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Reposted by Molecular Cell Biology and Immunology Lab

Alsya Affandi @jubillix.bsky.social · 22d

After a summer break, @mcbi-amsumc.bsky.social #SingleCellClub is back! Looking forward to Fern Bosada-Musselwhite's talk on quantifying heart extracellular matrix using (light sheet) microscopy 🔬 tomorrow!

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Jun 19

On the 1st day of the @cancercenterams.bsky.social annual conference Lotte De Winde presented her recently published data on the development of lymphoma-on-a-chip model to study the role of fibroblasts in this pathology! You can find the publication here doi.org/10.1016/j.mt...

Lotte de Winde standing in front of her title slide « Lymphoma on a chip model reveals that lymph node stromal cells promote B cell lymphoma survival and migration »

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Reposted by Molecular Cell Biology and Immunology Lab

Carlos del Río, MD, FACP, FIDSA @docdelrio.bsky.social · Jun 5

Today marks the 44th anniversary of the publication in the MMWR of a new syndrome that we now know as AIDS www.cdc.gov/mmwr/preview... (MMWR 1981;30:250--2). Much progress since then but much remains to be done.

Pneumocystis Pneumonia --- Los Angeles

www.cdc.gov

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Reposted by Molecular Cell Biology and Immunology Lab

Sebastiaan van Heesch @sebastiaanvheesch.bsky.social · May 16

### PhD position alert ###

Please repost!

I'm excited to announce a new *PhD position* within our group.

We are looking for a super-motivated candidate with a solid basis in wet- and dry-lab research. Apply now & make sure to include all docs!

werkenbijprinsesmaximacentrum.nl/en/vacancy/p...

PhD Position: Unraveling the Dark Proteome in Pediatric Cancer - Werken bij Prinses Maxima Centrum

Background For decades, vast stretches of the genome were dismissed as non-functional ‘junk’. However, our group and others have revealed that these regions harbor numerous non-canonical open reading ...

werkenbijprinsesmaximacentrum.nl

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · May 15

The next single cell club is happening today!!

Alsya Affandi @jubillix.bsky.social · May 14

Don't miss tomorrow's talk by Anneloes van Krimpen
on #spatial anti-tumor immune responses in lymph node & next month's talk by
Vincent van Unen on disease-associated network analysis of the intestinal immune system!

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Apr 10

Come join us!

Alsya Affandi @jubillix.bsky.social · Apr 10

We’re looking for a Junior Postdoc to join our growing team at Amsterdam UMC, working on inhalable nanovaccines to activate lung immunity especially resident memory T cells (Trm) against cancer.

More info here👇
🔗 werkenbij.amsterdamumc.org/en/vacatures...
@mcbi-amsumc.bsky.social

Vacatures - Junior Postdoc Inhalable vaccine - Amsterdam UMC

Investigate whether local application in the lung can further enhance the efficacy of nanovaccines in generating lung-resident memory T cells.

werkenbij.amsterdamumc.org

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Reposted by Molecular Cell Biology and Immunology Lab

Alsya Affandi @jubillix.bsky.social · Apr 10

We’re looking for a Junior Postdoc to join our growing team at Amsterdam UMC, working on inhalable nanovaccines to activate lung immunity especially resident memory T cells (Trm) against cancer.

More info here👇
🔗 werkenbij.amsterdamumc.org/en/vacatures...
@mcbi-amsumc.bsky.social

Vacatures - Junior Postdoc Inhalable vaccine - Amsterdam UMC

Investigate whether local application in the lung can further enhance the efficacy of nanovaccines in generating lung-resident memory T cells.

werkenbij.amsterdamumc.org

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Mar 31

Our own Yvette van Kooyk will be presenting! See you there?

GlycoNet @glyconet.bsky.social · Mar 26

Thank you to @albertainnovates.bsky.social for partnering with #Glyco27, taking place May 25-30, 2025 in Edmonton!

Join us to explore the latest in glycoscience and biotechnology: www.glyco27.org/en/begin

Want to partner? glyco27.org/en/sponsor

@glycotime.bsky.social #glycoscience #glycomics

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Mar 26

For the next session of our Single Cell club we will host Rosalia Franco Fernandez @amsterdamumc.bsky.social to discuss CD8 responses in gastric cancer metastasis!

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Feb 20

Altogether, this model highlights the potential of lymphoma-on-chip models to study the role of lymph node stromal cells in cancer development and progression. Stay tuned for updates on this project!

Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Feb 20

(2) They also potentiated the ability of lymphoma cells to enhance lymphatic vessel permeability, although they did not affect permeability on their own.

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Feb 20

In addition, to survival this model hint at a role of FRCs in contributing to lymphoma cell metastasis in two different ways. (1) They promoted directional migration of lymphoma cells towards the lymphatic vessels.

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Feb 20

The addition of primary FRCs in the model improved the viability of the lymphoma cells, which was linked to increased production of interleukin-6, a known survival factor for hematological cancer cells.

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Feb 20

They describe the construction of a lymphatic vessel (red) surrounded by lymphoma cells (DLBCL, blue) and primary fibroblastic reticular cells (FRCs, green) in a hydrogel.

Immunofluorescence picture of the lymphoma-on-chip including staining of lymphatic vesell cells (red, CD31), primary fibroblasts (green, vimentin), and lymphoma cells (blue, "DLBCL").

3D-rendering of the lymphoma-on-chip including staining of lymphatic vesell cells (red, CD31), primary fibroblasts (green, vimentin), and lymphoma cells (blue).

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Feb 20

MCBI researchers led by Lotte de Winde developed a lymphome-on-chip model that include lymph node stromal cells (fibroblastic reticular cells), thereby offering a new model to study these cells in the development and progression of lymphoma!
tinyurl.com/2mads7kr

Lymphoma-on-chip model reveals that lymph node stromal cells promote diffuse large B-cell lymphoma survival and migration

Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive B-cell non-Hodgkin lymphoma, often developing resistance to current treatments. De…

tinyurl.com

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Dec 13

On the second day of the conference, Eleonora Nardini presented her PhD project aiming at understanding how peptide sialylation affects the adaptive response in hemophilia A. #glycotime

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Dec 11

In the mucosal immunology session Myrthe van Delft presented her research on the novel mice model to study the role of IgA in vivo. The project was performed together with the Lambrecht group @viblifesciences.bsky.social

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Dec 11

During the keynote, Elga de Vries presented her team’s work on the immune changes associated with the neurodegenerative diseases #MultipleSclerosis and dementia #Alzheimersdisease. Some of the presented results have been discussed there doi.org/10.7554/eLif... rdcu.be/d3b9Q

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Dec 11

Today is the beginning of the Dutch Society for Immunology Winterschool! Our department is well represented, starting with Sofía Ibáñez-Molero who presented past and future work on investigating the direct interaction between tumor cells and immune cells!

Sofía Ibánez-Molero in front of her title slide ‘Capturing tumor-immune cell interactions’.

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Dec 4

Hi! Could you add us to the starter pack too, please? :)

Reposted by Molecular Cell Biology and Immunology Lab

Johanna Joyce @johannajoyce.bsky.social · Nov 25

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
🧵 1/

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Dec 2

Hello Lucille! Could you add us to this starter pack, please?

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Dec 2

Hi Jon, could you add us if still possible? :)

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Dec 2

Hi! We’re late to the party but could you add us?

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Molecular Cell Biology and Immunology Lab @mcbi-amsumc.bsky.social · Dec 2

We’re late to the party but could you add us too?

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