@mauroesguerroto.bsky.social
Reposted
Cryogenic electron microscopy showed for the first time that large RNA complexes can assemble without the help of proteins, expanding our understanding of RNA folding and function.
www6.slac.stanford.e...
www6.slac.stanford.e...
SLAC, Stanford researchers discover large protein-free RNA structures
Cryogenic electron microscopy showed for the first time that large RNA complexes can assemble without the help of proteins.
www6.slac.stanford.edu
June 4, 2025 at 4:22 PM
Cryogenic electron microscopy showed for the first time that large RNA complexes can assemble without the help of proteins, expanding our understanding of RNA folding and function.
www6.slac.stanford.e...
www6.slac.stanford.e...
Reposted
Nice summary of our ipSAE score for rescoring protein-protein and protein/nucleic-acid interactions in AF2, AF3, and Boltz-1. It works better than ipTM for full-length Uniprot sequences.
As @rolanddunbrack.bsky.social recently discovered, one of the issues with the ipTM score used AF2 to represent the ipTM score is that it is biased by disordered regions of the protein outside the binding interface. To address this, he implemented a new metric, ipSAE.
levitate.bio/alphafold/mu...
levitate.bio/alphafold/mu...
Fixing the Flaws in AlphaFold’s Interface Scoring: Meet Dunbrack’s ipSAE
Predicting protein-protein interactions Since AlphaFold2 was published, one of the major applications of the model was accurately predicting the structure of protein-protein interactions. By taking as...
levitate.bio
June 3, 2025 at 10:50 PM
Nice summary of our ipSAE score for rescoring protein-protein and protein/nucleic-acid interactions in AF2, AF3, and Boltz-1. It works better than ipTM for full-length Uniprot sequences.