Matthias Drosten
@matthiasdrosten.bsky.social
Principal Investigator at Centro de Investigación del Cáncer (CIC), Salamanca, Spain | RAS signaling and lung cancer
This research was supported by the Agencia Estatal de Investigación/Ministerio de Ciencia, Innovación y Universidades, the Scientific Foundation of the Spanish Association Against Cancer, Instituto de Salud Carlos III, Comunidad de Madrid and the European Research Council.
November 26, 2025 at 10:26 AM
This research was supported by the Agencia Estatal de Investigación/Ministerio de Ciencia, Innovación y Universidades, the Scientific Foundation of the Spanish Association Against Cancer, Instituto de Salud Carlos III, Comunidad de Madrid and the European Research Council.
Restoration of Capicua repressor activity or silencing of Capicua target genes ETV4 and ETV5 restores the sensitivity to trametinib. In addition, absence of Capicua creates new vulnerabilities that can be exploited to overcome resistance.
November 26, 2025 at 10:26 AM
Restoration of Capicua repressor activity or silencing of Capicua target genes ETV4 and ETV5 restores the sensitivity to trametinib. In addition, absence of Capicua creates new vulnerabilities that can be exploited to overcome resistance.
We show that absence of Capicua suppresses the requirement for Kras oncogene amplification during lung tumor development, leading to more efficient transformation of bronchiolar Club cells and resistance to MAPK pathway inhibitors.
November 26, 2025 at 10:26 AM
We show that absence of Capicua suppresses the requirement for Kras oncogene amplification during lung tumor development, leading to more efficient transformation of bronchiolar Club cells and resistance to MAPK pathway inhibitors.