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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · 16d

Heads up, #ReprodSci community!
Interested in the impact of #MaternalAge on #OocyteQuality? Do not miss the latest #EditorChoice article, where the authors explored the transcriptome signature of age-related decline in oocyte quality.
📚🔗👇

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · 16d

Dive into this fascinating #review on #spermatogonial stem cell and fibroblast growth factor #signaling recently published in #MHR!
📚🔗👇
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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · 16d

📣“ACTRT2 deficiency increases #spermatogonia vulnerability to #ferroptosis”
📚🔗Have a look at the article 👇
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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Sep 3

📣”#Fertility is compromised after oocyte-specific #deletion of microtubule severing protein #KataninA1”

#oocytecompetence #meiosis #microtubules #spindle

📚🔗Dive into the full article 👇
academic.oup.com/molehr/artic...

Fertility is compromised after oocyte-specific deletion of microtubule severing protein Katanin A1

Abstract. Katanins are microtubule severing enzymes that play roles in diverse cell functions including meiotic and mitotic spindle formation. To address t

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Sep 3

The winner🥇will be invited to receive their #award and #present their publication at the #MHRSymposium during the Annual Meeting #ESHRE2026 in London!

They will also receive free meeting registration, and travel and accommodation expenses from ESHRE!
@eshre.bsky.social @oupacademic.bsky.social

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Sep 3

✨Are you an early career scientist within 10 years of an independent position?
Submit your innovative #research in #MHR Early Career Innovator Series by the end of September and #compete for the 2025 Early Career Innovator Award!!

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MHR Early Career Innovator Series

MHR is pleased to announce that our Early Career Innovator Series was tremendously successful in its first year and will be continuing throughout 2025 (and beyo

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Sep 3

✨Congrats to all authors and the #ECI Dr Fei Zhao.
Dr Zhao at the University of Wisconsin-Madison focuses his research on elucidating cellular and molecular mechanisms underlying sexual differentiation of reproductive tracts.

MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Sep 3

In this study, the authors investigate the cellular and molecular mechanisms of Wnt9b in WD maintenance in male embryos.

Check out the full article here: academic.oup.com/molehr/artic...

Wnt9b enables androgen action to maintain Wolffian ducts in mice

Abstract. The Wolffian duct (WD) is the embryonic primordium that gives rise to the epididymis, vas deferens, and seminal vesicle. The androgen action in t

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Sep 3

The #androgen action is the main driver for fetal Wolffian duct (WD) maintenance, which is essential for #malefertility. However, the androgen’s capability of promoting WD maintenance is lost in the #absence of #Wnt9b in mice.

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Sep 3

Just back from vacation 🏖️ and looking for a great read? Dive into #MHR latest article in the Early Career Innovator Series on #fetal reproductive organ #development.
academic.oup.com/molehr/pages...

MHR Early Career Innovator Series

MHR is pleased to announce that our Early Career Innovator Series was tremendously successful in its first year and will be continuing throughout 2025 (and beyo

academic.oup.com

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 17

Congrats to the authors and all those involved!!
@Amilia Zisiadi @Ellen Anckaert

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 17

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A matrix-free 3D in vitro follicle culture system in mice exhibits enhanced oocyte meiotic and developmental competence compared to hydrogel encapsulation

Abstract. In vitro follicle culture (IFC) is an emerging fertility preservation alternative for women and children with cancer. Because two-dimensional (2D

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 17

✨A comparative study of different 3D mouse in vitro #follicleculture methods reveals that the matrix-free non-attachment system is more efficient than complex encapsulation methodologies, sustaining high oocyte meiotic and developmental competence.

#EditorChoice
Free to read 🔗📚

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 17

In vitro follicle culture is an emerging #FertilityPreservation solution for women and children with cancer. Recent advances have yielded various 3D methods that preserve follicular structure.
Which is the best?🧐

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 17

“Early signaling pathways during in vitro culture of isolated primordial follicles”

Don’t miss this interesting piece investigating the main transcriptional events and molecular factors determining follicle fate 🧫🐮

Dive into the full article 🔗👇
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Early signaling pathways during in vitro culture of isolated primordial follicles

Abstract. The ability to grow undifferentiated oocytes in vitro from primordial follicles would increase the availability of fully grown oocytes in fertili

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 16

www.linkedin.com/posts/albert...

