Mathias Jucker
@mathiasjucker.bsky.social
80 followers
30 following
11 posts
Biomedical Researcher
Professor @dzne.science @hih-tuebingen.bsky.social
Tübingen 🇩🇪 & Zürich 🇨🇭
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Mathias Jucker
@mathiasjucker.bsky.social
· May 16
Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders
A tricyclic depletion protocol allows for microglia replacement without preconditioning and mitigates pathology in mouse models of neurodegeneration.
www.science.org
Mathias Jucker
@mathiasjucker.bsky.social
· Mar 20
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled ...
Amyloid plaque removal by monoclonal antibody therapies slows clinical progression in symptomatic Alzheimer's disease; however, the potential for dela…
sciencedirect.com
Mathias Jucker
@mathiasjucker.bsky.social
· Feb 22
The unfolding story of protein mis-folding causing Alzheimer’s disease in recipients of human pituitary growth hormone
Abstract. Human growth hormone (hGH) has been in clinical use for children with GH deficiency (GHD) since the late 1950s. The original formulations were co
doi.org
Mathias Jucker
@mathiasjucker.bsky.social
· Jan 14
In vivo base editing extends lifespan of a humanized mouse model of prion disease - Nature Medicine
An in vivo base editing approach targeting the PRNP gene led to a 52% increase in the lifespan of mouse models inoculated with the most common sporadic and genetic types of human pathogenic prion isol...
doi.org
Mathias Jucker
@mathiasjucker.bsky.social
· Dec 11
Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer’s disease - Nature Communications
This study supports neurofilament light chain protein (NfL) in both cerebrospinal fluid (CSF) and blood as an early marker of neurodegeneration in Alzheimer’s disease but suggests that NfL in CSF may ...
doi.org
