Michela Maresca
@michelamaresca.bsky.social
Postdoctoral scientist fascinated by gene regulation, chromatin dynamics and cell adaptation in development and disease
Reposted by Michela Maresca
🧩 What breaks when you remove DNA loop extrusion?
Gastruloids show it: not lineage decisions… but morphogenesis.
That’s our contribution to www.science.org/doi/10.1126/...
Huge thanks to the amazing @karissalhansen.bsky.social + @elphegenoralab.bsky.social for leading this fantastic work 🙌
Gastruloids show it: not lineage decisions… but morphogenesis.
That’s our contribution to www.science.org/doi/10.1126/...
Huge thanks to the amazing @karissalhansen.bsky.social + @elphegenoralab.bsky.social for leading this fantastic work 🙌
(5) But can embryonic cell types properly emerge even when loop extrusion is prevented?
Unambiguous gastruloid experiments by
@bracciolilab.bsky.social
in
@dewitlab.bsky.social
: YES, they clearly can.
Even though morphogenesis, which is normally very stereotypical, is pretty screwed up.
Unambiguous gastruloid experiments by
@bracciolilab.bsky.social
in
@dewitlab.bsky.social
: YES, they clearly can.
Even though morphogenesis, which is normally very stereotypical, is pretty screwed up.
November 28, 2025 at 8:57 AM
🧩 What breaks when you remove DNA loop extrusion?
Gastruloids show it: not lineage decisions… but morphogenesis.
That’s our contribution to www.science.org/doi/10.1126/...
Huge thanks to the amazing @karissalhansen.bsky.social + @elphegenoralab.bsky.social for leading this fantastic work 🙌
Gastruloids show it: not lineage decisions… but morphogenesis.
That’s our contribution to www.science.org/doi/10.1126/...
Huge thanks to the amazing @karissalhansen.bsky.social + @elphegenoralab.bsky.social for leading this fantastic work 🙌
Reposted by Michela Maresca
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
November 27, 2025 at 9:59 PM
Here is a copy of last year's Twitter thread explaining our preprint - jump to (21) for the new stuff 👀
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
now revised and journal accepted at www.science.org/doi/10.1126/...
🧵👇
Delighted to share this amazing publication from Hangpeng Li and the @jojdavies.bsky.social Davies lab. This was a fantastic opportunity I had during my PhD with Elzo at NKI @dewitlab.bsky.social. I’m glad to have played a role in this project. Check out the original post below for more details!
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 30, 2025 at 10:35 AM
Delighted to share this amazing publication from Hangpeng Li and the @jojdavies.bsky.social Davies lab. This was a fantastic opportunity I had during my PhD with Elzo at NKI @dewitlab.bsky.social. I’m glad to have played a role in this project. Check out the original post below for more details!
Reposted by Michela Maresca
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Michela Maresca
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
September 2, 2025 at 5:26 PM
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!