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Reposted by Marc Aurel Busche

UK Dementia Research Institute @ukdri.ac.uk · Aug 1

It was a pleasure to host @marcaurelbusche.bsky.social for a special UK DRI webinar last week on how circuits fail in Alzheimer's disease, and hear about his lab's recent incredible findings 🧠

If you missed it, catch up here 👇
youtu.be/JzPFyO4ef-I?...

Rethinking neurodegeneration: How do brain circuits fail in early Alzheimer's disease?

YouTube video by UK Dementia Research Institute - UK DRI

youtu.be

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Reposted by Marc Aurel Busche

UK Dementia Research Institute @ukdri.ac.uk · Jul 9

🧠 How do brain circuits fail in early Alzheimer's disease? 🧠

Join @marcaurelbusche.bsky.social for the next research webinar in our 'Rethinking neurodegeneration' series, taking place 4-5pm (BST), Thurs 24 July 🗓️

🚨 Register for free today! 🚨 Full info 👉 www.ukdri.ac.uk/events/rethi...

How do brain circuits fail in early Alzheimer's disease? With Dr Marc Aurel Busche

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Marc Aurel Busche @marcaurelbusche.bsky.social · Jul 11

I‘m excited to speak at this UK DRI webinar “Rethinking Neurodegeneration” on 24 July, discussing cell type- and circuit-specific vulnerability in early Alzheimer’s. #Alzheimers #Neurodegeneration #UKDRI

UK Dementia Research Institute @ukdri.ac.uk · Jul 9

🧠 How do brain circuits fail in early Alzheimer's disease? 🧠

Join @marcaurelbusche.bsky.social for the next research webinar in our 'Rethinking neurodegeneration' series, taking place 4-5pm (BST), Thurs 24 July 🗓️

🚨 Register for free today! 🚨 Full info 👉 www.ukdri.ac.uk/events/rethi...

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Reposted by Marc Aurel Busche

UCL Faculty of Brain Sciences @uclbrainscience.bsky.social · Jul 2

Research led by @marcaurelbusche.bsky.social and Dr Samuel Harris (@uclqsion.bsky.social & @ukdri.ac.uk) has discovered that the amyloid precursor protein (APP) family is essential for healthy communication between brain cells.

Alzheimer’s-linked proteins help to maintain healthy communication in the brain

Researchers at UCL Queen Square Institute of Neurology have discovered that the amyloid precursor protein (APP) family is essential for healthy communication between brain cells.

buff.ly

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Reposted by Marc Aurel Busche

UK Dementia Research Institute @ukdri.ac.uk · Jun 27

Research led by Dr Samuel Harris and @marcaurelbusche.bsky.social reveals a role for the Alzheimer's-linked APP proteins in sustaining brain activity in healthy brains 🧠

The study provides insight into how their disruption could contribute to cognitive impairments👉https://buff.ly/KcwK7OQ

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Marc Aurel Busche @marcaurelbusche.bsky.social · Jun 8

Closing date is June 12th - please do apply in case of interest!

Marc Aurel Busche @marcaurelbusche.bsky.social · May 16

Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.

Apply here👇
shorturl.at/LpCAq

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

shorturl.at

Reposted by Marc Aurel Busche

Martin Fuhrmann @martinfuhrmann.bsky.social · Jun 1

It is out! Read how you achieve 1.7 mm deep 3-photon imaging in prefrontal cortex with dendritic spine resolution over a week.
www.nature.com/articles/s42...

Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution - Communications Biology

Three-photon in vivo imaging provides access to medial prefrontal cortex, hippocampus and spinal cord in mice at up to 1.7 mm depth of neurons, dendrites, spines, astrocytes and microglia.

www.nature.com

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Reposted by Marc Aurel Busche

Marc Aurel Busche @marcaurelbusche.bsky.social · May 16

Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.

Apply here👇
shorturl.at/LpCAq

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

shorturl.at

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Reposted by Marc Aurel Busche

UCL Faculty of Brain Sciences @uclbrainscience.bsky.social · May 16

A study led by Dr @marcaurelbusche.bsky.social (@uclqsion.bsky.social, @ukdri.ac.uk) sheds light on the earliest stage of Alzheimer’s, identifying which layers and cell types of the brain are first affected.

Deep-layer brain cells falter first in early Alzheimer’s

A study led by Dr Marc Aurel Busche (UK DRI at UCL, UCL Queen Square Institute of Neurology) sheds light on the earliest stage of Alzheimer’s, identifying which layers and cell types of the brain are…

buff.ly

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Marc Aurel Busche @marcaurelbusche.bsky.social · May 16

Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments.

Apply here👇
shorturl.at/LpCAq

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

shorturl.at

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Reposted by Marc Aurel Busche

UK Dementia Research Institute @ukdri.ac.uk · May 15

New research by @marcaurelbusche.bsky.social identifies where Alzheimer's begins in the brain, revealing which layers and cell types of the brain are first affected 🧠

The study opens up potential new pathways for targeted therapies👉https://buff.ly/4GlltQF

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Marc Aurel Busche @marcaurelbusche.bsky.social · May 8

Very grateful to @ukdri.ac.uk , Medical Research Council, @ukri.org , @curealzheimersfund.bsky.social , @brightfocus.bsky.social , @alzassociation.bsky.social for the invaluable support!

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Marc Aurel Busche @marcaurelbusche.bsky.social · May 8

Where does Alzheimer’s begin in the brain? Our study in @cp-neuron.bsky.social shows that the earliest amyloid-related neuronal dysfunction emerges selectively in deep cortical layers (layers 5/6), targeting fast-spiking parvalbumin interneurons via reductions in NPTX2.
www.cell.com/neuron/fullt...

Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo

Papanikolaou et al. show that deep-layer cortical neurons exhibit abnormally prolonged Ca2+ transients early in Alzheimer’s mouse models. This is linked to suppressed activity and altered tuning of fa...

www.cell.com

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Marc Aurel Busche @marcaurelbusche.bsky.social · May 3

Thank you so much for all the support.

Reposted by Marc Aurel Busche

Cure Alzheimer's Fund @curealzheimersfund.bsky.social · May 1

Impressive research. We are proud to support your work!

Marc Aurel Busche @marcaurelbusche.bsky.social · Apr 28

Grateful to @ukdri.ac.uk, medical research council, @ukri.org, @curealzheimersfund.bsky.social, @brightfocus.bsky.social, @alzassociation.bsky.social, and others for their support

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Reposted by Marc Aurel Busche

Rikesh Rajani @rikeshrajani.bsky.social · Apr 29

Delighted to have played a part in this work, now out in @cellpress.bsky.social, where we show how soluble high molecular weight tau from Alzheimer’s brain suppresses burst firing in hippocampal neurons.

Marc Aurel Busche @marcaurelbusche.bsky.social · Apr 28

Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory.
www.cell.com/cell/fulltex...

Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons

In mouse models, tau impairs neuronal complex spike bursting and associated network processes in hippocampus CA1 alongside CaV2.3 downregulation. Soluble high-molecular-weight tau species drive these ...

www.cell.com

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Marc Aurel Busche @marcaurelbusche.bsky.social · Apr 28

Grateful to @ukdri.ac.uk, medical research council, @ukri.org, @curealzheimersfund.bsky.social, @brightfocus.bsky.social, @alzassociation.bsky.social, and others for their support

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Marc Aurel Busche @marcaurelbusche.bsky.social · Apr 28

Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory.
www.cell.com/cell/fulltex...

Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons

In mouse models, tau impairs neuronal complex spike bursting and associated network processes in hippocampus CA1 alongside CaV2.3 downregulation. Soluble high-molecular-weight tau species drive these ...

www.cell.com

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Reposted by Marc Aurel Busche

UK Dementia Research Institute @ukdri.ac.uk · Apr 28

New research led by @marcaurelbusche.bsky.social has found that tau specifically disrupts a certain type of electrical activity in the hippocampus in Alzheimer's🧠

The findings unlock a key piece of the puzzle in understanding how toxic tau drives memory problems👏👉 buff.ly/yx8Rdk6

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Marc Aurel Busche @marcaurelbusche.bsky.social · Apr 9

Stelle als Oberärztin/Oberarzt: An der Universitären Altersmedizin FELIX PLATTER in Basel entsteht eine interdisziplinäre Verbindung von Klinik, Diagnostik und translationaler Forschung in Demenz/Alterspsychiatrie. Jetzt aktiv mitgestalten. www.felixplatter.ch/felixplatter...

Oberärztin oder Oberarzt Alterspsychiatrie

www.felixplatter.ch

Marc Aurel Busche @marcaurelbusche.bsky.social · Mar 4

Delighted to see the Synapsis Foundation & Race Against Dementia investing in the next generation of dementia researchers! Hopefully just a start of a growing UK-Swiss collaboration in this very important area.

Dementia Researcher @dementiaresearcher.bsky.social · Mar 3

🚨 Funding opportunity for dementia researchers! Up to CHF 100K/year for 5 years to support postdocs on their path to independence. Open to Swiss & EMBO institutions with Race Against Dementia. Apply by 7 April 2025.

www.dementiaresearcher.nihr.ac.uk/funding/fell...

Fellowships / Career Development Awards

Dementia Research Switzerland - Synapsis Foundation & Race Against Dementia Career Development / Fellowship Award competition - for researchers at Swiss Institutions

www.dementiaresearcher.nihr.ac.uk

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Marc Aurel Busche @marcaurelbusche.bsky.social · Feb 19

Delighted to see this news! Rikesh is an outstanding colleague - creative, dedicated, and absolutely committed to the fight against dementia. He will be a tremendous asset to the new BHF-UK DRI Centre. Wishing him every success - they couldn’t have picked a better person!

UK Dementia Research Institute @ukdri.ac.uk · Feb 19

Delighted to announce @rikeshrajani.bsky.social as the first Group Leader to join our flagship vascular dementia research centre with @thebhf.bsky.social 🎉👏

The Rajani Lab will investigate how the protective myelin sheath around brain cells is damaged in small vessel disease👉 buff.ly/4hIGaVM

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Reposted by Marc Aurel Busche

Charlie Arber @celarber.bsky.social · Jan 9

Link to British dementia work with @selinawray.bsky.social : link.springer.com/article/10.1...

Congrats to Rikesh and @marcaurelbusche.bsky.social for their oligodendrocyte paper: journals.plos.org/plosbiology/...

Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia - Acta Neuropathologica

Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known as BRI2) causes a C-ter...

link.springer.com

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Reposted by Marc Aurel Busche

Bowles Lab @bowleslab.bsky.social · Nov 26

On my way to UCL to give a seminar on all things #tau and #iPSC! Looking forward to hanging out with the @marcaurelbusche.bsky.social and @selinawray.bsky.social labs 😊

Struggling with my enormous Edinburgh-weather-appropriate but London-inappropriate coat on the Piccadilly line though 🫣

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