banner
massspecpro.bsky.social
Mike Goodwin
@massspecpro.bsky.social
480 followers 250 following 160 posts
Senior Scientist @ Thermo (San Jose)
Posts Media Videos Starter Packs
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 5d
dx.doi.org/10.1021/acs....
dx.doi.org
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 5d
dx.doi.org/10.1021/acs....
dx.doi.org
1
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 5d
dx.doi.org/10.1021/jasm...
Improving the Quadrupole to Ion Mobility Region in a Digital Quadrupole/Ion Mobility/Orbitrap Mass Spectrometer
A quadrupole/drift tube ion mobility/Orbitrap instrument requires pumping from atmosphere to 10–5 Torr in the quadrupole analyzer region, back to 1 Torr for the drift tube, and a return to 10–5 Torr f...
dx.doi.org
2
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 8d
pubs.acs.org/doi/10.1021/...
Segmented-Field-Gradient-Focusing Ion Guide for Simultaneously Improved Ion Transfer across a Wide Mass Range and Enhanced Sensitivity
The sensitivity of the atmospheric pressure ionization mass spectrometer (API-MS) has been improved owing to the advancement in the atmospheric pressure interface. However, ion scattering losses in th...
pubs.acs.org
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 12d
pubs.acs.org/doi/pdf/10.1...
SLIMPHONY: A SLIM-Based Instrument That Orchestrates Complex Ion Mobility–Mass Spectrometry Experiments
The inherent heterogeneity of biological macromolecules offers a unique challenge for analysis. The combination of ion mobility (IM) and mass spectrometry (MS) is sensitive to the size, shape, and dyn...
pubs.acs.org
2
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 15d
No details from me.
1 2
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 21d
I believe the term "electrophoretic mobility" is common in the field. I heard CE being likened to "liquid phase ion mobility" many times in my work at 908 Devices. However, it feels a bit strange to be dropped in a paper's title like this.
1 3
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 25d
pubs.acs.org/doi/10.1021/...
Real-Time Instrument Control across Multiple Orbitrap Platforms through a Single Software Interface
Applications using real-time spectral analysis and real-time instrument control have emerged in recent years as powerful tools to improve the capabilities and sensitivity of mass spectrometers. Softwa...
pubs.acs.org
1 1 3
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 25d
pubs.acs.org/doi/10.1021/...
Improving Proteomic Dynamic Range with Multiple Accumulation Precursor Mass Spectrometry
Orbitrap (OT)-based mass spectrometer platforms are a gold standard in high-resolution mass spectrometry, where their primary disadvantage is slower-scanning speed in comparison to time-of-flight or l...
pubs.acs.org
1
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 28d
They showed this at asms years ago.
1
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 28d
pubs.acs.org/doi/10.1021/...
Enhanced Charge-Sensitive Amplifier Performance Leads to Substantially Reduced CD-MS Measurement Times for Charge State Resolution
In charge detection mass spectrometry (CD-MS) ions are trapped in an electrostatic linear ion trap (ELIT) where they oscillate back and forth through a conducting cylinder. The oscillating ions induce...
pubs.acs.org
1
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 28d
www.sciencedirect.com/science/arti...
Comparison of the results of the aberration approach for the calculation of electrostatic TOF mass analyzers with simulation in SIMION
In the last few years, high-resolution time-of-flight mass analyzers (TOF-MA) have been intensively developed. Their development requires tools that p…
www.sciencedirect.com
1
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · 29d
chemrxiv.org/engage/chemr...
Manipulation of Electrospray-Produced Protein and Peptide Ions with Acoustic Fields at Atmospheric Pressure
The coupling of electrospray ionization (ESI) with the newly discovered acoustic ion manipulation (AIM) phenomenon is demonstrated for biopolymer analytes, including peptides, proteins, and DNA. It is...
chemrxiv.org
2
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · Sep 7
Nice. What made the difference?
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · Sep 7
Particularly tricky m/z?
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · Sep 5
www.sciencedirect.com/science/arti...
Two-Dimensional Tandem Mass Spectrometry in a Linear Quadrupole Ion Trap Using Consecutive Product Ion Sweeps
Two-dimensional tandem mass spectrometry (2D-MS/MS) is a powerful analysis technique which can quickly produce a map of all precursor-product ion rela…
www.sciencedirect.com
1 4
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · Sep 2
The point differential in Bill Belichick's first game at UNC might end up larger than the age differential in his relationship, which is saying something. #belichick
1
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · Sep 1
Seems like many groups are realizing the inefficiencies of traditional TOF designs and working on one of the issues (m/z dispersion when sending ions out of an rf trapping device into a pusher).
kkmurray.bsky.social
Kermit Murray @kkmurray.bsky.social · Aug 31
(IJMS) Extended m/z Range of Coaxial Linear Ion Trap/Time-of-flight Mass Spectrometry Using Dynamic Electric Field Ejection: Publication date: Available online 30 August 2025

