Michael Doube
@mdoube.bsky.social
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mdoube.bsky.social
📢 New paper alert!

Type-I and -II collagens from bone and cartilage colocalize at the osteochondral cement line.

doi.org/10.1302/2046...

Khizar Hayat, @neilmarr.bsky.social and I show that collagens from bone and cartilage meet in a zone ~5µm thick, which might help to glue the tissues together.
mdoube.bsky.social
Girl yes, DEXA scans ✨
asbmr.bsky.social
🦴 Bone health is having a moment! #AmyPoehler dropped some osteoporosis awareness earlier this year.

In honor of #WorldOsteoporosisDay this month, we want to spotlight celebs who speak on bone health. 💬 Who’s your fave?

More in #LasCulturistas full ep: youtu.be/6Ab3vaatghk
mdoube.bsky.social
Robert I didn't mean you when I referred to AI slop, ofc. 😂 I see a lot of dumb images illustrating formulaic "country discovered thing!" badly framed attention-seeking posts.
mdoube.bsky.social
Surely the ND (no derivative works) bit of a CC-BY-ND licence precludes incorporating material from a paper into a model?
andybrockman.bsky.social
Everybody makes money out of academic authors except the authors...News.

Wiley is the latest academic publisher to reach a multi-million deal to allow access to its content to AI developers, with no opt out, let alone payment, for the authors who created that content.
Wiley set to earn $44m from AI rights deals, confirms “no opt-out" for authors
The US publisher is the latest to capitalise on deals to give tech firms access to its authors’ content to train their Large Language Models (LLMs).
www.thebookseller.com
Reposted by Michael Doube
andybrockman.bsky.social
Everybody makes money out of academic authors except the authors...News.

Wiley is the latest academic publisher to reach a multi-million deal to allow access to its content to AI developers, with no opt out, let alone payment, for the authors who created that content.
Wiley set to earn $44m from AI rights deals, confirms “no opt-out" for authors
The US publisher is the latest to capitalise on deals to give tech firms access to its authors’ content to train their Large Language Models (LLMs).
www.thebookseller.com
mdoube.bsky.social
I concur. Stylistically it's a bit twee ("I was honoured to have done this thing...") but quite a lot going on there from the professional sphere. Algorithm does tend to shove bad science reporting in your face and there is a lot of AI slop posting.
mdoube.bsky.social
It's a great leveller. Everyone turns up for the ritual, driving their Aston Martin or riding their bike.
mdoube.bsky.social
... aerosols, motor oil, vegetable oil, nespresso pods, PET, clothes, building rubble... I think that's it.
mdoube.bsky.social
Compost, wood, corks, metal lids, clear glass, green glass, brown glass, furniture, iron, paper, cardboard, plastic, chemicals, alkaline batteries, lithium batteries, aluminium cans, aluminium foil, tetrapaks, milk bottles, medicines, radiographs, electronics, toys, cds, dvds, books, unrecyclables,
mdoube.bsky.social
Good bin run today! Scored a box set of the best Star Wars movies.

Waste management is a big deal in 🇨🇭. Other places have a dump or a tip but it's classy here, we have a déchetterie with maybe 20 categories to sort into. Will try to list them all in a reply...
Box set of the only good Star Wars movies, the middle three from the late seventies.
mdoube.bsky.social
You can fake an image no matter the technology. Even an electronic "this is an original image from this device" certificate trail (using hashes or whatever) can be spoofed, just by staging the subject. Better to work on the incentives that drive people to fraud, in my view.
Reposted by Michael Doube
kwolbachia.bsky.social
I’m happy to share some plugins I’ve been developping this summer: "Channels and Contrast" and LUTs Manager!
I can’t find new bugs and ideas by now so I need your help to please test them in your machines and report bugs, feedbacks and ideas! forum.image.sc/t/looking-fo...
mdoube.bsky.social
Really important perspective for funders (and participants) in risky exploratory endeavours.
mdoube.bsky.social
Long, slender trabeculae pass across the marrow space. Trabeculae help resist weightbearing loads. But these ones don't appear to be in a good configuration to do that, unlike the spongy trabeculae nearby.

Maybe they're holding adipose tissue in place, preventing it from wobbling during locomotion?
mdoube.bsky.social
The stripe of dense bone running from top right to lower left is the growth plate scar, separating the main part of the bone from the epiphysis, the knobbly joint condyle. It's formed when the cartilagenous growth plate stops expanding and is replaced by bone.
mdoube.bsky.social
Top left is the cortical ('dense') bone shell. Looks solid but it's porous, filled with millions of osteocytes and capillaries serving them. Bottom right is spongy (trabecular, cancellous) bone, thought to help spread joint loads.
mdoube.bsky.social
The leftovers from last week's bœuf bourguignon. This is a 'marrow bone' after boiling out the adipose tissue for gravy and washing in lots of warm tap water, household detergents and a little chlorine bleach. Cortex & (glorious) trabeculae, growth plate 'scar', marrow cavity visible.
Reposted by Michael Doube
bethcimini.bsky.social
Halfway to I2K is BACK, friends of all kinds! Last year, 650 people attended 30+ TOTALLY FREE image analysis workshops of all kinds, across many timezones.

If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.
bioimagingna.bsky.social
#HappyFluorescenceFriday!

#microscopycommunity- want to learn open source image analysis or share your knowledge to help others? We’ve got a FREE virtual workshop Nov 17-19! Now accepting workshop session applications!

Learn more & sign up: buff.ly/esGIotD
mdoube.bsky.social
Well - it was earlier than that but not much. Alan Boyde at UCL was using a Petran & Hadravsky spinning disc confocal from Czechoslovakia (apparently he drove it over himself and had to be bailed out at the border by friends and colleagues over an enormous import duty bill). doi.org/10.1126/scie...
Stereoscopic Images in Confocal (Tandem Scanning) Microscopy
Stereoscopic pair images with parallel projection geometry are obtained by through-focusing along two inclined axes while recording two (summed and stacked) images with a microscope with a very shallo...
doi.org
mdoube.bsky.social
Spinning disc confocal was already in use in London at UCL after Alan Boyde imported one from behind the iron curtain, hand made by Petran and Hadravsky in Czechoslovakia. See this 1985 article in @science.org doi.org/10.1126/scie...

(it was still going 20 years later when I did my PhD with Alan)
Stereoscopic Images in Confocal (Tandem Scanning) Microscopy
Stereoscopic pair images with parallel projection geometry are obtained by through-focusing along two inclined axes while recording two (summed and stacked) images with a microscope with a very shallo...
doi.org
Reposted by Michael Doube
cecibaldoni.bsky.social
PhD Alert! 😍 Our lab is hiring a PhD student to study how shrews shrink in winter and grow in spring. Yes, you read that right!
tinyurl.com/shrinkingshr...
Join us at the @mpi-animalbehav.bsky.social, study a super cool animal, and join the @imprs-qbee.bsky.social community!

DM me for questions!
Seasonal size change and aging in shrews
imprs-qbee.mpg.de