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LUMICKS @lumicks.bsky.social · 6d

Publication link: www.nature.com/articles/s41... - Phase-separated NDF−FACT condensates facilitate transcription elongation on chromatin.

Phase-separated NDF−FACT condensates facilitate transcription elongation on chromatin - Nature Cell Biology

Li, Burgos-Bravo and colleagues report that NDF phase separation regulates FACT condensation, which enhances transcription by generating a localized biochemical environment that promotes nucleosome disassembly while preserving chromatin integrity by retaining histones.

www.nature.com

LUMICKS @lumicks.bsky.social · 6d

Targeting FACT in cancer cells has shown efficacy in preclinical trials, but by which mechanism? Unclear.

Enter: this new study from the Bustamante Lab at UC Berkeley. It reveals that NDF-FACT condensates form on transcribing PolII and enhance nucleosome disassembly and PolII progression.

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LUMICKS @lumicks.bsky.social · 16d

TODAY: Join Dr. Barden for his talk on innovative techniques underlying rational CAR design. Register for a live seat or post-event recording: bit.ly/464vLyZ

Welcome! You are invited to join a webinar: Rational CAR design: integrating affinity and tonic signaling. After registering, you will receive a confirmation email about joining the webinar.

The success of chimeric antigen receptor (CAR) T cell therapy for hematological malignancies has not yet translated into long-term elimination of solid tumors, indicating the need for adequate tuning ...

bit.ly

Reposted by LUMICKS

Daniela Barillà @danielabarilla.bsky.social · 19d

It has been a blast 💥!Awesome atmosphere, networking & knowledge exchange at @biophychrom.bsky.social
Huge thanks 🙏 to all the Participants, Rachel & Kinga from @biochemsoc.bsky.social & the Sponsors @plasmidsaurus.bsky.social @lumicks.bsky.social @emanuellissek.bsky.social @ei-science.bsky.social

Speaker delivering a talk at the meeting.

Scientists at the old Eagle 🦅& Child pub

Gala dinner at the 14th century timber-framed Hospitium in York.

Group photo with St Mary’s Abbey ruins in the background

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LUMICKS @lumicks.bsky.social · 22d

Finding the right CAR affinity is tricky: too low fails, too high impairs function. Measuring cell avidity helps define the productive window, where affinity + avidity drive CAR clustering, persistence & efficacy.

👉 Join Dr. Markus Barden: bit.ly/464vLyZ

LUMICKS @lumicks.bsky.social · 29d

TODAY: Discover how Prof. Taekjip Ha (Harvard University) used the LUMICKS C-Trap to uncover real-time dynamics of chromatin remodelers and transcription factors at the single-molecule level.

Join the webinar: bit.ly/3VdxuNs

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LUMICKS @lumicks.bsky.social · Sep 5

CAR T cell therapy has revolutionized treatment for blood cancers, but why does it still not work on solid tumors?

Register for this upcoming webinar by Markus Barden (postdoc from Hinrich Abken's lab, Leibniz Institute for Immunotherapy) to learn more: bit.ly/464vLyZ

LUMICKS @lumicks.bsky.social · Sep 2

Looking back at a fantastic SMBio 2025 China at Hefei this past week 💪! Thank you USTC and Guoqiang Bi & Sai Li for hosting and co-organizing this memorable event for the single-molecule community.

Group photo of the attendees of the SMBio 2025 China symposium in Hefei.

LUMICKS @lumicks.bsky.social · Aug 25

👌 How to visualize dynamic protein-DNA interactions in real time, including co-localization and diffusion, to uncover critical molecular mechanisms.

Created in collaboration with Prof. Bennett van Houten @benvh123.bsky.social ‬

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LUMICKS @lumicks.bsky.social · Aug 25

✌ How to leverage standard mammalian cell culture techniques to perform sophisticated single-molecule experiments, eliminating the need for extensive biochemistry expertise.

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LUMICKS @lumicks.bsky.social · Aug 25

What you'll learn:

👉 How to observe DNA-binding proteins in their natural state, complete with post-translational modifications, revealing insights inaccessible through purified protein assays.

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LUMICKS @lumicks.bsky.social · Aug 25

This guide can empower you to bridge the gap between cellular biology and single-molecule biophysics 👇.

Read: "Accelerating DNA-Protein Interaction Experiments with Nuclear Extracts in the C-Trap". Created in collaboration with Prof. Bennett Van Houten (University of Pittsburgh).

bit.ly/4fPnHXk

Accelerating DNA-protein interaction experiments with nuclear extracts in the C-Trap - Application Note - LUMICKS

Category: DNA-Binding proteins | Access our application note titled 'Accelerating DNA-protein interaction experiments with nuclear extracts in the C-Trap' .

www.lumicks.com

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LUMICKS @lumicks.bsky.social · Aug 21

Congrats on your new C-Trap system! We’re excited to support your journey in single-molecule research and are fully committed to helping you make scientific breakthroughs!

Umeå Plant Science Centre @umeaplantsciencecentre.se · Aug 20

🧪🧬NEWS - Research facility allows to monitor molecules in motion

At the new C-Trap Facility, scientist can now manipulate and observe dynamic molecular processes in real time.🔬

Curious to learn more? Take a look here👇:
www.upsc.se/about-upsc/n...

📸 Mattias Pettersson @umeauniversitet.bsky.social

A short-haired men in a white labcoat is pipetting something into a large, black machine. Photo credit: Mattias Pettersson, Umeå University

Three computer screens are displayed and before is a hand controlling a joystick. Photo credit: Mattias Pettersson, Umeå University

A hand is holding a black device that is connected to small transparent pipes. Photo credit: Mattias Pettersson, Umeå University

A women and a men in white labcoats are sitting in front of a computer screen and discuss. The women is shown on something on the screen. Photo credit: Mattias Pettersson, Umeå University

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LUMICKS @lumicks.bsky.social · Aug 20

About 2 months ago, our product managers Bas Groen and Adalberto Costessi introduced the latest upgrades for the C-Trap.

Catch the intro from LUMICKS product managers on how to make your C-Trap faster, easier, and more reproducible. Watch now: www.lumicks.com/webinars/c-t...

Watch: C-Trap Accelerator Suite - LUMICKS

Speaker: LUMICKS, . In this webinar, we discuss C-Trap Accelerator Suite. Category:

www.lumicks.com

LUMICKS @lumicks.bsky.social · Aug 14

Discuss single-molecule science with world-renowned Prof.
𝗧𝗮𝗲𝗸𝗷𝗶𝗽 𝗛𝗮 (Harvard)! Join the upcoming 𝗡𝗮𝘁𝘂𝗿𝗲 𝘄𝗲𝗯𝗶𝗻𝗮𝗿 to learn how dynamic single-molecule tools reveal new mechanisms behind nucleosome mobilization and transcriptional control!

Registrations are now open: