MedComm
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MedComm
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MedComm is a peer‐reviewed, online OA journal that publishes the pioneer works of medicine on the basis of novelty, timeliness and significance on human health.
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MedComm @medcomm.bsky.social · 13d
🎉Congratulations！

In the recently released JCR Impact Factor 2024, MedComm maintained an IF of 10.7, placing it in the Q1 category for Medicine, Research & Experimental, ranking 14/195. Welcome to submit your next manuscripts to MedComm!

#JCR2025 #TrustedJournals #ImpactFactor
medcomm.bsky.social
#Review in #MedComm
Obesity Paradox in Cancer: A Complex Interplay Between Risk and Therapeutic Outcomes doi.org/10.1002/mco2...

#BodyMassIndex #ICIs #MetabolicDysregulation #ObesityParadox #TME
Obesity Paradox in Cancer: A Complex Interplay Between Risk and Therapeutic Outcomes
This review summarizes how obesity-driven metabolic and immune alterations contribute to both cancer development and the paradoxical improvement of immunotherapy outcomes.
doi.org
November 20, 2025 at 9:40 AM
medcomm.bsky.social
#Article in #MedComm
CD36 Inhibits Triple-Negative Breast Cancer Progression by Transcriptionally Upregulating Caveolin-1 and Promoting Lipid-Reactive Oxygen Species-Related Ferroptosis doi.org/10.1002/mco2...

#caveolin_1 #CD36 #ferroptosis #TNBC #CAV1
CD36 Inhibits Triple‐Negative Breast Cancer Progression by Transcriptionally Upregulating Caveolin‐1 and Promoting Lipid‐Reactive Oxygen Species‐Related Ferroptosis
CD36 is identified as a key suppressor in triple-negative breast cancer (TNBC). It inhibits tumor metastasis by promoting ferroptosis via the CD36–CAV1–lipid peroxidation axis. Multiomics and metasta...
doi.org
November 20, 2025 at 9:37 AM
medcomm.bsky.social
#Article in #MedComm
Unleashing the Potential: First-in-Human Evaluation of Automatic Robotic-Assisted Endovascular Aortic Repair for Standardized Therapies doi.org/10.1002/mco2...

#automatic #EndovascularAorticRepair #SurgicalAlgorithm #SurgicalRobot #EVAR
Unleashing the Potential: First‐in‐Human Evaluation of Automatic Robotic‐Assisted Endovascular Aortic Repair for Standardized Therapies
EVAR was deconstructed into surgical algorithms consisting of various parameters, which were obtained using image processing software and then inputted into the surgical robot. The endovascular surgi...
doi.org
November 20, 2025 at 9:33 AM
medcomm.bsky.social
#Letter in #MedComm
#Metabolic #Reprogramming for Body Adaptation and Inflammatory Control in Eccentric Damaging Exercise: Comprehensive Molecular Insights From Repeated Downhill Running doi.org/10.1002/mco2...

#TCA #CK #CreatineKinase #myoglobin #HRMS
November 20, 2025 at 9:29 AM
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#Review in #MedComm
Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions doi.org/10.1002/mco2...

#AutoimmunePathologies #cancer #phosphorylation #PKC #TherapeuticTarget
November 20, 2025 at 9:26 AM
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#Article in #MedComm
Incidence, Risk Factors, and Epidemiological Trends of Head and Neck Cancer: A Global Analysis doi.org/10.1002/mco2...

#distribution #HNC #RiskFactor #TemporalTrend
Incidence, Risk Factors, and Epidemiological Trends of Head and Neck Cancer: A Global Analysis
Global incidence of head and neck cancer by regions in 2022.
doi.org
November 20, 2025 at 9:22 AM
medcomm.bsky.social
#Review in #MedComm_Oncology
Targeting Metabolic Reprogramming in Tumor: From Mechanisms to Precision Immunotherapies doi.org/10.1002/mog2...

#ImmuneResponse #immunotherapy #MetabolicReprogramming #TME
November 20, 2025 at 9:16 AM
medcomm.bsky.social
#Letter in @MedComm_MC
Size Matters: Small Circulating Tumor Cells Indicate Worse Therapy Response in Breast Cancer doi.org/10.1002/mco2...

#CellMorphology #CirculatingTumorCells #FlowCytometry #TherapyResponse
November 14, 2025 at 3:45 AM
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#Article in #MedComm
Targeting the Liquid–Liquid Separation Region of c-Maf for Treating Chromosomal Translocations in Multiple Myeloma doi.org/10.1002/mco2...

#BenzoylBenzoicAcid #cMaf #ChromosomalTranslocation #LLPS #MultipleMyeloma #IDRs #BBA
Targeting the Liquid–Liquid Separation Region of c‐Maf for Treating Chromosomal Translocations in Multiple Myeloma
Targeting the liquid-liquid separation region of c-Maf for treating pathogenic chromosomal translocations in multiple myeloma. c-Maf promotes cell proliferation by forming liquid–liquid phase separat....
doi.org
November 14, 2025 at 3:39 AM
medcomm.bsky.social
#Review in #MedComm
The Gut‒Liver Axis in Liver Disease: Molecular Mechanisms and Therapeutic Targets doi.org/10.1002/mco2...

