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Mark Groeneveld

@mgroeneveld.bsky.social

210 followers 170 following 140 posts

Writing "Open MDMA: An Evidence-Based Synthesis, Theory, and Manual for MDMA Therapy Based on Predictive Processing, Complex Systems, and the Defense Cascade" https://osf.io/preprints/psyarxiv/aps5g

osf.io

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Mark Groeneveld @mgroeneveld.bsky.social · 15d

I feel that describing the phenomenon as a cessation of consciousness is presumptuous, since it's not possible to determine whether subjective awareness is truly absent. The self-reported memory of a perception of non-consciousness could instead be memory disruption.

Mark Groeneveld @mgroeneveld.bsky.social · 23d

It sounds like the sort of thing Daniel Ingram talks about in Mastering the Core Teachings of the Buddha. Events on the progress of insight. Maybe starting the path?

Mark Groeneveld @mgroeneveld.bsky.social · Sep 3

Thanks. I downloaded the paper PDF and saw that when I zoomed in on some of the figures the axis labels were too fuzzy to read. Figure 2A for example.

Mark Groeneveld @mgroeneveld.bsky.social · Aug 19

Can you at least give an order-of-magnitude timeline? Days, weeks, months? I need to know if I need to find an alternative hosting site, how much effort I should put into contacting people who were depending on the OSF DOI working, etc.

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Mark Groeneveld @mgroeneveld.bsky.social · Aug 19

3) Showing logged-out readers an accurate explanation of why the article is not available instead of "page not found." 4) Explaining how long moderation will take.

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Mark Groeneveld @mgroeneveld.bsky.social · Aug 19

I only found out about this by accident when I couldn't access my preprint. I would like to strongly suggest 1) Notifying users about the switch (preferably in advance) 2) Explaining the switch on a preprint's webpage

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Mark Groeneveld @mgroeneveld.bsky.social · Aug 15

What is the title of the paper? The link expired.

Mark Groeneveld @mgroeneveld.bsky.social · Aug 8

During my first MDMA therapy session I had the deeply felt insight that craving and aversion (prediction error?) was the root of all suffering. I also thought that if I could just understand everything correctly I wouldn't suffer any more.

Mark Groeneveld @mgroeneveld.bsky.social · Aug 1

4) Reviewing most practically-relevant aspects of MDMA therapy in the form of a manual

Mark Groeneveld @mgroeneveld.bsky.social · Aug 1

3) Framing practically-useful MDMA therapy in terms of that mechanistic synthesis

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Mark Groeneveld @mgroeneveld.bsky.social · Aug 1

2) Synthesizing multiple mechanistic frameworks of mental illness and therapeutic change into an integrated whole

Mark Groeneveld @mgroeneveld.bsky.social · Aug 1

I think it really shines in:
1) Theorizing the interface between MDMA therapy and predictive processing

Mark Groeneveld @mgroeneveld.bsky.social · Jul 30

I finally have a mostly complete first draft of my MDMA therapy book/manual! It's built on predictive-processing/memory-reconsolidation, complex systems dynamics, and the defense cascade model of autonomic threat responses. I'd love any feedback anyone would like to offer.

OSF

osf.io

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Mark Groeneveld @mgroeneveld.bsky.social · Jul 15

Does anyone know why there is so much caution around mixing MDMA with a history of psychosis or mania, when there aren't that many case reports of MDMA inducing psychosis (and none that I could find of mania), and a large majority of those involve confounding factors not present in therapy?

Mark Groeneveld @mgroeneveld.bsky.social · Jul 11

I know you got MDMA.

Mark Groeneveld @mgroeneveld.bsky.social · Jul 11

I also resonated with your hindsight description of how valuable it was to you. I think I would have accepted a 50% chance of death for MDMA therapy. Without it I probably wouldn't have managed my relationship with my partner, might not be alive anyway, etc.

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Mark Groeneveld @mgroeneveld.bsky.social · Jul 10

I love your article. One of the reasons I never applied for a trial was because I also felt like I couldn't cope with the chance of getting placebo.

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Mark Groeneveld @mgroeneveld.bsky.social · Jul 2

What documents establish that Erik Ahlbrand is Sasha Sisko?

Mark Groeneveld @mgroeneveld.bsky.social · Jun 30

That's been my consistent experience too. Similarly, MDMA seems to facilitate some type of extraordinary prediction error that can reconsolidate most, if not all maladaptive fear and anger responses.

Mark Groeneveld @mgroeneveld.bsky.social · Jun 27

Will we be able to watch recordings? I'm quite interested.

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Mark Groeneveld @mgroeneveld.bsky.social · Jun 20

Could be an artifact of which patients responded to the long term followup. It's unclear because they haven't published the paper yet, just some powerpoint slides.

Mark Groeneveld @mgroeneveld.bsky.social · Jun 20

Huh. The MAPP1&2 long term follow-up found that those who got MDMA were much more likely to have gotten (Or were currently getting during the trial? It's unclear.) vaccinated or use psychiatric medications than those who got placebo. Page 88.
www.fda.gov/media/179062...

www.fda.gov

Mark Groeneveld @mgroeneveld.bsky.social · Jun 18

Do these categorization schemes really matter? It seems to me many of these disorders/problems can all be lumped together as just infinite variations of "maladaptive learned fear predictions that sometimes activate hyper- or hypo-active defense-cascade states."

Mark Groeneveld @mgroeneveld.bsky.social · Jun 17

I might decide the price is worth it when it's time to review my own book prior to sending it off. In the meantime it's a bit pricey!

Mark Groeneveld @mgroeneveld.bsky.social · Jun 17

Claude Code might perform this task better. It is designed to do large numbers of tasks autonomously. That might work especially well with a tool for downloading article pdf's for Claude to read. Presumably journals could build this infrastructure and make it work well.

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