I am excited to share this pre-print! We modeled exposure to the heavy metal lead in human iPSC organoids and discovered that Pb shifts lineage trajectories—promoting neurogenesis at the expense of astrogenesis. See the 🧵below. Thank you to my incredible mentor and co-authors @sloanlab.bsky.social!

Of course, we were specifically looking at multipotent radial glia. When we look at committed astrocytes and neurons, Pb exposure is associated with increases in cell death!

Hi Kelsey! This is likely a phenomenon that only occurs in development, specifically around the time of the gliogenic switch. We observed the suppression of gliogenesis in GW16-20 radial glial cells, whereas in GW21+ cells the phenotype was attenuated.

to the PIs, is it advisable going on job market this fall when things are seemingly falling apart, or riding the postdoc wave for longer (while funding lasts) for some semblance of stability?

I dunno about you guys but this is one of those very rare times when neighbors and mothers-in-law suddenly and unsolicitedly ask about our business, ie “is that IDC thing going to ruin science”. It matters that you convey the right message and the accurate message. Not your unverified grievances.

A lovely quick read--sweet, funny, honest. ❤️ Congrats on your 1st year @dgonzales1990.bsky.social!

I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...

added! ❤️

Keep in touch with NINDS #DSPANscholars here 🧠 Reply or DM to be added! go.bsky.app/TQdWJr3

last minute edit to this weekend's poster

Hi #neuroscience community! This is one of my favorite posts ever. In close collaboration with @liddelowsa.bsky.social and Ye Zhang, we've built a new tool that we are eager to share! www.webseq.net

NINDS just launched a $50K prize competition for early-career scientists championing research rigor beyond their normal duties. Do you organize workshops, journal clubs, or do work to try and shift culture? This could be you.
www.challenge.gov?challenge=ni...

added you!

On the topic of funding absurd research by NIH and other federal agencies, they funded scientists:
- watching flies fuck
- giving rats massages
- spending years on why jellyfish glow
- tracking penguin poop from space
- using horseshoe crab blood

We need a #dspanscholar starter pack! Tag people here so we can start one 🧠 @fleabrained.bsky.social @crmcdermott.bsky.social @neubadah.bsky.social @krissylyon.bsky.social @denagoldblatt.bsky.social @elucero.bsky.social