New preprint from our lab:

OsTIR1F74G Expression Controls Basal and Auxin-Induced Degradation Rates of the AID System in Yeast
Julius A Fulleborn, Andrei Seica, Andreas Milias-Argeitis, Matthias Heinemann
bioRxiv 2025.07.11.664329; doi: doi.org/10.1101/2025...

Proteins of amino acid metabolism form large structures and determine diffusion in the cytoplasm!

Our 7-year-long tour-de-force is now out on Bioxriv www.biorxiv.org/content/10.1...

Thanks everyone involved! And especially to Jose Losa who pioneered this!

Alternatives to photorespiration: A system-level analysis reveals mechanisms of enhanced plant productivity | Science Advances www.science.org/doi/10.1126/...

... And such a people, deprived of the power to think and judge, is, without knowing and willing it, completely subjected to the rule of lies. With such a people, you can do whatever you want." Hannah Arendt | (1906-1975) | German philosopher

"This constant lying is not aimed at making the people believe a lie, but at ensuring that no one believes anything anymore. A people that can no longer distinguish between truth and lies cannot distinguish between right and wrong...."

I have an opening for a PhD student in my lab @unigroningen.bsky.social to explore the dynamics of the cytoplasm and its connection with metabolism. Application until March 18. For more info: heinemannlab.eu/wp-content/u...

We are a cool lab with amazing, happy people. 😃

Please distribute.

Now published in Current Biology @currentbiology.bsky.social. Free access in the next 50 days via authors.elsevier.com/a/1kWGb_LsQS...

6/6 Shoutout: Big thanks to Xiang Li @xiang-l.bsky.social and Robson de Assis Souza. This has been a long journey! I am super happy with the final result and you can both be very proud of it!

5/6 📚 Conclusion: Our study sheds light on how glucose metabolism governs yeast cellular characteristics. Understanding these relationships could significantly influence biotechnological applications in fermentation processes. 🍞🥂 #Biotechnology #CellMorphology

4/6 ⚗️ Physiological Correlations: Our results also revealed strong relationships between glucose uptake rates and key physiological parameters, including Ethanol Production Rate (EPR) and Biomass Yield (Yx/s). Larger cells have fermentation capabilities! 🍷 #Fermentation

3/6 🔗 Causal Relationship: Importantly, we demonstrated that glucose metabolism determines cell morphology rather than the other way around. This suggests a fundamental principle in yeast biology, where metabolism shapes cellular features. 💡 #CellBiology

2/6 🔍 Key Finding: We discovered a universal principle: Larger cells have a higher volume-specific (!) glucose uptake rate.

1/6 🧫 Introduction: We recently explored how glucose metabolism rates influence cell morphology across various yeast species. Our findings underscore the intricate connections between metabolism and cell size. #YeastResearch #Metabolism

🧬✨ Our Findings on Glucose Metabolism and Yeast Cell Morphology ✨🧬Now published in Current Biology @currentbiology.bsky.social. Free access in the next 50 days via authors.elsevier.com/a/1kWGb_LsQS...

I deactivated my X account. It will now be deleted in 30 days. It feels good. I hope that many others will do the same.