Michael Kelberman
@mikekelberman.bsky.social
Donaldson Lab Post-Doc @ CU Boulder 🦬 interested in subcortical contributions to social deficits in Alzheimer's disease | Locus coeruleus enthusiast 🔵
Together these data show that CP-AMPARs in the nucleus accumbens control the progression from social interaction to pair bonding via neuronal and ensemble level encoding
January 9, 2026 at 3:42 PM
Together these data show that CP-AMPARs in the nucleus accumbens control the progression from social interaction to pair bonding via neuronal and ensemble level encoding
CP-AMPARs mediate excitation of fast-spiking interneurons (FSIs) and with electrophysiology we found FSIs coordinate medium spiny neuron ensemble activity.
January 9, 2026 at 3:42 PM
CP-AMPARs mediate excitation of fast-spiking interneurons (FSIs) and with electrophysiology we found FSIs coordinate medium spiny neuron ensemble activity.
Pharmacological blockade of CP-AMPARs blocked pair bond formation. With in vivo calcium imaging, we show that blockade of CP-AMPARs paradoxically disrupts partner neuronal ensemble formation and encoding while increasing the proportion of partner-selective neurons.
January 9, 2026 at 3:42 PM
Pharmacological blockade of CP-AMPARs blocked pair bond formation. With in vivo calcium imaging, we show that blockade of CP-AMPARs paradoxically disrupts partner neuronal ensemble formation and encoding while increasing the proportion of partner-selective neurons.
Happy to discuss whenever you do!
November 15, 2025 at 7:09 PM
Happy to discuss whenever you do!
Together these results suggest LC lesions worsen pre-existing pathology and behavioral dysfunction, rather than accelerate their onset.
Congrats to all co-authors!
Congrats to all co-authors!
November 15, 2025 at 7:04 PM
Together these results suggest LC lesions worsen pre-existing pathology and behavioral dysfunction, rather than accelerate their onset.
Congrats to all co-authors!
Congrats to all co-authors!
Interestingly we found that AD genotype and DSP-4 rarely interacted to affect phenotypes. Instead each factor led to distinct phenotypes like apathy and changes in arousal (DSP-4) or social recognition deficits and anxiety (TgF344-AD).
November 15, 2025 at 7:04 PM
Interestingly we found that AD genotype and DSP-4 rarely interacted to affect phenotypes. Instead each factor led to distinct phenotypes like apathy and changes in arousal (DSP-4) or social recognition deficits and anxiety (TgF344-AD).
We're also looking for funding to support the registration and travel for our attendees, so if you're interested in supporting or know someone who might, please get in touch!
March 20, 2025 at 4:10 PM
We're also looking for funding to support the registration and travel for our attendees, so if you're interested in supporting or know someone who might, please get in touch!
You can add me to the list! Current Post-Doc with Zoe Donaldson (I'll see what I can do to get her to move over)
November 21, 2024 at 2:55 PM
You can add me to the list! Current Post-Doc with Zoe Donaldson (I'll see what I can do to get her to move over)