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From signals to stories: Dr. Mariya Mardamshina on decoding cells through spatial proteomic pipelines

Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Sep 2

IonOpticks is proud to be at #NordicMSP2025 in Odense, celebrating 50 years of MS at SDU. Meet Erik, Britta & Joris at our stand to explore how IonOpticks chromatography can level up your LC-MS workflows and push your research further with sharper, deeper insights.

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Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Sep 4

Moe Haines is transforming decades-old tissue samples into rich sources of medical knowledge. The researcher at the
@broadinstitute.org's Proteomics Platform shared how reliable chromatography has accelerated his breakthroughs in cancer and rare disease research.

Learn more: bit.ly/3JMl0d4

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Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Sep 9

@mari-mardamshin.bsky.social has seen firsthand how the loss of pancreatic function can affect someone’s life.

“Knowing that our work might one day contribute to restoring this complex organ’s function brings an added layer of meaning to what we do in the lab each day.”

Learn more: bit.ly/46ddJdS

Mariya Mardamshina M.D.

Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · 29d

Dr. Tim Veth, a postdoc working with @nmriley.bsky.social at the University of Washington, is tackling glycoproteomics. When we spoke about navigating the complexity of analysing thousands of glycoproteoforms, he shared how reliable chromatography supports his research.

Learn more: bit.ly/4nrMzad

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Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · 28d

Join IonOpticks in Montréal next week for #MSACL2025. Zac and Erik will be on the ground at the Hôtel Bonaventure Montréal, ready to chat with you about all things chromatography. Meet them at the IonOpticks booth to see how how our new product ranges can help you elevate your LC/MS workflows.

Thousands of forms, one protein: how Tim Veth is deciphering the complex language of Glycans

Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · 23d

Our birthday, your gift: Today, we celebrate eight years of peak chromatography by inviting new users to access our industry-leading columns at rates we've never offered before.

Tell us about your setup and claim our biggest, most significant new-user discount. Ever.

Claim now: bit.ly/4nxwpwa

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Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jul 23

"I invite all researchers to enter the glycoproteomics field and join the battle.”

With the complexity of glycoproteomics and how little we still know, Tim Veth puts out a rallying cry to speed up development in this promising field.

Learn more about Tim & read our discussion: bit.ly/3IXpo8B

Tim Veth, a postdoctoral researcher working with Prof. Nicholas M.

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Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jul 16

We were chatting with Dr. Mike Lanz, proteomics researcher at Stanford and the Chan Zuckerberg Biohub, about his research into proteome composition and how it reflects a cell’s size and growth rate.

He also shared his experience with Aurora Series columns,

Learn more about Mike: bit.ly/3BXQRUV

Increasing mass spectrometry throughput using time-encoded sample multiplexing - IonOpticks

Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jul 13

New "timePlex" method multiplexes LC-MS proteomics samples in time domain. Using IonOpticks columns + UltiMate 3000 + Orbitrap Exploris, achieved 27-fold multiplexing & >500 samples/day. 5.6x more protein IDs per run vs standard methods.

Learn more: bit.ly/3GssfWh

#Proteomics #LCMS

This method for increasing mass spectrometry throughput by Derks et al. used a 25 cm x 75 um IonOpticks Aurora Ultimate 25x75 UHPLC column.

An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day - IonOpticks

Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jul 9

It’s been a great start to the BSPR Annual Meeting 2025 in Liverpool. If you haven’t already, stop by the IonOpticks booth today, where Erik would be delighted to chat about how our new releases can elevate your proteomics workflows.

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Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jul 8

It was great to work with omicSolution, our distributor in China, during the First Single Cell Proteomics Academic Conference in Hangzhou. Thanks to the π-HuB Project, Zhejiang University’s Department of Chemistry, & the Hangzhou International Science and Technology Innovation Center for organising.

