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Reposted by Michael Williamson

Paul Frankland @franklandlab.bsky.social · 8d

New paper from the lab led by Ali Golbabaei. If you’re interested in systems consolidation, generalization and hippocampal neurogenesis a short 🧵 follows:

authors.elsevier.com/a/1lsO73QW8S...

authors.elsevier.com

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Michael Williamson @m-r-williamson.bsky.social · Jul 22

We have a new review out in TINS!

A functional perspective on astrocyte heterogeneity

www.cell.com/trends/neuro...

A functional perspective on astrocyte heterogeneity

Astrocytes are glial cells of the central nervous system (CNS) that perform an array of diverse functions that are essential for brain activity. Studies on the functional diversity of astrocytes sugge...

www.cell.com

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Reposted by Michael Williamson

Baptiste Lacoste @blacoste.bsky.social · Jul 20

Super interesting review on astrocyte development by @m-r-williamson.bsky.social and colleagues ! #astrocytes #glia #review

Development and diversity of astrocytes

Summary: This Development at a Glance article provides an overview of astrocyte ontogeny and morphogenesis, highlighting mechanisms that regulate the development of astrocytes, the most abundant glial...

doi.org

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Reposted by Michael Williamson

Lewis Holt @lewisholt.bsky.social · Jul 11

Absolutely thrilled to share the first half of my PhD work! Super proud to see it finally out!
www.nature.com/articles/s41...

Thread below for a quick (10 point) recap of what we found!
🧵🧪🧠

A divergent astrocytic response to stress alters activity patterns via distinct mechanisms in male and female mice - Nature Communications

Early-life stress has lifelong impacts on neuronal function and behavior. Here, the authors show that astrocytic glucocorticoid receptor signaling drives stress-induced neuronal and behavioral change ...

www.nature.com

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Michael Williamson @m-r-williamson.bsky.social · Jul 8

Sharing our new short review on development and diversity of astrocytes!

journals.biologists.com/dev/article-...

Development and diversity of astrocytes

Summary: This Development at a Glance article provides an overview of astrocyte ontogeny and morphogenesis, highlighting mechanisms that regulate the development of astrocytes, the most abundant glial...

journals.biologists.com

1

Reposted by Michael Williamson

Craig Brown @craigedbrown.bsky.social · May 27

Happy to share new paper from MSc grads Myrthe and Jenna. We asked the question, when part of the brain dies during stroke, what happens to local and distant cortical neurons that innervate the stroke site (in S1 cortex) or those that receive outputs? journals.sagepub.com/doi/10.1177/...

Retrograde and anterograde trans-synaptic viral tracing of neuronal connections reveals local and distant effects of ischemic stroke on dendritic spines - Myrthe Van Sprengel, Jenna Butterworth, Patri...

Focal stroke leads to complex neurological disturbances with variable recovery. One explanation for this variability is that stroke disrupts local and remote ne...

journals.sagepub.com

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Reposted by Michael Williamson

Papouin Lab @ WashU @papouinlab.bsky.social · May 16

Thought this would be a nice way to enter the bsky community👇Delighted for Katie (now in Chris Dulla's lab at Tufts). Thank you to our collaborators, to the reviewers and to Cagla Eroglu for the highlight!
www.science.org/doi/10.1126/...

Norepinephrine signals through astrocytes to modulate synapses

Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...

www.science.org

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Reposted by Michael Williamson

Paul Frankland @franklandlab.bsky.social · May 14

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

1/n

Systems consolidation reorganizes hippocampal engram circuitry

Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

rdcu.be

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Reposted by Michael Williamson

Amy Gleichman @amygleichman.bsky.social · May 1

Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out!
gleichmanlab.com

The Gleichman lab

gleichmanlab.com

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Michael Williamson @m-r-williamson.bsky.social · May 1

Congrats Amy!!

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Reposted by Michael Williamson

Annabelle Singer @drannabellesinger.bsky.social · Apr 9

Check out our latest paper today in Nature: “Goal specific hippocampal inhibition gates learning” www.nature.com/articles/s41...
By Nuri Jeong, Xiao Zheng, Abby Paulson, Steph Prince and colleagues.

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Michael Williamson @m-r-williamson.bsky.social · Jan 17

I can also vouch for this one. Works great.

Reposted by Michael Williamson

Debo (Debosmita Sardar) @debo-astrocyte.bsky.social · Dec 26

I get a lot of questions on the #NIH #K99 #postdoc to faculty transition award. Decided to pen my thoughts and experiences towards receiving the K99/R00 - hoping it would be helpful for the community.

Please find article link at -
debosardarlab.org/blog

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Michael Williamson @m-r-williamson.bsky.social · Dec 24

Thanks so much for this nice preview 😊

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Reposted by Michael Williamson

Sofiya Zbaranska 🇺🇦 @neur1s.bsky.social · Dec 23

⭐Christmas highlight in Cell Research! @sjo09.bsky.social and I address the idea that learning-associated astrocytes become essential members of a memory engram ensemble, shifting the neuron-centric view of memory function. Big shoutout to @m-r-williamson.bsky.social!

www.nature.com/articles/s41...

Astrocytes: emerging stars of engrams - Cell Research

Cell Research - Astrocytes: emerging stars of engrams

doi.org

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Reposted by Michael Williamson

Gisella Vetere @gisellavetere.bsky.social · Dec 13

Do you think you’ve conquered the enigma of the memory engram? News flash: You’re only scratching the surface. :)
In our latest work (led by @Clement), we dissected the engram to uncover what information is processed during encoding and becomes the essence of the recalled memory.

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Michael Williamson @m-r-williamson.bsky.social · Dec 11

Congratulations!!

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Michael Williamson @m-r-williamson.bsky.social · Dec 4

🙋🏻‍♂️

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Reposted by Michael Williamson

Michael Williamson @m-r-williamson.bsky.social · Nov 17

For my first post here: excited to share our new work out in Nature!

Learning-associated astrocyte ensembles regulate memory recall

www.nature.com/articles/s41...

Learning-associated astrocyte ensembles regulate memory recall - Nature

A study in mice shows that learning induces c-Fos expression in a subset of astrocytes in the hippocampus, and that ensembles of these learning-associated astrocytes are involved in the recall of memo...

www.nature.com

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Michael Williamson @m-r-williamson.bsky.social · Dec 1

Thanks for this! Could you please add me?

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Reposted by Michael Williamson

Craig Brown @craigedbrown.bsky.social · Nov 28

Congrats to the team! Here we directly image and quantify cerebral #angiogenesis and pruning in vivo. Found interesting regional differences and dependence on #notch signalling. Where you look does matter!

www.cell.com/cell-reports...

Angiogenesis in the mature mouse cortex is governed in a regional- and Notch1-dependent manner

The angiogenic capacity of the mature healthy brain and its underlying mechanisms are unclear. Raudales et al. show that rates of cerebral angiogenesis follow regional gradients and are regulated by e...

www.cell.com

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Michael Williamson @m-r-williamson.bsky.social · Nov 21

Thanks! Could you please add me?

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Michael Williamson @m-r-williamson.bsky.social · Nov 18

Fair enough 😂

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Michael Williamson @m-r-williamson.bsky.social · Nov 18

It’s all downhill from here

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Michael Williamson @m-r-williamson.bsky.social · Nov 18

Thanks for this! Could you please add me?