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This work is a great collaboration with Dr. P.Gourdon from Univ.Copenhagen @ucph.bsky.social and Dr. C.Chalut from IPBS-Toulouse @ipbstoulouse.bsky.social
and the Electron microscopy platform from Centre de Biologie Structurale @cbsmontpellier.bsky.social

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Mickaël Blaise @mickael-blaise.bsky.social · Jun 5

MmpL10 coiled-coil domain extends its porter domain and drives the trimer formation. This coiled-coil domain enables to form a tube like structure that may be involved in transport of glycolipids. As this extension is present in all MmpL it may be a common oligomerization/transport mechanism.

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Mickaël Blaise @mickael-blaise.bsky.social · Jun 5

We demonstrate that the mycobacterial transporter of the trehalose polyphleate precursor named MmpL10, oligomerizes through a rather atypical way for a member of the RND pump superfamily.

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Mickaël Blaise @mickael-blaise.bsky.social · Jun 5

Glad to share J.Couston's @juliecouston.bsky.social
work published at The FEBS Letters @febsletters.bsky.social and done at @irim-life.bsky.social
.
doi.org/10.1002/1873...

FEBS Press

Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate prec...

doi.org

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Mickaël Blaise @mickael-blaise.bsky.social · Jun 5

Thanks to all the other authors and to financial support of the joint program CNRS-Univ.Copenhagen @cnrs.fr @cnrsbiologie.bsky.social, @agencerecherche.bsky.social and @umontpellier.bsky.social .

Reposted by Mickaël Blaise

IPBS Toulouse @ipbstoulouse.bsky.social · May 17

🚨 PhD opportunity in Toulouse!
Join a dynamic team to study membrane proteins & transporters of therapeutic interest using cryo-EM, enzymology & biophysics.

📅 Deadline: June 19, 2025
🔗 Funded by @frm-officiel.bsky.social

#StructuralBiology #MicroSky

More details 👇
shorturl.at/OaVMI

PhD position in structural biology and infectious diseases - IPBS-Toulouse

We are currently looking for highly motivated PhD student with a strong interest in structural[…]

shorturl.at

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Reposted by Mickaël Blaise

CEMIPAI UAR3725 @cemipai.bsky.social · Apr 22

La plateforme CEMIPAI recrute un.e ingénieur.e d'étude en CDD en virologie. Le/la candidat.e aura pour mission de cribler et caractériser l'effet d'antiviraux et d'anticorps sur la réplication de virus émergents de classe 3

emploi.cnrs.fr/Offres/CDD/U...

Portail Emploi CNRS - Offre d'emploi - Ingénieur d'études en Virologie (H/F) CDD 1 an renouvelable

emploi.cnrs.fr

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Mickaël Blaise @mickael-blaise.bsky.social · Apr 17

New study on the regulatory role of the sigma subunit on the M. tuberculosis RNAP conformational dynamics, led by Dr. K.Brodolin @irim-life.bsky.social in collaboration with @emmanuelmargeat.bsky.social from @cbsmontpellier.bsky.social. 👇
academic.oup.com/nar/article/...

Single-stranded DNA drives σ subunit loading onto mycobacterial RNA polymerase to unlock initiation-competent conformations

Abstract. Initiation of transcription requires the formation of the “open” promoter complex (RPo). For this, the σ subunit of bacterial RNA polymerase (RNA

academic.oup.com

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Mickaël Blaise @mickael-blaise.bsky.social · Apr 2

yes I use it now for years instead of illustrator and it is rather easy to switch from illustrator to inkscape.

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Reposted by Mickaël Blaise

IRIM @irim-life.bsky.social · Mar 24

Last week to apply in order to join us as a group leader at @irim-life.bsky.social!

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Reposted by Mickaël Blaise

lucileespert.bsky.social @lucileespert.bsky.social · Mar 23

Very proud of Marie @marieviii.bsky.social (best short talk) and Guilhem (best poster) for their prizes !! Thanks to all the CFATG12 organizers, it was an amazing congress (as usual ;))
@cfatg.bsky.social @irim-life.bsky.social
Thanks to supports @sidaction.bsky.social and @anrs-mie.bsky.social

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Mickaël Blaise @mickael-blaise.bsky.social · Mar 19

glad to see Nocardia !!

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Reposted by Mickaël Blaise

Yves Brun lab @brunlabcaulo.bsky.social · Mar 12

Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to [email protected]. See
lnkd.in/dVVk4N3s. #microsky

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Mickaël Blaise @mickael-blaise.bsky.social · Feb 17

le pb sera reglé pour bon nombre d entre nous de toute façon apres ce premier round...😬

Mickaël Blaise @mickael-blaise.bsky.social · Jan 24

sait on pour sur si on est une quiche ?

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Mickaël Blaise @mickael-blaise.bsky.social · Dec 16

Thx to @juliecouston.bsky.social for this nice Xmas gift: a must have "PhD thesis director survival kit" ...I am pretty sure all these tools will be useful to guide you for the last year of your thesis work...

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Mickaël Blaise @mickael-blaise.bsky.social · Dec 12

ça fait pas rêver...😬

Reposted by Mickaël Blaise

lucileespert.bsky.social @lucileespert.bsky.social · Dec 12

All you want to know about the role of peroxisomes during a viral infection authors.elsevier.com/a/1kFMV3QxxS...
@irim-life.bsky.social @ANRS-MIE @Sidaction @cnrs.bsky.social @Marie Villares @cdaussy.bsky.social

authors.elsevier.com

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