Miguel Hernandez Gonzalez
miguel-virus-cells.bsky.social
Miguel Hernandez Gonzalez
@miguel-virus-cells.bsky.social
Cell Biology. Membranes. Viruses. Cryo-ET.
Reposted by Miguel Hernandez Gonzalez
💥 Another Cryo-ET study from the Way lab by ‪@miguel-virus-cells.bsky.social‬ in collaboration with Rosenthal lab @crick.ac.uk‬ examining Vaccinia virus egress 😀👇 www.biorxiv.org/content/10.1...
In situ cryo-electron tomography of vaccinia virus exit from infected cells
Poxvirus-infected cells release newly assembled virions via Golgi-mediated envelopment and subsequent exocytosis at the plasma membrane, prior to cell lysis. Here, we used cryo-electron tomography and...
www.biorxiv.org
August 20, 2025 at 11:32 AM
Reposted by Miguel Hernandez Gonzalez
Thrilled to share that my first paper in the lab of @drmichaelway.bsky.social is now published in @narjournal.bsky.social!

We showed that Topoisomerase 2α and 2β have opposing roles in vaccinia virus replication, one promoting and the other restricting it 👇🏼

doi.org/10.1093/nar/...
Nonredundant roles of topoisomerase 2α and 2β in the cytosolic replication of vaccinia virus
Abstract. Vaccinia virus is a large enveloped DNA virus, which, like all poxviruses, replicates in the cytoplasm of infected cells. Vaccinia was historical
doi.org
June 26, 2025 at 6:48 PM