Melissa McEvoy
@melissamcevoy.bsky.social
OHSU Ph.D. Candidate
Saldivar Lab
Saldivar Lab
Reposted by Melissa McEvoy
Dear Colleagues,
Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊
We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics.
👉 rdcu.be/e1bBt
Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊
We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics.
👉 rdcu.be/e1bBt
PAF15–PCNA exhaustion governs the strand-specific control of DNA replication
Nature - PCNA–PAF15 has a key role in determining replisome dynamics during genome replication and protecting against genome instability.
rdcu.be
January 29, 2026 at 6:30 PM
Dear Colleagues,
Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊
We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics.
👉 rdcu.be/e1bBt
Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊
We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics.
👉 rdcu.be/e1bBt
Reposted by Melissa McEvoy
I am excited to share the first paper from the Saldivar lab! A special thank you to all who contributed.
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability
Marmolejo et al. uncover transcription condensate dynamics at histone locus bodies
across the cell cycle. These dynamics are governed by cell cycle (DDK and CDK1/2)
and checkpoint (ATR-CHK1) kinases t...
www.cell.com
February 4, 2026 at 4:06 PM
I am excited to share the first paper from the Saldivar lab! A special thank you to all who contributed.
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...
Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability: Molecular Cell www.cell.com/molecular-ce...