#GutLiverAxis #dysbiosis #IntestinalBarrierDysfunction #LiverDisease #pathogenesis
The Gut‒Liver Axis in Liver Disease: Molecular Mechanisms and Therapeutic Targets
The global burden of liver disease is increasing, and gut-liver axis dysregulation is a key driver. This article explains its mechanisms in various liver diseases and explores targeted therapeutic st....
doi.org
November 14, 2025 at 3:35 AM
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#Article in #MedComm

Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis doi.org/10.1002/mco2...

#ATP #mitochondria #MycobacteriumTuberculosis #Mtb #StressGranule #tuberculosis
Host Translational Control by Stress Granules Promotes Mycobacterium tuberculosis Pathogenesis
During Mycobacterium tuberculosis infection, stress granules (SGs) formed in macrophages sequester key signaling and metabolic regulators such as mTORC1 components (mTOR, Raptor) and mitochondrial co...
doi.org
November 14, 2025 at 3:05 AM
medcomm.bsky.social
#Article in #MedComm
#Exosomal Long Interspersed Nuclear Element-1 Analytes Discriminate Histologic Subtypes, Sex, and Clinicopathological Characteristics of Patients with Non-Small Cell Lung #Cancer doi.org/10.1002/mco2..., studied by a team from @CenterTexas

#biomarker
Exosomal Long Interspersed Nuclear Element‐1 Analytes Discriminate Histologic Subtypes, Sex, and Clinicopathological Characteristics of Patients with Non‐Small Cell Lung Cancer
Exosomal long interspersed nuclear element-1 (LINE-1) analytes exhibit distinct expression profiles across histologic subtypes of non-small cell lung cancer (NSCLC) and demonstrate significant associ...
doi.org
November 14, 2025 at 2:53 AM
medcomm.bsky.social
#Article in #MedComm
Quantitative Computed Tomographic Clusters in C-BIOPRED Asthma #Cohort: Association with Sputum Proteomics doi.org/10.1002/mco2...

#AirflowObstruction #asthma #AirwayRemodeling #qCT #proteomics
Quantitative Computed Tomographic Clusters in C‐BIOPRED Asthma Cohort: Association with Sputum Proteomics
Using quantitative computed tomography (qCT) clustering in the C-BIOPRED asthma cohort of 239 patients, four distinct phenotypes were identified based on airway dimensions, lung volumes, and densitom...
doi.org
November 14, 2025 at 2:36 AM
medcomm.bsky.social
#Review in #MedComm
Fusobacterium nucleatum in Health and Disease doi.org/10.1002/mco2...

#FusobacteriumNucleatum #health #inflammation #malignancy #microbiota
Fusobacterium nucleatum in Health and Disease
Fusobacterium nucleatum (Fn), an oral commensal and opportunistic pathogen, primarily colonizes the oral cavity. It contributes to multiple nonmalignant diseases and cancers—especially colorectal can...
doi.org
November 14, 2025 at 2:31 AM
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#Article in #MedComm
Aberrant Expression of A Disintegrin and Metalloproteinase With Thrombospondin Motifs 13 (ADAMTS13) in Pancreatic Cancer Leads to Dichotomic Functions doi.org/10.1002/mco2...

#ADAMTS13 #adipokine #pancreas #PDAC #PeripancreaticAdipose #vascularization
Aberrant Expression of A Disintegrin and Metalloproteinase With Thrombospondin Motifs 13 (ADAMTS13) in Pancreatic Cancer Leads to Dichotomic Functions
Allmang et al. demonstrated that ADAMTS13 is overexpressed in PDAC, associated with prolonged survival and reduced vascular density. Knockout of ADAMTS13 in PDAC cells led to a decrease in migration ...
doi.org
November 14, 2025 at 2:28 AM
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#Review in #MedComm
Trained Immunity in Health and Disease doi.org/10.1002/mco2...

#EpigeneticInheritance #Immunotherapy #ImmuneCell #MetabolicReprogramming #TrainedImmunity
Trained Immunity in Health and Disease
Growth and timescale of medical publications on trained immunity and its related health and disease. This figure illustrates the number of published papers over time, from 2000 to 2025 (by August 14,...
doi.org
November 14, 2025 at 2:09 AM
medcomm.bsky.social
#Article in #MedComm

First-Line Third-Generation #EGFR Tyrosine Kinase Inhibitor Monotherapy for Advanced EGFR-Mutated Non-Small Cell Lung Cancer: A Systematic Review and Network Meta-Analysis doi.org/10.1002/mco2...

#MetaAnalysis #NSCLC #TKI #FirstLine #TRAE #Monotherapy
First‐Line Third‐Generation EGFR Tyrosine Kinase Inhibitor Monotherapy for Advanced EGFR‐Mutated Non‐Small Cell Lung Cancer: A Systematic Review and Network Meta‐Analysis
Third-generation EGFR-TKIs are the current first-line standard for advanced EGFR-mutated NSCLC. While all improve PFS versus first-generation TKIs, no significant PFS or ORR differences exist among t...
doi.org
November 14, 2025 at 2:04 AM
medcomm.bsky.social
#Review in #MedComm_Biomatrials_and_Applications
Modular Nanosensing Platforms for Tuberculosis and Beyond: Engineering Biomaterials Toward Cross-Pathogen Diagnostic Universality doi.org/10.1002/mba2...