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Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jul 7

High-throughput spatial proteomics workflow: Klingeberg et al. develop optimised workflow using Evosep One with different Aurora Series columns coupled to a timsUltra AIP. Quantified 3,000+ proteins from 0.04 nL tissue volumes, achieving 100+ samples daily - a 3x throughput increase.

bit.ly/3GlNQ2J

This ultrasensitive spatial tissue proteomics workflow by Klingeberg et al. used a 5 cm x 75 um IonOpticks Aurora Rapid 5x75 CSI UHPLC column

From doubt to discovery: charting new territories in epigenetics with Dr. Bercin Cenik

Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jul 2

Great to attend @sciex.bsky.social's #ZenoTOF 8600 and 7500+ Roadshow at Bio21 today! Impressive sensitivity & speed with our Aurora XS columns. Tim Heymann's data: 12,000+ proteins from 200ng sample. Excited for August launch & continued @SCIEX partnership! #MassSpec #Proteomics

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Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jul 1

"At that point, we realised we were onto something real."

Dr. Bercin Cenik had to overcome real doubt to develop TurboCas, a genetic tool that overcomes fundamental barriers in epigenetics research. Now, the method is being adopted by labs around the world.

Learn more: bit.ly/3TkEQOb

Bercin Cenik, a Research Assistant Professor working with Dr. Ali Shilatifard at Northwestern University's Department of Biochemistry and Molecular Genetics, is developing technologies that are tackli...

Improving proteomic dynamic range with Multiple Accumulation Precursor Mass Spectrometry (MAP-MS) - IonOpticks

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Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jul 1

We had a wonderful experience exhibiting in Japan for the first time at #AOMSC2025 in Okinawa. It was great to spend time with our distributor in the region, AMR Inc. Thanks to the organisers for bringing us together and for an outstanding program that showcased the latest innovations in the region.

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Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jun 29

MAP-MS overcomes dynamic range limitations in Orbitrap instruments.

Using an Exploris 480 with an EASY-nLC 1200 and Aurora Ultimate XT column, Phlairaharn et al. achieved a 9% increase in protein IDs for DDA and a 4% improvement for DIA, while halving quantitative variation.

bit.ly/4dYRZWF

This study into improving proteomic dynamic range by Phlairaharn et al. used a 25 cm x 75 um IonOpticks Aurora Ultimate XT 15x75 UHPLC column

Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jun 24

Every enhancement in Gen 4 Aurora Series® comes from direct collaboration with researchers.

"We work closely with researchers to understand their challenges and ensure our products address them head-on,” explains IonOpticks Chief Product Officer Dr. Jarrod Sandow.

Discover Gen 4: bit.ly/43OX6VQ

Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jun 24

Au revoir, Saint-Malo. It’s been an absolute pleasure getting to connect with enthusiastic proteomics researchers in front of the beachy backdrop at #EuPA2025.

Thank you to the European Proteomics Association for bringing us all together for a look at the state and future directions of proteomics.

Multiplexed Deep Visual Proteomics Unveils Spatial Heterogeneity and Rare Endocrine States in Human Adult Pancreatic Islets - IonOpticks

Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jun 22

Researchers from the Lundberg lab have developed mxDVP, integrating high-plex microscopy with ultra-sensitive MS to explore pancreatic islet heterogeneity at unprecedented resolution.

Evosep One coupled to an Orbitrap Astral or timsTOF SCP, Aurora Elite columns on both instruments

bit.ly/3FGmeoG

This human adult pancreatic islets study by Mardamshina et al. used a 15 cm x 75 um IonOpticks Aurora Elite XT 15x75 UHPLC column.

Reposted by Michael Sinden

IonOpticks @ionopticks.bsky.social · Jun 20

A powerful demonstration of just what the Orbitrap Astral Zoom is capable of in Thermo's poster at #EuPA2025.

From 3,700 protein group IDs at 120 SPD (50 pg) to 6,800 protein group IDs at 50 SPD (250 pg), the combo of Orbitrap Astral Zoom + Aurora Series is already demonstrating impressive results.