🚨 𝐒𝐚𝐯𝐞 𝐭𝐡𝐞 𝐝𝐚𝐭𝐞! | Alberto de la Iglesia

🚨 𝐒𝐚𝐯𝐞 𝐭𝐡𝐞 𝐝𝐚𝐭𝐞! 🚨 Join us on 𝐎𝐜𝐭𝐨𝐛𝐞𝐫 𝟏𝟔𝐭𝐡, 𝟐𝟎𝟐𝟓 🗓️ for the upcoming #POHaD symposium that Julie Cocquet and I are organizing together with GDR Reproduction. This meeting, focused on the 𝐏𝐚𝐭𝐞𝐫𝐧𝐚𝐥 𝐎𝐫...

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 16

The #POHaD symposium will gather international scientists interested in how male germ cells are sensitive to external exposures and the impacts beyond fertilization.
Don’t miss this great opportunity!

Registration form - POHaD GdR Symposium

By filling this form, you will confirm your registration to the upcoming POHaD hybrid Symposium taking place next October 16th, 2025. Registration is free of cost but mandatory. Abstract submission is...

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 16

🚨Save the date for the Symposium on the Paternal Origins of Health and Disease!

🗓️October 16th, 2025
📍Institut Cochin (Paris, France) and online
🔗 Registration👇👇

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 9

Marr et al. discusses the use of #organoids as an emerging technology to study endometriosis, and the possibility to develop more complex organoid systems (assembloids) that reflect the interplay of multiple cell types in vivo.
academic.oup.com/molehr/artic...

WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Organoids): endometrial organoids as an emerging technology for endometrios...

Abstract. The aetiology of endometriosis remains poorly understood. In vitro model systems provide the opportunity to identify the mechanisms driving disea

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 9

Dodds et al. examines the methods to assess #pain-associated behaviors in rodent models of endometriosis, and offers best practice recommendations for conducting such tests, aiming to improve study comparability.
academic.oup.com/molehr/artic...

WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis

Abstract. Pain is a debilitating symptom of endometriosis, and its mechanisms are often explored using rodent models. However, a lack of harmonization amon

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 9

Hull et al. focuses on #heterologous rodent models. In this case, what can be standardized includes tissue placement, hormonal status, and the housing conditions for mice with compromised immune systems.
academic.oup.com/molehr/artic...

WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Heterologous): heterologous rodent models

Abstract. Endometriosis, defined as the growth of endometrial-like tissues outside the uterus, is a common disease among women. Numerous in vivo rodent mod

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 9

Burns et al. discusses the use of #homologous rodent models, which mainly consist of the intraperitoneal transplantation of uterine tissue, and the importance to define standardizing parameters, such as method of induction, and ectopic tissue placement.
academic.oup.com/molehr/artic...

WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models

Abstract. In vivo models of endometriosis enable the discovery and preclinical testing of new therapies. Several rodent models of endometriosis exist, but

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 9

This remarkable initiative brings together 44 collaborators from 11 countries, resulting in the publication of 1 #editorial and 4 #articles in the latest issue of Molecular Human Reproduction!

@endometriosis #womenshealth
academic.oup.com/molehr/artic...

Enhancing collaboration in endometriosis research through the initiative of the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project (EPHect)

Endometriosis affects an estimated >200 million women (and those assigned female at birth) during their most active and reproductive years, causing a hi

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 9

✨Exciting news!✨
The World Endometriosis Research Foundation (#WERF) – Endometriosis Phenome and Biobanking Harmonisation Project (#EPHect) today publishes #SOPs to optimize the use of experimental in vivo and in vitro models in #endometriosis research.

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MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jul 1

🤩 See you soon at the #MHRsymposium!!

📍 Session 53, Tuesday from 14:00-15:15

Oxford University Press
@eshre.bsky.social

MHR | Foundations of Reproductive Science @mhr-reprodsci.bsky.social · Jun 25

✨The #ESHRE Annual Meeting 2025 is just around the corner!

Join us at the #MHRsymposium where MHR’s Editor-in-Chief, @Boiani Michele, and Deputy Editor, @Francesca Duncan, will be hosting the session about Basic principles of ovarian function in vivo and in vitro.