Mel Eckersley-Maslin
@meleckmas.bsky.social
Lab head in stem cell and cancer epigenetics at PeterMac, UniMelb 🇦🇺🧬
Scientist, mum, dreamer
She/her. Views are my own
www.eckmaslab.com
Scientist, mum, dreamer
She/her. Views are my own
www.eckmaslab.com
Great first day of stem cell science on the beach at #ASSCR2025! Here is our @asscr.bsky.social president opening the conference. Highlights include keynote from @josh-brickman.bsky.social and presentation of @ausstemcell.bsky.social 2025 Metcalf awards. Congratulations to the worthy recipients!
November 10, 2025 at 8:54 AM
Great first day of stem cell science on the beach at #ASSCR2025! Here is our @asscr.bsky.social president opening the conference. Highlights include keynote from @josh-brickman.bsky.social and presentation of @ausstemcell.bsky.social 2025 Metcalf awards. Congratulations to the worthy recipients!
Melbourne Epigenetics club on today! Two fabulous speakers followed by a catered networking reception. If you’re in Melbourne please drop by!
October 6, 2025 at 9:43 PM
Melbourne Epigenetics club on today! Two fabulous speakers followed by a catered networking reception. If you’re in Melbourne please drop by!
Constantly amazed by all the extra hidden talents by those in the lab! German blueberry cake with caramel baked by the talented Clare to celebrate a lab-mate’s birthday
September 18, 2025 at 8:11 PM
Constantly amazed by all the extra hidden talents by those in the lab! German blueberry cake with caramel baked by the talented Clare to celebrate a lab-mate’s birthday
If you love #chromatin and are in Melbourne on 18th June, join us for the next Melbourne Epigenetics Club!
Featuring Tim Johanson, Conny Bonifer and Brent Thomson @dtgenomics.bsky.social, followed by networking reception
Free event but registration essential www.eventbrite.com.au/e/5th-melbou...
Featuring Tim Johanson, Conny Bonifer and Brent Thomson @dtgenomics.bsky.social, followed by networking reception
Free event but registration essential www.eventbrite.com.au/e/5th-melbou...
May 22, 2025 at 12:56 PM
If you love #chromatin and are in Melbourne on 18th June, join us for the next Melbourne Epigenetics Club!
Featuring Tim Johanson, Conny Bonifer and Brent Thomson @dtgenomics.bsky.social, followed by networking reception
Free event but registration essential www.eventbrite.com.au/e/5th-melbou...
Featuring Tim Johanson, Conny Bonifer and Brent Thomson @dtgenomics.bsky.social, followed by networking reception
Free event but registration essential www.eventbrite.com.au/e/5th-melbou...
Stunning location for next stop of my Europe tour- the GRC cancer genetics and epigenetics conference. Thoroughly enjoying all the science presentations so far!
May 19, 2025 at 12:49 PM
Stunning location for next stop of my Europe tour- the GRC cancer genetics and epigenetics conference. Thoroughly enjoying all the science presentations so far!
One of my favourite parts of this Europe trip has been catching up with former students @nchoy.bsky.social (now intern with @robertife.bsky.social) and @elisakre.bsky.social (now pdoc with @priscaliberali.bsky.social). It’s so great to see you both doing so well!
May 18, 2025 at 10:48 AM
One of my favourite parts of this Europe trip has been catching up with former students @nchoy.bsky.social (now intern with @robertife.bsky.social) and @elisakre.bsky.social (now pdoc with @priscaliberali.bsky.social). It’s so great to see you both doing so well!
First time back in Europe since establishing the lab in Australia in 2021. First stop #EMBLChromatin!
Stop by poster 200 or find me at coffee if you want to discuss Janith’s recent work on what happens when embryonic chromatin regulators are hijacked in cancers
Stop by poster 200 or find me at coffee if you want to discuss Janith’s recent work on what happens when embryonic chromatin regulators are hijacked in cancers
May 13, 2025 at 11:03 AM
First time back in Europe since establishing the lab in Australia in 2021. First stop #EMBLChromatin!
