Lightnews — Scholar-powered news

María A. Moro

@mariangelesmoro.bsky.social

180 followers 110 following 180 posts

Researcher at CNIC, Madrid, Spain. Former Professor of Pharmacology at UCM. Professional interests: stroke, vascular dementia, neurovascular pathophysiology, cardiovascular risk factors and brain health, mentoring

Posts Media Videos Starter Packs

María A. Moro @mariangelesmoro.bsky.social · 1d

www.nature.com/articles/s41...

Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport - Signal Transduction and Targeted Therapy

Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport

María A. Moro @mariangelesmoro.bsky.social · 6d

www.science.org/doi/10.1126/...

Intercellular communication in the brain through a dendritic nanotubular network

Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite–dend...

www.science.org

María A. Moro @mariangelesmoro.bsky.social · 6d

www.cell.com/cell/fulltex...

A mast cell receptor mediates post-stroke brain inflammation via a dural-brain axis

Meningeal mast cells, via the receptor Mrgprb2/X2, orchestrate brain inflammation after stroke by recruiting and promoting the transfer of skull bone marrow neutrophils into the brain, highlighting th...

María A. Moro @mariangelesmoro.bsky.social · 6d

www.cell.com/cell/fulltex...

Mast cells regulate the brain-dura interface and CSF dynamics

Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces, specifically arachnoid cuff exit points. Their activation limits pathogen brain entry via histamine-induced vas...

María A. Moro @mariangelesmoro.bsky.social · 6d

www.ahajournals.org/doi/full/10....

Macrophage DNases Limit Neutrophil Extracellular Trap–Mediated Defective Efferocytosis in Atherosclerosis | Circulation Research

BACKGROUND: Neutrophil extracellular traps (NETs) contribute to atherosclerosis progression and are linked to adverse clinical outcomes such as myocardial infarction and stroke. Although the triggers ...

www.ahajournals.org

María A. Moro @mariangelesmoro.bsky.social · 19d

www.nature.com/articles/s41...

Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions - Nature Reviews Cardiology

In this Roadmap, Aggarwal and colleagues summarize current research and knowledge gaps on the relationship between sleep, circadian rhythms and cardiovascular resilience; highlight potential therapeut...

María A. Moro @mariangelesmoro.bsky.social · 19d

www.cell.com/cell/fulltex...

Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications

Analysis of the conserved intercellular interactome in human vascular dementia and in a mouse model reveals the Serpine2-Lrp1 and CD39-A3AR signaling axes as potential therapeutic targets.

María A. Moro @mariangelesmoro.bsky.social · 20d

www.nature.com/articles/s41...

Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature

Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

María A. Moro @mariangelesmoro.bsky.social · 21d

www.pnas.org/doi/10.1073/...

The redox rhythm gates immune-induced cell death distinctly from the genetic clock | PNAS

Organisms use circadian clocks to synchronize physiological processes to anticipate the Earth’s day-night cycles and regulate responses to environm...

María A. Moro @mariangelesmoro.bsky.social · 23d

www.science.org/doi/10.1126/...

Integrating spatial and single-cell transcriptomics to characterize the molecular and cellular architecture of the ischemic mouse brain

The transcriptomic landscape was characterized at single-cell and spatial resolution of the ischemic mouse brain.

www.science.org

María A. Moro @mariangelesmoro.bsky.social · Sep 6

www.nature.com/articles/s41... @andyshihlab.bsky.social 👏🏻👏🏻👏🏻👏🏻

Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience

How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...

María A. Moro @mariangelesmoro.bsky.social · Sep 5

www.cell.com/cell/fulltex...

Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling

Vasodilatory signals are rapidly communicated across long distances by endothelial-endothelial gap junctions, enabling coordinated dilation of the arterial network during neurovascular coupling.

María A. Moro @mariangelesmoro.bsky.social · Sep 4

www.neurology.org/doi/10.1212/...

