Maryse Berkhout
@maryseberkhout.bsky.social
3.2K followers 9.8K following 37 posts
Microbes & mucus 🤩 | Gut Microbial Ecology | Wageningen University, NL
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maryseberkhout.bsky.social
📚 I am happy to share that our latest paper is out in Glycobiology!

🦠 We developed a synthetic community of human gut microbes that completely degrades mucin glycans.

🔬 We studied its enzymes and ecological interactions in vitro.

#glycotime #mucin #microbiome

academic.oup.com/glycob/artic...
Mucin-driven ecological interactions in an in vitro synthetic community of human gut microbes
Abstract. Specific human gut microbes inhabit the outer mucus layer of the gastrointestinal tract. Certain residents of this niche can degrade the large an
academic.oup.com
Reposted by Maryse Berkhout
womensartbluesky.bsky.social
Elin Thomas, UK textile artist who uses embroidery/crochet to create unique work resembling petri dishes and bacteria spores #womensart
Photo looking down on four petri dishes, neatly arranged, with what resembles bacteria and mould growing inside created with crochet and embroidery
maryseberkhout.bsky.social
👩‍🎓 I am a doctor now! #PhDone @w-u-r.bsky.social @mib-wur.bsky.social

❤️ Thank you everyone for making the big day - and the entire PhD journey - such a memorable one

🦠 Looking forward to what's next #microsky

📸 Picture by en.phddefencephoto.com
Group photo of PhD defence committee, young doctor and paranymphs
Reposted by Maryse Berkhout
natmicrobiol.nature.com
#Editorial

In this month's editorial, we talk about microbial foods. Bacteria and fungi can augment the flavour, composition and sustainability of foods, but more research is needed to push microbial foods — and consumer palates — to new heights.

#MicroSky 🦠

www.nature.com/articles/s41...
Microbes on the menu - Nature Microbiology
Bacteria and fungi can augment the flavour, composition and sustainability of foods, but more research is needed to push microbial foods — and consumer palates — to new heights.
www.nature.com
maryseberkhout.bsky.social
💡 Curious how we applied a synthetic community to study interactions between baby gut microbes and a lot of different sugars?

📖 I wrote a blog for the #FEMSmicroBlog to explain!

🦠 #microsky #microbiomesky #glycotime

fems-microbiology.org/femsmicroblo...
Interactions between a mother’s milk and baby's microbes
To explore the interactions between a baby's gut microbes and mother's milk, a study applies a synthetic community of glycan degraders and cross-feeders.
fems-microbiology.org
Reposted by Maryse Berkhout
femsmicro.org
FEMS @femsmicro.org · Aug 19
Milk sugars from the mother play crucial roles in the development of a baby's gut microbiome. 🍼

To explore the interactions between sugars and the gut microbes in an infant, a study applies a community of glycan degraders and cross-feeders. #FEMSmicroBlog #FascinatingMicrobes
About the interactions between sugars from mother’s milk and the baby’s microbes
To explore the interactions between different sugars and the gut microbes in an infant, a new study applies a synthetic community consisting of glycan degraders and cross-feeders.
buff.ly
Reposted by Maryse Berkhout
sheencr.bsky.social
Nice! A bacterium that is poorly described in literature can boost the function of check point therapy inhibitors in mice- shows the potential of microbiome that we have only just started to tap into -summary here 🧪 #MicroSky #ImmunoSky 🧵
Found: a human gut microbe that makes cancer therapy more effective in mice
Cancer therapies called checkpoint inhibitor drugs, which ratchet up the immune system, work better when this bacterium is around.
www.nature.com
maryseberkhout.bsky.social
However, when mucin was present, A. muciniphila thrived happily. 😎

GOS/FOS, which are often added as a prebiotic to infant formula, induced a similar microbial composition as HMOs.🍼

Although the microbial composition differed between all glycans, mucin was the main driver of dissimilarities.↔️
maryseberkhout.bsky.social
Even though the microbes in our synthetic community have similar glycan-degrading enzymes, their ability to grow in a community differs per glycan. ✂️

For example, Akkermansia muciniphila can grow on HMOs in monoculture, but was unable to compete with more specialist HMO degraders in the community.🔍
maryseberkhout.bsky.social
Another publication in @femsjournals.bsky.social @femsmicro.org 🔬

How do glycans shape the infant gut microbiota? 👶

With a novel in vitro synthetic community we studied the interplay between microbes and HMOs, mucin glycans and GOS/FOS.🍼🤱🦠

#microsky #glycotime

doi.org/10.1093/fems...
Milk and mucin glycans orchestrate a synthetic infant gut microbiota structure
Dietary and gut glycans drive the composition of an in vitro synthetic community of infant gut microbes.
doi.org
maryseberkhout.bsky.social
Thank you! We will definitely keep that in mind for future studies!