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Reposted by Lydia Finley

KatajistoLab @katajistolab.bsky.social · 8d

Check out the symposium organized by our CoE, excited to have Marcia Haigis, @lydiafinley.bsky.social, Matthias Hebrok and Tom MacVicar over in Helsinki in November. Sign up by October 22nd 👇

MetaStem @metastem.bsky.social · 8d

Excited to announce our Stem Cell Metabolism Symposium organized in Helsinki on November 12th. Fantastic invited speakers Marcia Haigis, Lydia Finley, Matthias Hebrok and Tom MacVicar. Sign up by Oct 22nd, free of charge, welcome! @hilife-helsinki.bsky.social @helsinki.fi @stemmprogram.bsky.social

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Reposted by Lydia Finley

Michael Glickman @michaelglickman.bsky.social · Jul 28

Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...

Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense

M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...

www.biorxiv.org

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Reposted by Lydia Finley

Muir Lab @muirlab.bsky.social · Jul 19

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social
jci.org/articles/vie... 1/6

JCI - What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment

jci.org

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Reposted by Lydia Finley

KatajistoLab @katajistolab.bsky.social · Jul 14

Proudly presenting Simon’s @simonsterson.bsky.social‬ paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism

Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

www.nature.com

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Reposted by Lydia Finley

Yasemin Sancak @yasesancak.bsky.social · May 31

Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...

Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma

Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.

www.science.org

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Reposted by Lydia Finley

Nature Metabolism @natmetabolism.nature.com · May 5

ICYMI:

Intracellular metabolic gradients dictate dependence on exogenous pyruvate

Nature Metabolism, Published online: 28 April 2025; doi:10.1038/s42255-025-01289-8Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a key metabolite in central carbon metabolism.

bit.ly

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Lydia Finley @lydiafinley.bsky.social · Apr 29

Thank you Christian!

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Reposted by Lydia Finley

Ben Jackson @btjackson.bsky.social · Apr 28

I'm excited to share our latest story from the
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Intracellular metabolic gradients dictate dependence on exogenous pyruvate

Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...

rdcu.be

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Reposted by Lydia Finley

KatajistoLab @katajistolab.bsky.social · Apr 28

Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9

Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications

Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...

www.nature.com

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Reposted by Lydia Finley

Keystone Symposia @keystonesymposia.bsky.social · Apr 10

Showcase your research! Submit your poster abstract by April 16 (11:59pm MST) to join speakers @lydiafinley.bsky.social, Ralph J. DeBeradinis, & Keynote Navdeep Chandel. Apply now: keysym.us/KSMetabDev25. Can't attend? Access insights On Demand for 6 months post-conference!

#KSMetabDev25 #cellfate

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Lydia Finley @lydiafinley.bsky.social · Mar 25

2 weeks to go to the annual NYAS cancer metabolism symposium, April 8 at NYU Langone!

www.nyas.org/shaping-scie...

Register now using code CancerMetabolism10 for a 10% discount. And hurry! Last year we sold out!

cc: @lyssiotislab.bsky.social @marcusgon.bsky.social

Cancer Metabolism and Signaling in the Tumor Microenvironment - NYAS

April 8, 2025 | 9:00 AM – 5:00 PM ET Join leading experts at the forefront of cancer metabolism research for a one-day event on April 8, 2025, in New York City. The New York Academy of Sciences invite...

www.nyas.org

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Reposted by Lydia Finley

DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · Mar 21

www.quantamagazine.org/how-metaboli...
Seems like a good time to remind you of an upcoming meeting on this exact topic:
www.keystonesymposia.org/conferences/...

How Metabolism Can Shape Cells’ Destinies | Quanta Magazine

A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life.

www.quantamagazine.org

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Reposted by Lydia Finley

Lyssiotis Lab @lyssiotislab.bsky.social · Mar 20

We are 2 weeks out from the @NYASciences Cancer Metabolism meeting - still time to register! Join us for:

Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)

Please circulate 🔁

events.nyas.org/event/16a78a...

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Reposted by Lydia Finley

Keystone Symposia @keystonesymposia.bsky.social · Mar 19

Unlock $200 in savings on Metabolic and Nutritional Control by registering before 11:59 PM MST on March 20! Don't miss the chance to hear from @lydiafinley.bsky.social this May in Beverly, MA, USA. Secure your spot now: keysym.us/KSMetabDev25.

