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Reposted

mitchell-lab.bsky.social @mitchell-lab.bsky.social · Sep 10

Come join us in person for an AI workshop watch party.

Canadian Epigenetics @ceehrc.bsky.social · Sep 9

📢 Join Drs. Ma’n Zawati & James Tsui for a dynamic workshop on the ethics & impact of AI in scientific research.

📍 Attend in Montreal, UBC, or U of T — or join via Zoom!
🗓️ Free & in person with snacks 🍪
🔗 Register: www.eventbrite.com/e/harnessing...

#AI #Genomics #CEEHRC #ScienceEthics

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · 20d

Come work with us in this vibrant and diverse department csb.utoronto.ca

Department of Cell & Systems Biology

The Department of Cell & Systems Biology (CSB) advances research and teaching in some of the most dynamic and vital areas of biological research.

csb.utoronto.ca

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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · 20d

The Department of Cell & Systems Biology at University of Toronto invites applications for a full-time tenure stream position in the field of Animal Morphogenesis.
#CellBiology #DevelopmentalBiology #mechanobiology #TissueMorphogenesis
#SystemsBiology

jobs.utoronto.ca/job/Toronto-...

Assistant Professor - Animal Morphogenesis

jobs.utoronto.ca

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Canadian Epigenetics @ceehrc.bsky.social · 20d

CALL FOR ABSTRACTS!

The deadline for abstract submission (for talk consideration), early-bird rates, and travel award applications for the 2025 CEEHRC Annual Meeting is TODAY, FRIDAY, SEPTEMBER 19!

event.fourwaves.com/...

#epigenetics #ceehrc #epigenomes
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CEEHRC 11th Annual Canadian Conference on Epigenetics

Fourwaves - CEEHRC 11th Annual Canadian Conference on Epigenetics

event.fourwaves.com

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Canadian Epigenetics @ceehrc.bsky.social · 27d

DEADLINE EXTENDED!

Early-bird registration, abstract submission for talk consideration, and travel award application deadline has been extended to FRIDAY, SEPTEMBER 19!

Abstracts submitted after Sep 19 will be included in poster sessions.

event.fourwaves.com/...
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mitchell-lab.bsky.social @mitchell-lab.bsky.social · Sep 10

Come join us in person for an AI workshop watch party.

Canadian Epigenetics @ceehrc.bsky.social · Sep 9

📢 Join Drs. Ma’n Zawati & James Tsui for a dynamic workshop on the ethics & impact of AI in scientific research.

📍 Attend in Montreal, UBC, or U of T — or join via Zoom!
🗓️ Free & in person with snacks 🍪
🔗 Register: www.eventbrite.com/e/harnessing...

#AI #Genomics #CEEHRC #ScienceEthics

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Reposted

Pedro Rocha @pedroprocha.bsky.social · Sep 8

🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...

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Reposted

FragileNucleosome @fnucleosome.bsky.social · Sep 1

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...

Fragile Nucleosome Fall Seminars:
September 10 Grace Bower, Kvon Lab @ UC Irvine, USA
Jennifer Phillips-Cremins, UPenn, USA

September 24 Ali Wilkening, Sanulli Lab @ Stanford, USA
Juanma Schvartzman, Columbia University, USA

October 8 Sanim Rahman, Greenberg Lab @ UPenn, USA
Alex Federation, Talus Bio, USA

October 22 Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland
Seungsoo Kim, UC Irvine, USA

November 5 Hannah Long, University of Edinburgh, UK
Jeff Vierstra, Altius Institute, USA

November 19 Ishtiaque Hossain, Pastor Lab @ McGill, Canada
Sarah Teichmann, University of Cambridge, UK

December 3 María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain
Jonathan Henninger, Carnegie Mellon, USA

December 17 Rebecca Berrens, Oxford University, UK
Jean-Benoit Lalanne, University of Montreal, Canada

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · Sep 8

Our latest is online now, we discovered that enhancers cause surrounding chromatin to acquire euchromatin modifications and produce non-coding RNA making regions without enhancer activity look like enhancers. doi.org/10.1101/2025...

Enhancers mediate euchromatin hopping at chromatin contact points

Enhancer-mediated gene activation involves the recruitment of chromatin modifiers and RNA polymerase to target promoters, but it is unknown if enhancers influence chromatin beyond their target genes. ...

doi.org

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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · Aug 15

🧪🌱Plants started off as aquatic organisms. But how did they make the jump to land?
The Christendat lab show in @molbioevol.bsky.social that SKL1 is necessary for chloroplast formation and this function is conserved in land plants from liverworts to flowering plants!
www.utoronto.ca/news/researc...

