Matt Foster
@mattwfoster.bsky.social
Proteomics, humor, bbq, gravel riding, hiking, violin, gardening. Durham, NC
Focused (now) on analyzing whole 🩸 in sepsis. Pulmonary, Allergy and Critical Care Medicine, and Proteomics and Metabolomics Core Facility, Duke University
Focused (now) on analyzing whole 🩸 in sepsis. Pulmonary, Allergy and Critical Care Medicine, and Proteomics and Metabolomics Core Facility, Duke University
Long read proteomics, eh @proteomicsnews.bsky.social? What’s that?
January 27, 2026 at 3:30 PM
Long read proteomics, eh @proteomicsnews.bsky.social? What’s that?
Thought of you when I was using the self checkout and got flagged for putting my Cheerios and reusable bag into the bagging area at the same time. When they cleared me, there was an overhead video of my “maneuver”. Are they using AI to prevent shoplifting?
January 22, 2026 at 10:37 PM
Thought of you when I was using the self checkout and got flagged for putting my Cheerios and reusable bag into the bagging area at the same time. When they cleared me, there was an overhead video of my “maneuver”. Are they using AI to prevent shoplifting?
We can automate data transfer, file conversion and processing in Spectronaut, so that is usually the next step. Then we’re looking at TIC in htrms converter and IDs, XIC extraction width, etc.
January 22, 2026 at 10:32 PM
We can automate data transfer, file conversion and processing in Spectronaut, so that is usually the next step. Then we’re looking at TIC in htrms converter and IDs, XIC extraction width, etc.
If it’s a multi-day study, sometimes targeted extraction in Skyline to look at rt stability, mass accuracy and peptide intensity. Quick and dirty is just to look at file sizes, which often alerts to a bad sample or gradual loss in ion current. 1/2
January 22, 2026 at 10:32 PM
If it’s a multi-day study, sometimes targeted extraction in Skyline to look at rt stability, mass accuracy and peptide intensity. Quick and dirty is just to look at file sizes, which often alerts to a bad sample or gradual loss in ion current. 1/2
Ooh that's an idea. I'm missing ASMS but looking for another conference for late summer/early fall.
January 19, 2026 at 10:13 PM
Ooh that's an idea. I'm missing ASMS but looking for another conference for late summer/early fall.
24 h live stream with callers
January 9, 2026 at 11:59 PM
24 h live stream with callers
My lazy recipe is to cut the leaves cross-wise, stuff them in an instant pot with smoked pork necks or hocks, add some water and red pepper flakes and cook for ~45-60 min. Sometimes I’ll add sugar after they are cooked to sweeten but the molasses is a good tip.
January 1, 2026 at 5:29 PM
My lazy recipe is to cut the leaves cross-wise, stuff them in an instant pot with smoked pork necks or hocks, add some water and red pepper flakes and cook for ~45-60 min. Sometimes I’ll add sugar after they are cooked to sweeten but the molasses is a good tip.
Also you have become the clickbait....
December 31, 2025 at 1:02 PM
Also you have become the clickbait....
Wow you weren’t kidding 🤯.
December 31, 2025 at 12:42 PM
Wow you weren’t kidding 🤯.
I agree. Ditch TMT. Fini.
December 15, 2025 at 11:31 PM
I agree. Ditch TMT. Fini.
Music beat science, but by how much, not sure.
December 7, 2025 at 2:23 AM
Music beat science, but by how much, not sure.
I guess you in theory have a slightly cheaper assay if you inject direct from a plate (versus load on Evotips), but is there any other advantage of the Neo?
December 4, 2025 at 1:32 PM
I guess you in theory have a slightly cheaper assay if you inject direct from a plate (versus load on Evotips), but is there any other advantage of the Neo?
Actually nvm. Thats how I deliver it to the peek tee haha. Using an old Aux pump. But post column :)
December 2, 2025 at 10:55 PM
Actually nvm. Thats how I deliver it to the peek tee haha. Using an old Aux pump. But post column :)
I wouldn’t put it through an LC. Maybe that’s been the source of some problems.
December 2, 2025 at 10:45 PM
I wouldn’t put it through an LC. Maybe that’s been the source of some problems.
However, I would keep it clear of any instrument that is used for small molecules or is very sensitive to impurities in calmix.
December 2, 2025 at 10:21 PM
However, I would keep it clear of any instrument that is used for small molecules or is very sensitive to impurities in calmix.
We’ve been using it post-column for microflow (1 mm * 100 ul/min) for awhile on Orbitraps. Actually I think it keeps things cleaner and service engineers have never complained. 1/2
December 2, 2025 at 10:18 PM
We’ve been using it post-column for microflow (1 mm * 100 ul/min) for awhile on Orbitraps. Actually I think it keeps things cleaner and service engineers have never complained. 1/2
Neat. Will have to test PrA/DMSO next I'm on running on an instrument that I won't get in trouble for abusing (and has already seen lots of DMSO). Maybe I won't need 60 ugs on column :).
December 1, 2025 at 11:02 PM
Neat. Will have to test PrA/DMSO next I'm on running on an instrument that I won't get in trouble for abusing (and has already seen lots of DMSO). Maybe I won't need 60 ugs on column :).