Stop by poster 200 or find me at coffee if you want to discuss Janith’s recent work on what happens when embryonic chromatin regulators are hijacked in cancers
Stop by poster 200 or find me at coffee if you want to discuss Janith’s recent work on what happens when embryonic chromatin regulators are hijacked in cancers
This raised a key Q: How can you have PRC1-deposited H2AK119Ub without PRC2-deposited H3K27me3?
At many of K4-K119Ub sites, PRC2 is present, but high levels of H3K27ac is likely preventing its catalytic activity. If we forcefully remove H3K27ac, now H3K27me3 accumulates, silencing the genes. (5/6)
At many of K4-K119Ub sites, PRC2 is present, but high levels of H3K27ac is likely preventing its catalytic activity. If we forcefully remove H3K27ac, now H3K27me3 accumulates, silencing the genes. (5/6)
April 28, 2025 at 11:07 AM
This raised a key Q: How can you have PRC1-deposited H2AK119Ub without PRC2-deposited H3K27me3?
At many of K4-K119Ub sites, PRC2 is present, but high levels of H3K27ac is likely preventing its catalytic activity. If we forcefully remove H3K27ac, now H3K27me3 accumulates, silencing the genes. (5/6)
At many of K4-K119Ub sites, PRC2 is present, but high levels of H3K27ac is likely preventing its catalytic activity. If we forcefully remove H3K27ac, now H3K27me3 accumulates, silencing the genes. (5/6)
Many of these DPPA2/4 bound promoters were poised with H3K4me3 and H2AK119Ub, but not H3K27me3. We validated these K4-K199 regions by reChIP, and found DPPA2/4 depletion leads to reduced K119Ub at these sites (4/6)
April 28, 2025 at 11:07 AM
Many of these DPPA2/4 bound promoters were poised with H3K4me3 and H2AK119Ub, but not H3K27me3. We validated these K4-K199 regions by reChIP, and found DPPA2/4 depletion leads to reduced K119Ub at these sites (4/6)
Proteomics and biochemistry confirmed these proteins physically interact to bind nucleosomes. Interestingly DPPA2 seems to require DPPA4 for its stability (but not vice versa).
We mapped their genome binding sites using both CUT&Run and ChIP - DPPA2/4 bind together at CpG rich promoters (3/6)
We mapped their genome binding sites using both CUT&Run and ChIP - DPPA2/4 bind together at CpG rich promoters (3/6)
April 28, 2025 at 11:07 AM
Proteomics and biochemistry confirmed these proteins physically interact to bind nucleosomes. Interestingly DPPA2 seems to require DPPA4 for its stability (but not vice versa).
We mapped their genome binding sites using both CUT&Run and ChIP - DPPA2/4 bind together at CpG rich promoters (3/6)
We mapped their genome binding sites using both CUT&Run and ChIP - DPPA2/4 bind together at CpG rich promoters (3/6)
Our pan-cancer analysis showed co-expression of DPPA2/4 was associated with significantly worse outcomes in lung squamous cell carcinoma, adenocarcinoma and low grade gliomas.
In NSCLCs, it was also associated with dedifferentiated transcriptional states (2/6)
In NSCLCs, it was also associated with dedifferentiated transcriptional states (2/6)
April 28, 2025 at 11:07 AM
Our pan-cancer analysis showed co-expression of DPPA2/4 was associated with significantly worse outcomes in lung squamous cell carcinoma, adenocarcinoma and low grade gliomas.
In NSCLCs, it was also associated with dedifferentiated transcriptional states (2/6)
In NSCLCs, it was also associated with dedifferentiated transcriptional states (2/6)
Delighted to share the latest preprint from the lab led by Janith Seneviratne
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
April 28, 2025 at 11:07 AM
Delighted to share the latest preprint from the lab led by Janith Seneviratne
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
We reveal novel roles for #embryonic regulators DPPA2/4 in facilitating a H2AK119Ub primed #chromatin state when aberrantly up-regulated in non-small cell lung #cancers 🧬🔬 (1/6)
www.biorxiv.org/content/10.1...