Researchers identify protein that evolved to enable plants to thrive on land

Evolutionary plant biologists at the University of Toronto have identified a protein that evolved approximately 500 million years ago that enables plants to convert light into energy through photosynt...

www.utoronto.ca

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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · Jul 31

#DYK there is #SciArt on display around the CSB Buildings @utoronto.ca?
Keep your eyes open for gorgeous images created by our @uoftartsci.bsky.social students, from their research and as artwork
You can also view these images in our online gallery!
csb.utoronto.ca/research-ove...

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Reposted

Canadian Epigenetics @ceehrc.bsky.social · Jul 24

The CEEHRC Annual Meeting returns this fall!

Register NOW for the 11th Canadian Conference on Epigenetics taking place November 12-15, 2025 at the Banff Centre for Arts and Creativity in Banff, Alberta.

event.fourwaves.com/...
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CEEHRC 11th Annual Canadian Conference on Epigenetics

Fourwaves - CEEHRC 11th Annual Canadian Conference on Epigenetics

event.fourwaves.com

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · Jul 8

Welcome Felix, we’re thrilled to have you join CSB@UofT

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · Jun 3

Our study of how the AP1 transcription factor JUND regulates gene expression during human pregnancy is out now in @PLOS Genetics can01.safelinks.protection.outlook.com?url=https%3A...

JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium

Author summary The muscular layer of the uterus, is responsible for the forceful contractions that deliver the baby at the end of pregnancy. During the majority of pregnancy this muscle is not able to...

can01.safelinks.protection.outlook.com

mitchell-lab.bsky.social @mitchell-lab.bsky.social · May 1

It’s a pun-tastic research day @uoftcellsysbiol.bsky.social

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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · Apr 17

CSB students from @uoftartsci.bsky.social networked with alumni during a recent Backpack to Briefcase speed mentorship reception with @uoftalumni.bsky.social. Check out the story for career tips and examples of potential career paths!

b2B speed networking event: connecting CSB students and alumni through shared experiences and snacks - Department of Cell & Systems Biology

CSB students networked with alumni during a recent speed mentorship reception. Along with specific career advice, students learned a few common themes for the modern job market

csb.utoronto.ca

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Reposted

WHO @who.int · Apr 7

It's #WorldHealthDay
Since 2000, maternal deaths globally declined by 40%! 💙

BUT—progress is slowing, and aid funding cuts mean major threats to lifesaving maternity services in many parts of the world. ❌

Access alone is not enough; people need high-quality care.

Fewer women are dying in childbirth as access to health care has increased.

Maternity service coverage has increased.

Access to health care saves lives. Pregnancy can be a dangerous time in a woman's life.

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University of Toronto @utoronto.ca · Mar 26

Melanie Woodin, an internationally recognized neuroscientist who studies the mechanisms underlying learning and memory in the brain, has been named #UofT’s 17th president. ➡️ uoft.me/uoftpres

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Cell & Systems Biology (CSB) @uoftcellsysbiol.bsky.social · Feb 11

As you scroll through our skeets, you’ll see that women scientists are vital to discoveries made at CSB.
For International Day of Women & Girls in Science, we’ve highlighted some recent impressive accomplishments #IDWGS2025 #WomenInScience
csb.utoronto.ca/supporting-t...

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · Feb 12

Supporting the talented women scientists of CSB on IDWGS csb.utoronto.ca/supporting-t...

Supporting the Talented Women Scientists in CSB on IDWGS - Department of Cell & Systems Biology

We are proud to recognize the accomplishments of the women scientists in CSB on 2025's International Day of Women & Girls in Science and to offer our support all year long

csb.utoronto.ca

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · Jan 30

This was a big collaborative effort started by Sakthi D Moorthy, now at CCRM, and brought to the finish by @itobiaslab.bsky.social now at @uofguelph.bsky.social
Thank you to all the team and to CIHR for funding our efforts to understand gene expression regulation in the brain!

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · Jan 30

The cells missing SRR2-18 shift their transcriptome and accessible chromatin away from the developing forebrain to a state more similar to the neural tube.

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · Jan 30

Deleting the Sox2 SRR2-18 enhancer cluster on both alleles causes a loss of neural stem cell self renewal at higher passages.

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · Jan 30

Our work on the enhancers regulating Sox2 in neural stem cells is published! This one has been a long time in the works. We found a cluster of downstream enhancers, including the more well studied SRR2, are required to maintain Sox2 expression and anterior neural identity.
doi.org/10.1093/g3jo...

A Sox2 Enhancer Cluster Regulates Region-Specific Neural Fates from Mouse Embryonic Stem Cells

Abstract. Sex-determining region Y box 2 (Sox2) is a critical transcription factor for embryogenesis and neural stem and progenitor cell (NSPC) maintenance

doi.org

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mitchell-lab.bsky.social @mitchell-lab.bsky.social · Dec 14

Career achievement unlocked - two publications come out on the same day!

Great collaboration with Tom Sexton
doi.org/10.1126/scia...

And fantastic work by Tiegh Taylor and Mitchell lab colleagues
journals.plos.org/plosgenetics...

Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics

Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.

doi.org

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