Source: International Journal of Mass Spectrometry

Author(s): Yixue Cao, Xuesong Zhang, Jilong Wang,… #ijms #MassSpecRSS
Extended m/z Range of Coaxial Linear Ion Trap/Time-of-flight Mass Spectrometry Using Dynamic Electric Field Ejection
Publication date: Available online 30 August 2025 Source: International Journal of Mass Spectrometry Author(s): Yixue Cao, Xuesong Zhang, Jilong Wang, Chenxin Wu, Lei Hua, Ping Chen, Haiyang Li
dlvr.it
3
Reposted by Mike Goodwin
kkmurray.bsky.social
Kermit Murray @kkmurray.bsky.social · Aug 27
(IJMS) Next Generation MasSpec Pen Technology: Innovations in Instrumentation and Medical Device Development for Intraoperative Use: Publication date: Available online 26 August 2025

Source: International Journal of Mass Spectrometry

Author(s): Charles A. Wolfe, Sydney… #ijms #MassSpecRSS
Next Generation MasSpec Pen Technology: Innovations in Instrumentation and Medical Device Development for Intraoperative Use
Publication date: Available online 26 August 2025 Source: International Journal of Mass Spectrometry Author(s): Charles A. Wolfe, Sydney Povilaitis, Michael F. Keating, Ashley E. Montgomery, Bryan M. Burt, Amir A. Jazaeri, Livia S. Eberlin
dlvr.it
3 6
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · Aug 21
You can dm me.
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · Aug 17
www.sciencedirect.com/science/arti...
Demonstration of a Nested Electrostatic Linear Ion Trap for Flexibility in Selecting Analyzer Figures-of-Merit
An electrostatic linear ion trap (ELIT) is used to trap ions between two ion mirrors with image current detection by central detection electrode. Tran…
www.sciencedirect.com
1 1
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · Aug 14
analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/...
Simulation and Development of an Ion Funnel for Miniature Mass Spectrometers
Rationale Miniature mass spectrometers are increasingly used in portable and on-site analysis due to their compact size and light weight. However, miniaturization, higher operating gas pressure, and...
analyticalsciencejournals.onlinelibrary.wiley.com
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · Aug 14
Collision-Induced Unfolding of High-m/z Native-like Protein Ions within a Trapped Ion Mobility Spectrometer

chemrxiv.org/engage/chemr...
1
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · Aug 13
pubs.acs.org/doi/10.1021/...
Long-Term System Suitability Evaluation for Mass Accuracy in the Analysis of Small Molecules by High-Resolution Mass Spectrometry
High-resolution mass spectrometry (HRMS) is critical for the identification and characterization of (un)known organic chemicals. In this regard, ensuring high mass accuracy in HRMS instruments is esse...
pubs.acs.org
1
massspecpro.bsky.social
Mike Goodwin @massspecpro.bsky.social · Aug 9
pubs.acs.org/doi/10.1021/...
Dynamic Quadrupole Selection to Associate Precursor Masses with MS/MS Products in Data-Independent Acquisition
Data-independent acquisition (DIA) mass spectrometry facilitates high-throughput, reproducible bottom-up proteomic analyses. Typically, DIA methods coselect multiple precursor ions within a wide selec...
pubs.acs.org
1 5