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Jan Michiels lab @michielslab.bsky.social · 7d

Professor Tilmann Weber joins #Microbes25!
He’ll share how cutting-edge molecular approaches are uncovering new natural products with big potential in medicine and biotechnology.
📅 Final registration deadline: 23 Oct 2025
🔗 vibbio.tech/Microbes25

Jan Michiels lab @michielslab.bsky.social · 21d

At #Microbes25, we’re honored to host Professor Jörg Vogel, a leading voice in RNA biology and infection research.

📅 Early Bird Deadline: 25 September 2025
🔗 Full program & registration: vibbio.tech/Microbes25

Who are you most looking forward to hearing from at #Microbes25?

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Jan Michiels lab @michielslab.bsky.social · Sep 2

Proud to share our comprehensive literature review on application potential, chemical synthesis and microbial production of α-ketoglutaric acid @chemsocrev.rsc.org

pubs.rsc.org/en/content/a...

α-Ketoglutaric acid as a promising platform chemical for sustainable bio-based industries

The chemical industry is gradually shifting from fossil-derived resources to more sustainable bio-based processes. Natural bio-molecules such as succinic, lactic, and itaconic acid are promising platf...

pubs.rsc.org

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Jan Michiels lab @michielslab.bsky.social · Aug 20

Do you know what microbes can do for you? At #Microbes25, Sarah O'Connor will dive into the potential of microbes as a factory of natural products derived from plants and insects. Abstract submissions are due September 4, 2025: lnkd.in/e4EGJcVR
#MicrobialBiotech #microbes #VIBConf

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Jan Michiels lab @michielslab.bsky.social · May 9

Proud to share our latest work on constraint-based modeling in combination with Optknock to identify gene that improve C12 fatty acid production in E. coli

rdcu.be/eljsg

In silico identification of gene targets to enhance C12 fatty acid production in Escherichia coli

rdcu.be

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Jan Michiels lab @michielslab.bsky.social · May 6

We are looking for an enthusiastic PhD student to join our team! Info here www.kuleuven.be/personeel/jo...

PhD in molecular microbiology

Jan Michiels is looking for a dynamic and highly motivated PhD student to develop a project aimed at unraveling mutational robustness and evolvability in bacteria.

www.kuleuven.be

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Jan Michiels lab @michielslab.bsky.social · May 6

Our colleague Lieze Agten contributed a piece on bacteria taking a nap to EOS. Full text (in Dutch): www.eoswetenschap.eu/gezondheid/s...

Slapende bacteriën: een wake-up call voor dokters!

Ziekmakende bacteriën worden niet alleen resistent tegen antibiotica, ze kunnen behandelingen ook overleven door in een soort slaapstand te gaan. Artsen best...

www.eoswetenschap.eu

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Jan Michiels lab @michielslab.bsky.social · Mar 21

🩸 From RNA-limited samples like blood & tissues to the identification relative abundance of RNA modifications in a short time - The EpiPlex assay, presented at #RNGS25 by Gudrun Stengel of Alida biosciences, makes use of proximity barcoding and engineered binders to specifically detect RNA mods. 🧬

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Jan Michiels lab @michielslab.bsky.social · Mar 20

Our conference stress melted away after an evening filled with a choco-lot of fun at the #RNGS25 social activity at the Chocolate Nation. 🍫

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Jan Michiels lab @michielslab.bsky.social · Mar 20

"Plants don't have specialized immune cells, but individual plant cells can flexibly turn into immune hotspots" - 🌱

@tatsuyanobori.bsky.social presented at #RNGS25 on combining single cell multiome data & spatial transcriptomics to study the genetic regulation of plant-microbe interactions.🧬🦠

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Jan Michiels lab @michielslab.bsky.social · Mar 20

Nanopore sequencing enables detection of DNA methylation profiles! 🧬

Mathilde Geysens showcased a powerful approach to identify episignatures of developmental disorders, offering deeper insights into methylation patterns and paving the way for future diagnostics. #RNGS25

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Jan Michiels lab @michielslab.bsky.social · Mar 20

Interesting poster by Genewiz showing all the complex multiomics info that can be gathered from a single patient sample. 🧬 Additionally, they explored the single cell transcriptome on FFPE tumor tissues and show that better insights in human health can even be obtained from minimal samples. #RNGS25

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Jan Michiels lab @michielslab.bsky.social · Mar 20

At #RNGS25, Kirsten Bos took us on a time travel journey by looking into the ancient DNA of infectious diseases. 🦠 Her talk highlights the importance of genomics to trace the evolution and spread of syphilis, revealing crucial insights to improve our understanding of contemporary diseases.

