mattmcneil86.bsky.social
Matt McNeil
@mattmcneil86.bsky.social
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mattmcneil86.bsky.social
Matt McNeil @mattmcneil86.bsky.social · May 30
Really excited that our group was able to contribute to this awesome work from Bing Zhang and Zihe Rao solving the structure and assembly of the MmpS5L5 efflux pump from Mtb!!

www.nature.com/articles/s41...
Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis - Nature Communications
The MmpL5/MmpS5 efflux system is crucial for drug extrusion and siderophore export in M. tuberculosis. Here, the authors report its high-resolution cryo-EM structures, revealing a unique trimeric asse...
www.nature.com
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mattmcneil86.bsky.social
Matt McNeil @mattmcneil86.bsky.social · Apr 24
Super excited that this manuscript investigating verapamil potentiation of bedaquiline in M. tuberculosis is now in PNAS!! Great collaborative effort with Lalita Ramakrishnan and her team at the MRC-LMB!!

www.pnas.org/doi/10.1073/...

@pnas.org
@universityofotago.bsky.social
Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity | PNAS
Bedaquiline is the cornerstone of a new regimen for the treatment of drug-resistant tuberculosis. However, its clinical use is threatened by the em...
www.pnas.org
7 10
Reposted by Matt McNeil
feargalr.bsky.social
Feargal Ryan @feargalr.bsky.social · Apr 2
Delighted our study (7+ years in the making) is out today in Nature. In a nutshell, 48 hours of antibiotics in week 1 led to impaired vaccine responses up to 15 months later in infants. We show (in-vivo) a probiotic can fix it #microbiome #science #immunology
www.nature.com/articles/s41...
Bifidobacteria support optimal infant vaccine responses - Nature
Neonatal antibiotic use is shown to reduce immune response to infant vaccines, accompanied by reduced abundance of Bifidobacteria in the gut microbiota, with experiments in mice indicating that probio...
www.nature.com
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