Majmundar Laboratory
@majmundarlab.bsky.social
Kidney Genetics Laboratory
@bostonchildrens.bsky.social @harvardmed.bsky.social
majmundarlab.com
Driven to discover, model and treat genetic kidney diseases.
@bostonchildrens.bsky.social @harvardmed.bsky.social
majmundarlab.com
Driven to discover, model and treat genetic kidney diseases.
Sharing a exciting study by Howard Trachtman and colleagues in Lancet demonstrating efficacy of a targeted therapy for genetic FSGS. Exciting development and blueprint for tackling other genetic kidney diseases.
thelancet.com/journals/lancet/article/PIIS0140-6736(25)02255-X/abstract?rss=yes
thelancet.com/journals/lancet/article/PIIS0140-6736(25)02255-X/abstract?rss=yes
TRPC6 inhibition for the treatment of focal segmental glomerulosclerosis: a randomised, placebo-controlled, phase 2 trial of BI 764198
BI 764198 lowered proteinuria and was well tolerated by participants in this trial.
This is the first evidence of efficacy with a podocyte-targeted therapy in FSGS. Larger
randomised controlled trials...
www.thelancet.com
January 31, 2026 at 8:05 PM
Sharing a exciting study by Howard Trachtman and colleagues in Lancet demonstrating efficacy of a targeted therapy for genetic FSGS. Exciting development and blueprint for tackling other genetic kidney diseases.
thelancet.com/journals/lancet/article/PIIS0140-6736(25)02255-X/abstract?rss=yes
thelancet.com/journals/lancet/article/PIIS0140-6736(25)02255-X/abstract?rss=yes
Reposted by Majmundar Laboratory
Predicting better lipids: In a cover-winning @natbiotech.nature.com paper, the Anderson & Langer Labs screened 1.6M lipids in silico to speed up successful designs for mRNA delivery to lungs. www.nature.com/articles/s41...
December 12, 2025 at 5:15 PM
Predicting better lipids: In a cover-winning @natbiotech.nature.com paper, the Anderson & Langer Labs screened 1.6M lipids in silico to speed up successful designs for mRNA delivery to lungs. www.nature.com/articles/s41...
Genes regulate kidney stones. In our recent editorial, Ken Saida and I review the evolving landscape of Mendelian genetics in KSD and discuss findings from a large cohort analysis in cJASN:
doi.org/10.2215/CJN....
@harvardmed.bsky.social @bostonchildrens.bsky.social
doi.org/10.2215/CJN....
@harvardmed.bsky.social @bostonchildrens.bsky.social
doi.org
December 11, 2025 at 3:30 PM
Genes regulate kidney stones. In our recent editorial, Ken Saida and I review the evolving landscape of Mendelian genetics in KSD and discuss findings from a large cohort analysis in cJASN:
doi.org/10.2215/CJN....
@harvardmed.bsky.social @bostonchildrens.bsky.social
doi.org/10.2215/CJN....
@harvardmed.bsky.social @bostonchildrens.bsky.social
In our new @natcomms.nature.com study, we show that intergenic splicing of the NS disease gene/actin regulator NOS1AP is essential for kidney filter function via transcriptomic, proteomic, human genetic & mouse model studies.
@harvardmed.bsky.social @bostonchildrens.bsky.social
t.co/2xegr1OUlm
@harvardmed.bsky.social @bostonchildrens.bsky.social
t.co/2xegr1OUlm
https://www.nature.com/articles/s41467-025-65663-6
t.co
December 11, 2025 at 3:20 PM
In our new @natcomms.nature.com study, we show that intergenic splicing of the NS disease gene/actin regulator NOS1AP is essential for kidney filter function via transcriptomic, proteomic, human genetic & mouse model studies.
@harvardmed.bsky.social @bostonchildrens.bsky.social
t.co/2xegr1OUlm
@harvardmed.bsky.social @bostonchildrens.bsky.social
t.co/2xegr1OUlm