Baptiste Lacoste
@blacoste.bsky.social
Senior Scientist, Associate Professor & Program Director @ OHRI & uOttawa 🇨🇦. Fascinated by vascular & metabolic causes of neurodevelopmental disorders, SciArt and the night sky 🔬 🎨 🔭 Follow for 🧪 news and more! Look for #cerebrovascular
PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development
PDGFRα is required for postnatal cerebral perivascular fibroblast development
Perivascular fibroblasts (PVFs) are a cell type associated with large diameter blood vessels in the brain and spinal cord parenchyma and leptomeninges…
www.sciencedirect.com
November 20, 2025 at 3:30 AM
PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development
Reposted by Baptiste Lacoste
Excited to share the latest from our lab (final version, open access):
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
November 19, 2025 at 1:38 PM
Excited to share the latest from our lab (final version, open access):
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
Brain Capillary Ion Channels: Physiology and Channelopathies
Physiology | @apspublications.bsky.social
journals.physiology.org/doi/full/10....
@uvmlarnermed.bsky.social
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution @cp-neuron.bsky.social #cerebrovascular #hypertension
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution
Hypertension is a leading cause of cognitive impairment, attributed to cerebrovascular insufficiency, blood-brain barrier disruption, and white matter…
www.sciencedirect.com
November 18, 2025 at 2:51 PM
Hypertension-induced neurovascular and cognitive dysfunction at single-cell resolution @cp-neuron.bsky.social #cerebrovascular #hypertension
Excellent new review on the blood-brain barrier, by Alon Friedman and colleague @natureportfolio.nature.com #Cerebrovascular #BloodBrainBarrier
Dynamic modulation of the blood–brain barrier in the healthy brain - Nature Reviews Neuroscience
The blood–brain barrier was conventionally seen as a static protective structure, but a more complex, dynamic view of this barrier has now emerged. In this Review, Friedman et al. discuss the dynamic ...
www.nature.com
November 16, 2025 at 3:48 PM
Excellent new review on the blood-brain barrier, by Alon Friedman and colleague @natureportfolio.nature.com #Cerebrovascular #BloodBrainBarrier
The brain neurovascular epigenome and its association with dementia. #cerebrovascular #epigenetics
The brain neurovascular epigenome and its association with dementia
Ziegler et al. reveal distinct genetic and epigenetic mechanisms underlying Alzheimer’s
disease and cerebral small vessel disease within neurovascular cells, identifying
immune-related AD risk and bro...
www.cell.com
November 12, 2025 at 10:42 AM
The brain neurovascular epigenome and its association with dementia. #cerebrovascular #epigenetics
So happy I have been able to witness the incredible growth and success of (now Dr.) Sozerko Yiandiev, who defended his PhD thesis with brio in Lyon this week! It was a true pleasure to co-mentor Sozerko with @jcourchet.bsky.social during the past 5 years 🍻👨🎓 #Thesis #BrainMetabolism
November 8, 2025 at 6:45 PM
So happy I have been able to witness the incredible growth and success of (now Dr.) Sozerko Yiandiev, who defended his PhD thesis with brio in Lyon this week! It was a true pleasure to co-mentor Sozerko with @jcourchet.bsky.social during the past 5 years 🍻👨🎓 #Thesis #BrainMetabolism
When the stars of glial scar borders and stroke recovery “have a baby”, it gives this 😅 #astrocytes #stroke #cerebrovascular
Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling
Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue…
www.sciencedirect.com
November 8, 2025 at 7:39 AM
When the stars of glial scar borders and stroke recovery “have a baby”, it gives this 😅 #astrocytes #stroke #cerebrovascular
October 20, 2025 at 1:59 AM
Reposted by Baptiste Lacoste
A privilege to chair symposium ‘Vascular function and cognitive health across the lifespan’ symposium today at @ecnp.eu
Thanks to speakers @vcoelhosantoslab.bsky.social Amanda Kiliaan, @mariangelesmoro.bsky.social and @blacoste.bsky.social for their fantastic presentations.
#ECNP2025
Thanks to speakers @vcoelhosantoslab.bsky.social Amanda Kiliaan, @mariangelesmoro.bsky.social and @blacoste.bsky.social for their fantastic presentations.
#ECNP2025
October 14, 2025 at 11:43 AM
A privilege to chair symposium ‘Vascular function and cognitive health across the lifespan’ symposium today at @ecnp.eu
Thanks to speakers @vcoelhosantoslab.bsky.social Amanda Kiliaan, @mariangelesmoro.bsky.social and @blacoste.bsky.social for their fantastic presentations.
#ECNP2025
Thanks to speakers @vcoelhosantoslab.bsky.social Amanda Kiliaan, @mariangelesmoro.bsky.social and @blacoste.bsky.social for their fantastic presentations.