Association Between Consumption of Low- and No-Calorie Artificial Sweeteners and Cognitive Decline | Neurology

Background and ObjectivesConsumption of low- and no-calorie sweeteners (LNCSs) has been associated with adverse health outcomes. However, little is known about the association between consumption of L...

www.neurology.org

María A. Moro @mariangelesmoro.bsky.social · Sep 3

www.cell.com/neuron/fullt...

Reconstructed cell-type-specific rhythms in human brain link Alzheimer’s pathology, circadian stress, and ribosomal disruption

Hollis, Sharma, et al. examine cell-type-specific diurnal rhythms in control and Alzheimer’s disease (AD)-affected human brains. They find that AD preserves core clock function but disrupts output rhy...

María A. Moro @mariangelesmoro.bsky.social · Aug 29

www.ahajournals.org/doi/full/10....

Immunoregulatory Endothelial Cells Interact With T Cells After Myocardial Infarction | Circulation Research

BACKGROUND: Endothelial cells (ECs) play pivotal roles in maintaining cardiac blood supply and regulating inflammation by acting as gatekeepers for immune cell activity. This study unveils a novel imm...

www.ahajournals.org

María A. Moro @mariangelesmoro.bsky.social · Aug 25

www.nature.com/articles/s41...

Plasma proteomics links brain and immune system aging with healthspan and longevity - Nature Medicine

In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong predictors of healthsp...

María A. Moro @mariangelesmoro.bsky.social · Aug 21

www.ahajournals.org/doi/full/10....

Vascular Contributions to Cognitive Impairment and Dementia in the United States: Prevalence and Incidence: A Scientific Statement From the American Heart Association | Stroke

Vascular contributions to cognitive impairment and dementia (VCID) are common and may be the most preventable cause of clinically significant cognitive decline. However, an estimate of the prevalence ...

www.ahajournals.org

María A. Moro @mariangelesmoro.bsky.social · Aug 20

rupress.org/jem/article/...

Antibiotics unleash neuroinflammation | Journal of Experimental Medicine | Rockefeller University Press

The gut microbiome limits neuroinflammation and neurocognitive decline in acute graft-versus-host disease by modulating microglial activation via a mechani

María A. Moro @mariangelesmoro.bsky.social · Aug 6

www.cell.com/neuron/fullt...

Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau

Chen et al. show that in AD mouse models, chronic activation of astrocytic PERK-eIF2a signaling suppresses protein synthesis and disrupts perivascular AQP4 localization via CK2-dependent mechanisms. I...

María A. Moro @mariangelesmoro.bsky.social · Aug 6

www.nature.com/articles/s41...

The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience

Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

María A. Moro @mariangelesmoro.bsky.social · Aug 6

www.cell.com/cell-metabol...

The foam cell-derived exosomes exacerbate ischemic white matter injury via transmitting metabolic defects to microglia

The pathomechanism of atherosclerosis as an independent risk factor for vascular cognitive impairment remains unclear. Zhang et al. find that macrophage-derived foam cells in atherosclerotic plaques t...

María A. Moro @mariangelesmoro.bsky.social · Jul 29

jamanetwork.com/journals/jam...

Structured vs Self-Guided Multidomain Lifestyle Interventions for Global Cognitive Function

This randomized clinical trial assesses the effect of structured vs self-guided multidomain lifestyle interventions on changes in global cognitive function over 2 years among older adults at risk of c...

jamanetwork.com

María A. Moro @mariangelesmoro.bsky.social · Jul 21

elpais.com/opinion/2025... 👏🏻👏🏻👏🏻👏🏻

Antes del colesterol

El descubrimiento de una molécula que produce problemas cardiovasculares demuestra la utilidad de la inversión en ciencia a largo plazo

María A. Moro @mariangelesmoro.bsky.social · Jul 20

academic.oup.com/brain/advanc...

Sleep, pericyte subtypes and cognitive decline in adults with and without Alzheimer’s disease

By analysing post-mortem RNA sequencing data from the brains of over 1000 older adults, Hamid et al. found that individuals with more fragmented sleep—meas

academic.oup.com

María A. Moro @mariangelesmoro.bsky.social · Jul 17

www.nature.com/articles/s41...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.