#cross_pathogen #diagnostic #modular #nanosensing #platforms #nanobiosensor
November 14, 2025 at 1:50 AM
medcomm.bsky.social
🎉Congratulations！

In the recently released JCR Impact Factor 2024, MedComm maintained an IF of 10.7, placing it in the Q1 category for Medicine, Research & Experimental, ranking 14/195. Welcome to submit your next manuscripts to MedComm!

#JCR2025 #TrustedJournals #ImpactFactor
November 7, 2025 at 8:36 AM
medcomm.bsky.social
#Article in #MedComm
Neurofilament Light Chains in Serum Predict Post—Transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy doi.org/10.1002/mco2...

#AxonalDamage #biomarker #CognitiveDysfunction #TIPS #GFAP
Neurofilament Light Chains in Serum Predict Post—Transjugular Intrahepatic Portosystemic Shunt Hepatic Encephalopathy
Hepatic encephalopathy (HE) after transjugular intrahepatic portosystemic shunt (TIPS) insertion constitutes a frequent and severe complication, however, biomarkers are currently scarce. The results ...
doi.org
November 7, 2025 at 8:23 AM
medcomm.bsky.social
#Article in #MedComm
Chidamide (a Histone Deacetylase Inhibitor) Plus Abiraterone in Metastatic Castration-Resistant Prostate Cancer (mCRPC): A Phase Ib Trial doi.org/10.1002/mco2...
#Clinicaltrial #EpigeneticRegulation #HistoneDeacetylase #mCRPC
Chidamide (a Histone Deacetylase Inhibitor) Plus Abiraterone in Metastatic Castration‐Resistant Prostate Cancer (mCRPC): A Phase Ib Trial
Metastatic castration-resistant prostate cancer (mCRPC) remains challenging. This Phase Ib trial tested chidamide, a selective HDAC inhibitor, plus abiraterone in 18 patients. The regimen was well to...
doi.org
November 7, 2025 at 8:21 AM
medcomm.bsky.social
#Review in #MedComm
Artificial Intelligence for the Diagnosis and Management of Cancers: Potentials and Challenges doi.org/10.1002/mco2...

#ArtificialIntelligence #AI #cancer #CancerDiagnosis #PrognosisPrediction #personalized #therapy
Artificial Intelligence for the Diagnosis and Management of Cancers: Potentials and Challenges
Artificial intelligence (AI) is a rising star in the field of medicine, avoiding misdiagnosis by human negligence, reducing the workload of doctors, and aiding clinicians in decision-making. AI can i...
doi.org
November 7, 2025 at 8:20 AM
medcomm.bsky.social
#Review in #MedComm @wiley.com
Dendritic Cells: Origin, Classification, Development, Biological Functions, and Therapeutic Potential doi.org/10.1002/mco2...

#BiologicalFunction #Classification #development #DendriticCell #Origin #TherapeuticPotential
Dendritic Cells: Origin, Classification, Development, Biological Functions, and Therapeutic Potential
This review systematically summarizes dendritic cells (DCs) originating from hematopoietic stem cells, their major subsets (cDC1s, cDC2s, pDCs, moDCs, LCs) and core functions (antigen capture/present...
doi.org
November 7, 2025 at 8:20 AM
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#Article in #MedComm
SARS-CoV-2 Spike Protein as a Target of the COVID-19 Vaccine Disrupts Insulin Signaling in Type 2 Diabetes doi.org/10.1002/mco2...

#COVID_19 #diabetes #InsulinSensitivity #SARS_CoV_2
#Vaccine #Protein #Target
SARS‐CoV‐2 Spike Protein as a Target of the COVID‐19 Vaccine Disrupts Insulin Signaling in Type 2 Diabetes
SARS Cov-2 spike protein disrupts insulin signaling in type 2 diabetes as a target of the COVID-19 vaccine in subject with type 2 diabetes (T2D), while metformin improved the insulin signaling variat...
doi.org
November 7, 2025 at 8:19 AM
medcomm.bsky.social
#Article in #MedComm @wiley.com
Synthesized Depside Molecules Suppress the Progression of Colorectal Cancer by Binding VDAC1/PHB/MMP9 Being at the Crossroads of Stemness, Motility, Apoptosis, and Metabolism doi.org/10.1002/mco2...

#MMP #prohibitin1 #VDAC1 #probe #BindingIdentification
Synthesized Depside Molecules Suppress the Progression of Colorectal Cancer by Binding VDAC1/PHB/MMP9 Being at the Crossroads of Stemness, Motility, Apoptosis, and Metabolism
This study suggests that newly synthesized depside compounds suppress the progression of colorectal cancer by directly targeting VDAC1/PHB/MMP9. Especially, SB4 demonstrated significant bioavailabili...
doi.org
November 7, 2025 at 8:19 AM