#KSMetabDev25 #metabolism youtu.be/le7D7qpo4sM

KSQA: Dr. Lydia Finley (Metabolic and Nutritional Control)

YouTube video by KeystoneSymposia

youtu.be

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Reposted by Lydia Finley

DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · Mar 15

1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social
www.science.org/doi/10.1126/...

Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair

Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.

www.science.org

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Reposted by Lydia Finley

Dow Lab @dowlab.bsky.social · Mar 12

New preprint time!!

This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.

www.biorxiv.org/content/10.1...

A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression

Hyperactive WNT signaling is a potent cancer driver, but clinical translation of WNT inhibitors has been hampered on-target toxicities. WNT signaling can be constrained through inhibition of the PARP ...

www.biorxiv.org

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Reposted by Lydia Finley

Keystone Symposia @keystonesymposia.bsky.social · Mar 12

Metabolic & Nutritional Control of Development and Cell Fate is just around the corner. Register by March 20 (11:59pm MST) and snag a $200 discount! Don't miss our incredible speaker lineup! 👉 keysym.us/KSMetabDev25.

#KSMetabDev25 youtu.be/CSto4rJv40I
@lydiafinley.bsky.social @rjdlab.bsky.social

Metabolic and Nutritional Control Meeting Promo

YouTube video by KeystoneSymposia

youtu.be

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Lydia Finley @lydiafinley.bsky.social · Mar 7

Congratulations @hitelabmskcc.bsky.social and @dirkremus.bsky.social et al!

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Reposted by Lydia Finley

Isaac Harris @harrislab.bsky.social · Feb 28

📢3 weeks left to submit your abstract for the Cancer Metabolism Showcase and Workshop!📢

We already have over 150 registrants!

Sign up for free today at www.cancermetabolismshowcase.org

9:30 AM - 3 PM EST, May 5th and 6th, 2025

www.cancermetabolismshowcase.org

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Reposted by Lydia Finley

Lucas Sullivan @lucasbsullivan.bsky.social · Feb 20

Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:

A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.

bioRxivpreprint @biorxivpreprint.bsky.social · Feb 17

Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation https://www.biorxiv.org/content/10.1101/2025.02.12.637975v1

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Lydia Finley @lydiafinley.bsky.social · Feb 14

I am so very sorry for your loss, and thank you for the kind words. My great hope is that our collective actions can improve the life and health of children to come. I know we are working our best on this front.

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Reposted by Lydia Finley

Mara Sherman @marasherman.bsky.social · Feb 7

Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏽💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Now at Cancer Discovery aacrjournals.org/cancerdiscov...

Stromal KITL/SCF maintains pancreas tissue homeostasis and restrains tumor progression

Abstract. Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features of solid tumorigenesis, wherein alterations to...

aacrjournals.org

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Reposted by Lydia Finley

Lyssiotis Lab @lyssiotislab.bsky.social · Feb 5

We are soliciting poster and short talk abstracts for the NYASciences Cancer Metabolism meeting. Just around the corner - join us for awesome metabolism in the Big Apple 🍎

Speakers: Kivanc Birsoy, Christine Chio, Marcia Haigis, Andy Intlekofer, Thales PapaG, Jared Rutter, Dan Wahl, Eileen White

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Lydia Finley @lydiafinley.bsky.social · Feb 4

Why does this matter? Ubiquinone (the OG) loves to deposit electrons on oxygen; rhodoquinone (newbie) is happy to give them to fumarate. Opens up many possibilities for unappreciated redox circuits in our cells. Also, just a great read. Congrats to the Spinelli lab (not on BlueSky?)

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Lydia Finley @lydiafinley.bsky.social · Feb 4

Massive work from Jess Spinelli's lab at UMASS demonstrating a SECOND electron carrier in the mammalian ETC:

www.cell.com/cell/fulltex...

Rhodoquinone carries electrons in the mammalian electron transport chain

Valeros et al. identify rhodoquinone (RQ), an electron carrier present in mammalian mitochondria, that can deliver electrons to fumarate instead of O2 as the terminal electron acceptor. The authors de...

www.cell.com

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