At my 4 year old son’s kinder graduation today they were asked what they wanted to be when they grow up. From the 24 kids, 2 wanted to be scientists - both girls! #FutureWomenInStem 🧪👩🔬🔬
December 19, 2024 at 8:01 AM
At my 4 year old son’s kinder graduation today they were asked what they wanted to be when they grow up. From the 24 kids, 2 wanted to be scientists - both girls! #FutureWomenInStem 🧪👩🔬🔬
Happy holidays from the EckMasLab! We have some exciting findings coming together that we hope to share with you all in 2025 🧬🧪🎄
December 19, 2024 at 12:19 AM
Happy holidays from the EckMasLab! We have some exciting findings coming together that we hope to share with you all in 2025 🧬🧪🎄
Lab minigolf party to farewell Natalie after a wonderful 2 years as a summer student, honours student and RA. Seems only fitting she won the tournament! (I wont disclose who came last…)
The future is bright for you Natalie, we’ll miss you but wish you all the best with @robertife.bsky.social! 🧪🧬👩🔬
The future is bright for you Natalie, we’ll miss you but wish you all the best with @robertife.bsky.social! 🧪🧬👩🔬
December 6, 2024 at 4:38 AM
Lab minigolf party to farewell Natalie after a wonderful 2 years as a summer student, honours student and RA. Seems only fitting she won the tournament! (I wont disclose who came last…)
The future is bright for you Natalie, we’ll miss you but wish you all the best with @robertife.bsky.social! 🧪🧬👩🔬
The future is bright for you Natalie, we’ll miss you but wish you all the best with @robertife.bsky.social! 🧪🧬👩🔬
Fantastic third instalment of the Melbourne Epigenetics Club featuring talks by Lee Wong and Hamish King, and a networking reception
If you’re in Melbourne and interested in #chromatin #epigenetics or #GeneRegulation and interested in attending, visit www.eckmaslab.com/melbourne-ep... 🧪🧬
If you’re in Melbourne and interested in #chromatin #epigenetics or #GeneRegulation and interested in attending, visit www.eckmaslab.com/melbourne-ep... 🧪🧬
November 19, 2024 at 9:04 AM
Fantastic third instalment of the Melbourne Epigenetics Club featuring talks by Lee Wong and Hamish King, and a networking reception
If you’re in Melbourne and interested in #chromatin #epigenetics or #GeneRegulation and interested in attending, visit www.eckmaslab.com/melbourne-ep... 🧪🧬
If you’re in Melbourne and interested in #chromatin #epigenetics or #GeneRegulation and interested in attending, visit www.eckmaslab.com/melbourne-ep... 🧪🧬
Recent lab retreat to Daylesford- a spa town just north of Melbourne. We stepped back from the details of our projects to ask if we were chasing the right questions in the most effective way. Lots of good food and fun was had too!
November 14, 2024 at 8:56 PM
Recent lab retreat to Daylesford- a spa town just north of Melbourne. We stepped back from the details of our projects to ask if we were chasing the right questions in the most effective way. Lots of good food and fun was had too!
Celebrating our lab’s first paper acceptance! Amazing way to start 2024 🥳🧪🧬
January 12, 2024 at 8:33 AM
Celebrating our lab’s first paper acceptance! Amazing way to start 2024 🥳🧪🧬
Lovely paper on BivalentChromatin in fungal invasion by Qin Gu's lab. reChIP in F. graminearum before/after infecting wheat heads reveals bivalency changes to silence genes involved in infection, potentially to host detection
🧪🧬
www.nature.com/articles/s41...
🧪🧬
www.nature.com/articles/s41...
January 11, 2024 at 12:09 AM
Lovely paper on BivalentChromatin in fungal invasion by Qin Gu's lab. reChIP in F. graminearum before/after infecting wheat heads reveals bivalency changes to silence genes involved in infection, potentially to host detection
🧪🧬
www.nature.com/articles/s41...
🧪🧬
www.nature.com/articles/s41...
Celebrating a wonderful 2023 with the lab. Turns out Scientists can paint too!
Wishing everyone a happy festive season and new year. Excited to see what 2024 brings! 🧬🧪
Wishing everyone a happy festive season and new year. Excited to see what 2024 brings! 🧬🧪
December 20, 2023 at 9:40 PM
Celebrating a wonderful 2023 with the lab. Turns out Scientists can paint too!
Wishing everyone a happy festive season and new year. Excited to see what 2024 brings! 🧬🧪
Wishing everyone a happy festive season and new year. Excited to see what 2024 brings! 🧬🧪