#ECNP2025
An important advance in vascular biology!! #endothelium #vascular
Soluble guanylyl cyclase, the NO receptor, drives vasorelaxation via endothelial S-nitrosation | PNAS
We previously demonstrated that the NO-stimulated soluble guanylyl cyclase (GC1),
which produces cGMP, also has the ability to transfer S-nitrosoth...
www.pnas.org
October 6, 2025 at 9:08 PM
An important advance in vascular biology!! #endothelium #vascular
Thanks again Yao Yao for the kind invite to USF! Super fun visit, I learned a lot from you and your colleagues 🙏🙏
October 6, 2025 at 12:26 PM
Thanks again Yao Yao for the kind invite to USF! Super fun visit, I learned a lot from you and your colleagues 🙏🙏
Interested in assessing #BBB integrity at high resolution in 3D by electron tomography without spending $$$$$ on cryo-EM? I think we can help with this detailed method 😇 #cerebrovascular #microscopy #EM
Volumetric Analysis of the Blood–Brain Barrier After Ischemic Stroke by Electron Tomography in Mice
Objective Transmission electron microscopy (TEM) enables ultrastructural investigation of both organic and nonorganic samples. However, conventional TEM is limited by the acquisition of two-dimensio...
onlinelibrary.wiley.com
September 28, 2025 at 1:48 PM
Interested in assessing #BBB integrity at high resolution in 3D by electron tomography without spending $$$$$ on cryo-EM? I think we can help with this detailed method 😇 #cerebrovascular #microscopy #EM
Very cool new paper from @caglaeroglu.bsky.social's lab showing the mitochondria dynamics regulate astroglial morphogenesis! doi.org/10.1083/jcb.... #Astrocytes #Development
Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex | Journal of Cell Biology | Rockefeller University Press
During cortical astrocyte morphogenesis, mitochondria fragment and decrease in size to populate distal astrocyte processes. Drp1-mediated mitochondrial fis
doi.org
September 12, 2025 at 6:27 PM
Very cool new paper from @caglaeroglu.bsky.social's lab showing the mitochondria dynamics regulate astroglial morphogenesis! doi.org/10.1083/jcb.... #Astrocytes #Development
New work establishing a key role for FOXQ1 in the regulation of brain endothelial metabolism. #Cerebrovascular
FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology
FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This stud...
doi.org
September 7, 2025 at 7:51 PM
New work establishing a key role for FOXQ1 in the regulation of brain endothelial metabolism. #Cerebrovascular
New paper by Philippe Monnier's team: Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke @natureportfolio.nature.com #Stroke #BBB #cerebrovascular
Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke - Nature Cardiovascular Research
Shabanzadeh et al. identify and validate a pathway whereby RGMa cleavage by SKI-1 modifies gene expression related to blood–brain barrier (BBB) integrity after stroke. SKI-1 inhibition restores BBB in...
www.nature.com
August 28, 2025 at 6:31 PM
New paper by Philippe Monnier's team: Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke @natureportfolio.nature.com #Stroke #BBB #cerebrovascular
Absolutely fascinating science and interactions with families here at the 2025 Synchrony Symposium on #autism in Monterey! A wonderful gathering organized by the Brain Foundation. #TranslationalScience
August 23, 2025 at 5:59 PM
Absolutely fascinating science and interactions with families here at the 2025 Synchrony Symposium on #autism in Monterey! A wonderful gathering organized by the Brain Foundation. #TranslationalScience
Thrilled to be listed as invited speaker for @harvardmed.bsky.social's Neurobiology seminar series in December! Please come if you are around 😊. I'll share the whole neurovascular story about neurodevelopmental disorders #ASD #cerebrovascular #seminar
August 19, 2025 at 1:23 PM
Thrilled to be listed as invited speaker for @harvardmed.bsky.social's Neurobiology seminar series in December! Please come if you are around 😊. I'll share the whole neurovascular story about neurodevelopmental disorders #ASD #cerebrovascular #seminar
Anyone here interested in #metabolism in #devbio ?
We recently published a Review article by Jin Zhang & co discussing the relationship between metabolism and #embryogenesis. Enjoy the read! :D
👉https://rdcu.be/eADIT
www.nature.com/articles/s41...
We recently published a Review article by Jin Zhang & co discussing the relationship between metabolism and #embryogenesis. Enjoy the read! :D
👉https://rdcu.be/eADIT
www.nature.com/articles/s41...
Metabolic regulation of key developmental events during mammalian embryogenesis - Nature Cell Biology
This Review discusses the intricate relationship between metabolism and embryogenesis, highlighting the orchestration of key developmental processes by metabolites and signalling molecules that provid...
www.nature.com
August 14, 2025 at 12:23 PM
Another beautiful study by the lab of @andyshihlab.bsky.social published today in @natureportfolio.nature.com 👏🏻👏🏻👏🏻 #cerebrovascular #aging
Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience
How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...
doi.org
August 12, 2025 at 9:12 PM
Another beautiful study by the lab of @andyshihlab.bsky.social published today in @natureportfolio.nature.com 👏🏻👏🏻👏🏻 #cerebrovascular #aging
Really cool stuff on #pericytes @natureportfolio.nature.com !
Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy - Nature Biomedical Engineering
An optimized pipeline for functional ultrasound localization microscopy is safely and non-invasively applied to detect and characterize early microvascular alterations with high spatial and temporal r...
www.nature.com
August 11, 2025 at 9:55 PM
Really cool stuff on #pericytes @natureportfolio.nature.com !
It’s been a long while since I posted an #astrophotography image, but from my vacation in France I have access to clear and deep skies! Below is the heart of M16, and its famous “Pillars of Creation”.🤩
August 1, 2025 at 1:56 PM
It’s been a long while since I posted an #astrophotography image, but from my vacation in France I have access to clear and deep skies! Below is the heart of M16, and its famous “Pillars of Creation”.🤩