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Jan Michiels lab @michielslab.bsky.social · Mar 20

Nice overview of the Illumina technology roadmap by Jason Betley at #RNGS25. In his talk, he provided a great perspective on the different Illumina platforms and more specifically on their various innovative and easy-to-use sequencing assays. 🧬

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Jan Michiels lab @michielslab.bsky.social · Mar 20

"Biology is dynamic like a river, you cannot step into the same water twice."

Great talk on unlocking high dimensional biology using evolved next-generation sequencing by Molly He of @elembio.bsky.social this morning at #RNGS25.

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Jan Michiels lab @michielslab.bsky.social · Mar 19

Fun & adventurous talk on microbial dark matter at #RNGS25. 🌋 @jimmysaw.bsky.social presented on harnessing long-read sequencing to enable reconstruction of geothermal bacterial genomes. 🧬 His groundbreaking work brings us one step closer to uncovering biological functions in early life on Earth.

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Jan Michiels lab @michielslab.bsky.social · Mar 19

I am very excited to be reporting on the groundbreaking talks at #RNGS25, together with
@vanshikabidhan.bsky.social
& @saraalidadiani.bsky.social.

Follow me on X (@LabMichiels), LinkedIn (Lieze Agten) and here on bluesky to keep track of this revolutionizing conference! @vibtrainconf.bsky.social

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Jan Michiels lab @michielslab.bsky.social · Mar 15

New work in collaboration with Paul Cos (UAntwerp)

www.sciencedirect.com/science/arti...

Widespread antibiotic heterotolerance in bacteria remains undetected by resistance assays

Despite global efforts, antimicrobial resistance persists. Mechanisms like heterotolerance further undermine antibiotic effectiveness. Testing >1,000 …

www.sciencedirect.com

Reposted by Jan Michiels lab

Sammy Pontrelli @sammy-pontrelli.bsky.social · Mar 13

We are searching for a postdoc in Marine Phytoplankton Metabolism and Carbon Storage! You'll get the chance to work in Belgium to combine high-throughput metabolomics and enzymes to study how microbes naturally sequester atmospheric carbon in organic marine molecules!

t.co/orCCyZhzeh

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Jan Michiels lab @michielslab.bsky.social · Mar 3

🚨The final deadline to register for #RNGS25 is this Wednesday, March 5th!🚨

Make sure to register - You don’t want to miss Prof. Bernard Thienpont (@bernthie.bsky.social)'s fascinating talk on improving patient care by using cell-free DNA methylome analysis.🧬

www.vibconferences.be/events/revol...

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Jan Michiels lab @michielslab.bsky.social · Feb 3

🚨Don’t miss #RNGS25!🚨

🧬Prof. Jimmy Saw, who contributed to the discovery of the fascinating Asgard archaea, will explore how long-read sequencing unlocks microbial dark matter in geothermal habitats.🦠

📆Early bird registration deadline is February 5!
www.vibconferences.be/events/revol...

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Jan Michiels lab @michielslab.bsky.social · Jan 27

Proud to present our latest model of aggregation-induced dormancy, published in #NatureComms @liselotdewachter.bsky.social

rdcu.be/d7EcI

Composition and liquid-to-solid maturation of protein aggregates contribute to bacterial dormancy development and recovery

Nature Communications - Recalcitrant infections are often caused by dormant bacteria, including persisters and viable but nonculturable cells. Here, the authors explore how composition and...

rdcu.be

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Jan Michiels lab @michielslab.bsky.social · Jan 7

🧬Join the #RNGS25 conference from 19-21 March to hear more about the exciting work of Dr. Tatsuya Nobori (@tatsuyanobori.bsky.social) on the single-cell and spatial dissection of plant-microbe interactions. 🌱🦠

📆Abstract deadline approaching: 15 January📆
www.vibconferences.be/events/revol...

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Jan Michiels lab @michielslab.bsky.social · Dec 3

Thrilled to start our Bluesky journey by sharing this exciting work on mapping of antibiotic cross-resistance and collateral sensitivity
@typaslab.bsky.social @nazgulsakenova.bsky.social

rdcu.be/d2gwr

Systematic mapping of antibiotic cross-resistance and collateral sensitivity with chemical genetics

Nature Microbiology - Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. This study presents an approach to...

rdcu.be

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