social
Comparison of nanopore methods for respiratory clinical metagenomics
Respiratory metagenomic sequencing is increasingly used for rapid, pan-microbial diagnosis in clinical practice, but there is a need to evaluate different wet lab protocols for performance and feasibi...
www.researchsquare.com
February 4, 2026 at 6:36 PM
Our latest preprint compares the dual-arm nanopore workflow with the respiratory metagenomics protocol currently implemented across the NHS, using clinical samples.
👉 www.researchsquare.com/article/rs-8...
@nhsmetagenomicsnet.bsky.social @lukebsnell.bsky.social @ronandoyle.bsky.social
👉 www.researchsquare.com/article/rs-8...
@nhsmetagenomicsnet.bsky.social @lukebsnell.bsky.social @ronandoyle.bsky.social
Reposted
This is finally out.
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections
Snell et al. develop sequencing methodology to identify full-length spike haplotypes
and show that persistent SARS-CoV-2 infections drive divergent haplotype emergence,
accelerating viral evolution an...
www.cell.com
February 2, 2026 at 4:09 PM
This is finally out.
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
Reposted
What an inspiring day! Last week we hosted our second Network Day, bringing together over 120 people. We explored the development of the national pilot metagenomic service, which is improving detection & treatment of respiratory infections. Thank you to all who joined and to our fantastic speakers!
November 13, 2025 at 4:53 PM
What an inspiring day! Last week we hosted our second Network Day, bringing together over 120 people. We explored the development of the national pilot metagenomic service, which is improving detection & treatment of respiratory infections. Thank you to all who joined and to our fantastic speakers!
Reposted
Implementing rapid pan-microbial metagenomics in paediatric intensive care https://www.medrxiv.org/content/10.1101/2025.10.07.25337257v1
October 10, 2025 at 9:43 PM
Implementing rapid pan-microbial metagenomics in paediatric intensive care https://www.medrxiv.org/content/10.1101/2025.10.07.25337257v1
Reposted
New research article
Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #OpenAccess #OA
Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #OpenAccess #OA
October 2, 2025 at 8:47 AM
New research article
Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #OpenAccess #OA
Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #OpenAccess #OA