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Sebastian Shaw

@millseba.bsky.social

210 followers 430 following 57 posts

Dad. Scientist. Interested in how Cryptosoridium tricks its host cells!

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Sebastian Shaw @millseba.bsky.social · 20d

🚨 New paper out! 🚨

🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!

Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics

www.sciencedirect.com/science/arti...

Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection

The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …

www.sciencedirect.com

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Sebastian Shaw @millseba.bsky.social · 19h

Thanks to all co-authors—especially my shared first author Gracyn 🙌

Sebastian Shaw @millseba.bsky.social · 19h

Our latest story on Clofazimine resistance in Cryptosporidium! What started as a side project turned into one of the most interesting stories.

Genetics 101 😊

#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch

www.biorxiv.org/content/10.1...

Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes Cryptosporidium to clofazimine resistance

The parasite Cryptosporidium is a leading cause of life-threatening diarrheal disease, and effective treatment is not available. The discovery of potent anti-Cryptosporidium activity of clofazimine, o...

www.biorxiv.org

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Reposted by Sebastian Shaw

Cryptosporidium Meeting UK 2026 @cryptouk26.bsky.social · 1d

Save the date, next Cryptosporidium meeting in Edinburgh May 22-24, 2026. Register for email updates via the QR code below.

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Sebastian Shaw @millseba.bsky.social · 12d

a pixel art of an airplane with a rainbow coming out of its tail

ALT: a pixel art of an airplane with a rainbow coming out of its tail

media.tenor.com

Sebastian Shaw @millseba.bsky.social · 18d

Also known as “helix-to-heaven”

Sebastian Shaw @millseba.bsky.social · 20d

Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection

The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …

www.sciencedirect.com

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Sebastian Shaw @millseba.bsky.social · 21d

How many red flags more will it take?

Sebastian Shaw @millseba.bsky.social · Aug 21

Congrats Adam, Lucy and Team!! 🥳

Sebastian Shaw @millseba.bsky.social · Aug 17

Kommt auf die Situation drauf an: Hochzeit, eher nein! Zoom meeting, völlig ok.
😉

Sebastian Shaw @millseba.bsky.social · Aug 1

Happy #SwissNationalDay 🇨🇭

Meanwhile, Trump just slapped 39% tariffs on Swiss goods.

How am I supposed to keep up my essential intake of cheese and chocolate? 🧀🍫

Sebastian Shaw @millseba.bsky.social · Jul 16

No ERC Starting Grant this time 😔

7 great reviews — and 1 that… didn’t quite agree.

Time to go all in for the SNSF Starting Grant! 💪🏼 Interview in September 🤞🏻🤞🏻🤞🏻

Sebastian Shaw @millseba.bsky.social · Jun 28

Ignorieren und weiter gehts im Leben

Sebastian Shaw @millseba.bsky.social · Jun 6

“Coachella of molecular parasitologists” 😜

ParasitesRule @parasitesrule.org · Jun 5

Registration and Abstract submission for MPMXXXVI are now open! Abstract submission deadline is June 27th, get yours in quickly. @rmc9z.bsky.social @mjgubbels.bsky.social @omarharb.org
🔗https://www.parasitesrule.com/mpm-xxxvi

Sebastian Shaw @millseba.bsky.social · Jun 4

Just had my ERC Starting grant interview. Now the wait is on! 🤞🏻🤞🏻🤞🏻

Reposted by Sebastian Shaw

Kristian G. Andersen @kgandersen.bsky.social · May 30

Here's the NIH's proposed budget - from $48 billion to $27 billion. NIAID, current ~$7 billion cut to ~$4.2 billion.

The proposed 15% cap on indirect costs remains.

Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.

www.hhs.gov/sites/defaul...

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Reposted by Sebastian Shaw

bioRxiv Genetics @biorxiv-genetic.bsky.social · May 22

Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection https://www.biorxiv.org/content/10.1101/2025.05.20.655157v1

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Sebastian Shaw @millseba.bsky.social · May 22

🚨 Preprint Alert 🚨
We performed genetic crosses between phenotypically different Cryptosporidium strains and identified genomic loci responsible for their differences!

#Cryptosporidium #Genomics #Parasitology #InfectiousDiseases #Preprint #BioRxiv

www.biorxiv.org/content/10.1...

Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection

The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. An array of parasites with similar genomes produce...

www.biorxiv.org

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Reposted by Sebastian Shaw

Nature Microbiology @natmicrobiol.nature.com · May 20

🚨Out now!

scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance by @fra-florini.bsky.social @kirkdeitsch.bsky.social

#MicroSky #Plasmodium 🦠🧬

www.nature.com/articles/s41...

scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance - Nature Microbiology

Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive capacity to maintain chroni...

www.nature.com

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Reposted by Sebastian Shaw

Kirk Deitsch @kirkdeitsch.bsky.social · May 16

Very happy to congratulate @fra-florini.bsky.social and Joe Visone for the publication of their recent work on antigenic variation by malaria parasites: rdcu.be/emjbn and an earlier version here: www.biorxiv.org/content/10.1.... Francesca will present some of this work next week at BioMalPar 2025.

scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance

Nature Microbiology - Single-cell transcriptomics revealed that malaria parasites have unexpected flexibility in surface antigen expression, potentially providing parasites with greater adaptive...

rdcu.be

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Reposted by Sebastian Shaw

Keith Matthews @keithrmatthews.bsky.social · May 16

Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Postdoctoral Research Associate

This project will seek to understand the basis of increased virulence after long term coinfection by a combination of genomic, transcriptomic and laboratory manipulation of the selected parasite lines...

elxw.fa.em3.oraclecloud.com

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Sebastian Shaw @millseba.bsky.social · May 16

Very good question 😅

Sebastian Shaw @millseba.bsky.social · Apr 28

It available in Pennsylvania now. They are going to introduce Malört to Philly as “new citywide combo”. Not sure how that will turn out. 😅

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Sebastian Shaw @millseba.bsky.social · Apr 27

m.youtube.com/watch?v=Aq6j...

Can I make good drinks from Malört? | How to Drink

YouTube video by How To Drink

m.youtube.com

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Sebastian Shaw @millseba.bsky.social · Apr 11

Two toddlers in a sandbox, flinging toys at each other because one wouldn’t share a shovel — each tantrum louder than the last, while the whole playground suffers from the mess.