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Mike-ghoul Half-man

@michaelhoffman.bsky.social

16K followers 1.6K following 4.4K posts

Chair, Computational BIology and Medicine Program, Princess Margaret Cancer Centre, University Health Network. Associate Professor, Medical Biophysics, University of Toronto. Disclosures: https://github.com/michaelmhoffman/disclosure/

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Mike-ghoul Half-man @michaelhoffman.bsky.social · Nov 12

I'm at Princess Margaret Cancer Centre and University of Toronto. We have three major interests:

1/Computational methods and #ML for gene regulation data 🧬🖥️
2/Liquid biopsy beyond simple genetic variants (epigenomic, immunogenomic)
3/Reproducibility and robustness of biomedical analysis (esp. #ML)

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 3h

So, she's also a mom.

Case closed.

Reposted by Mike-ghoul Half-man

Prem Thakker ツ @premthakker.bsky.social · 5h

My gosh. After the US bombed multiple boats in the middle of the ocean, murdering people on grounds that they were allegedly "carrying drugs," the US Attorney General says "Just like we did with cartels, we're going to take the same approach, President Trump, with Antifa."

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 3h

Own a property but don't want to clean up your own autumn leaves?

Now that's a real problem.

Mike-ghoul Half-man @michaelhoffman.bsky.social · 3h

Never seen four words that sum up Stephen Holyday better.

Can't find a place to live? That's not my problem.
Can't stop cars from killing you? That's not my problem.
Stuck on a bus forever? That's not my problem.
Children can't get food to eat? That's not my problem.

Matt Elliott @graphicmatt.com · 4h

"I've had smaller developers mention to me that, you know, what a burden the DCs are on them kicking off their project, because they'd like to see it financially viable. And my response is, 'That's not my problem,'" says Holyday

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 4h

Why do people feel like having loud, angry phone conversations on transit? Apart from bothering everyone else, do they not care about everyone else knowing their business?

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 4h

I'm coming around to this wasp wrap thing

Reposted by Mike-ghoul Half-man

Anne Applebaum @anneapplebaum.bsky.social · 5h

"We took the freedom of speech away," says the president

Aaron Rupar @atrupar.com · 5h

Trump: "We took the freedom of speech away because that's been through the courts and the courts said you have freedom of speech, but what has happened is when they burn a flag it agitates and irritates crowds."

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 4h

Wow even Holyday voted yes

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 5h

Chow is going pretty hard on this. I assume it's an electoral winner.

Mike-ghoul Half-man @michaelhoffman.bsky.social · 7h

A No-Prize

Mike-ghoul Half-man @michaelhoffman.bsky.social · 10h

Doug: CASH GRAAAAAAAAAAAAAAAAAAB

Mike-ghoul Half-man @michaelhoffman.bsky.social · 10h

Jesus

Matt Elliott @graphicmatt.com · 10h

Councillor Chernos Lin asks about the highest speed recorded by Toronto's speed cameras. Transportation General Manager Barbara Gray says it was 187 km/h in a 50 km/h zone at Midland & Montgomery — on Jan 25 at 10 p.m.

"That's shocking," says Chernos Lin.

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

Wow, imagine thinking it's acceptable to OWN a potato. I mean honestly

Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

if you’re writing a sentence that sounds like cannibalism but you go “oh that’s fine to say because it’s a potato” (whatever that means) you may want to consider what made you okay with saying that

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

Ah, the old "if we pretend you said something completely different, then that would imply the consequences of the thing we're pretending you said instead of the thing you actually said"

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

"biological name"

Aaron Rupar @atrupar.com · 1d

Bondi: "The judge also would not refer to the defendant by his biological name -- referred to him by the pronouns."

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Reposted by Mike-ghoul Half-man

Michael McDonald @electproject.bsky.social · 1d

The Wall Street Journal reports Trump reassigned federal law enforcement dedicated to stop child sex trafficking to spreading mulch in DC. I wonder why?

Aaron Rupar @atrupar.com · 1d

NOTABLE -- Pam Bondi refuses to answer direct questions about if the FBI has incriminating photos of Trump with half-naked young women, but instead deflects from them by attacking Sen. Whitehouse

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

I did not see until now that he was asked about it on Fox News. Instead of denying he took $50,000 cash in a bag, he insists that he didn't do anything illegal.

That is a very unusual way for someone who did not take $50,000 cash in a paper bag to react to that question. www.cbc.ca/news/world/u...

White House shifts explanation on U.S. border czar accused of taking $50,000 in a paper bag | CBC News

The White House press secretary said on Monday that Tom Homan "never took" $50,000 US in cash from an undercover agent, after a damning report emerged over the weekend. Homan himself was less specific...

www.cbc.ca

Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

He is right, as a member of the public I am very interested in what happened to the 50 grand.

Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

Welch asks what happened to $50,000 in cash Trump's border czar Tom Homan is accused of taking.

Bondi: That was resolved prior to my confirmation as Attorney General.

Welch: There's $50,000. Homan has it or somebody has it. Do you have no interest in knowing where it is?

Bondi: [deflects]

The Bulwark @thebulwark.com · 1d

Welch: "Is there a tape of Mr. Homan that has audio and video of the transfer of the $50,000?"

Bondi: "I don't know the answer."

Welch: "You do know the answer."

Bondi: "Don't call me a liar!"

Welch: "I didn't call you a liar?"

Bondi: "You just said I know the answer!"

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Reposted by Mike-ghoul Half-man

Jeremy Berg @jeremymberg.bsky.social · 2d

I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.

Deafening Quiet from the Scientific Establishment

jeremymberg.github.io/jeremyberg.g...

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jeremymberg.github.io

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

It's a nice $2.5–$3 million house in a wonderful neighbourhood. I'd move in.

Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

No, Yogi Berra had significantly more self-awareness

Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

A+ diplomacy.

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Mike-ghoul Half-man @michaelhoffman.bsky.social · 1d

Neighbour in Beaconsfield Village says that increased density means that *no one* will want to live there.

If he ever finds himself in that situation I would be happy to buy his house from him for $1

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