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Mike Murphy @mitoredox.bsky.social · 9d

In Toronto today giving a seminar at the Sick Kids Research Institute on "Mitochondria in Ischemia-Reperfusion Injury: From Basic Science to Potential Therapies"
Great to catch up with previous lab member now in Toronto - Thomas Hurd, Ellen Robb and Anna Dare.

Mike Murphy @mitoredox.bsky.social · Aug 14

Great to see this paper out - another Krieg/Murphy collaboration - and congratulations to Jordan Lee who did most of the work!

academic.oup.com/cardiovascre...

Local arterial administration of acidified malonate as an adjunct therapy to mechanical thrombectomy in ischemic stroke

AbstractAims. Ischemic stroke is increasingly treated by mechanical thrombectomy (MT) with the more rapid and complete reperfusion of the ischemic tissue,

academic.oup.com

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Mike Murphy @mitoredox.bsky.social · Aug 13

Great to see Hiran Prag setting up his lab at the University of Manchester - I'm expecting great things!

personalpages.manchester.ac.uk/staff/hiran....

Prag Lab - Coming Soon

personalpages.manchester.ac.uk

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Mike Murphy @mitoredox.bsky.social · Jul 17

It was wonderful to see the NEJM paper today about healthy babies born free of mtDNA disease following mitochondrial donation. Built on decades of work led by Doug Turnbull and his team in Newcastle.

www.nejm.org/doi/full/10....

Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease | NEJM

Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc...

www.nejm.org

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Mike Murphy @mitoredox.bsky.social · Jul 17

It was a great pleasure to attend last week Professor Dunja Aksentijevic's inaugural Professorial Lecture at Queen Mary, University of London. Dunja, it's just the start!

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Mike Murphy @mitoredox.bsky.social · Jun 27

Congrats to Helena Cocheme @cochemelab.bsky.social on her paper on redox regulation of autophagy in Drosophila.
doi.org/10.1038/s414...

Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications

Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

doi.org

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Mike Murphy @mitoredox.bsky.social · Jun 26

Good day yesterday at the William Harvey Research Institute Research Day where I was honoured to receive the Derek Willoughby Medal and give a lecture. Great hospitality from Dunja Aksentijevic and Sir Mark Caulfield.

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Mike Murphy @mitoredox.bsky.social · Jun 14

doi.org/10.1038/s414...

Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis - Nature Communications

Clonal hematopoiesis is driven by the selective advantage of mutant hematopoietic stem cells. Here, authors discover that elevated mitochondrial activity is a targetable mechanism by which mutant hema...

doi.org

Mike Murphy @mitoredox.bsky.social · Jun 14

doi.org/10.1038/s415...

Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs - Nature

Dnmt3a mutations in mouse haematopoietic stem and progenitor cells equivalent to R882 mutations in human cause increased mitochondrial respiration, suggesting that this is a mechanism of clonal h...

doi.org

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Mike Murphy @mitoredox.bsky.social · Jun 14

Series of interesting papers showing that haematopoietic stem cells can undergo damaging clonal haematopoiesis when they acquire mutations that enhance mitochondrial respiration - opening the way to using metformin - and my beloved MitoQ - to prevent this transition.

doi.org/10.1038/s415...

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis - Nature

Metformin may serve as a non-toxic intervention to inhibit mitochondrial metabolism and slow DNMT3A-R882 clonal haematopoiesis expansion, thus delaying or averting progression to acute myeloid le...

doi.org

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Mike Murphy @mitoredox.bsky.social · Jun 9

Congrats to Dunja Aksienijevic on her latest paper!

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Mike Murphy @mitoredox.bsky.social · Jun 4

By the Atlantic in Galway at the SFRRI meeting - catching up with old friends and new.

www.sfrrgalway2025.com

22nd SFRRI Biennial Meeting I Galway I June 3-6, 2025

Information, Program, Registration, Abstract Submission for the 22nd SFRRI Biennial Meeting

www.sfrrgalway2025.com

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Mike Murphy @mitoredox.bsky.social · May 29

Shows convincingly that that obesity increases mitochondrial ROS by RET in the liver in vivo to drive insulin resistance. This is proposed to be due to defects in CoQ biosynthesis - some fascinating findings here that will take time to explore by the community.

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Mike Murphy @mitoredox.bsky.social · May 29

Congrats to Renata Goncalves who led a study in Gokhan Hotamisligil's lab that has just come out in Nature - ably assisted by Jillian Riveros!

www.nature.com/articles/s41...

CoQ imbalance drives reverse electron transport to disrupt liver metabolism - Nature

Reverse electron transport is the mechanism behind excess mitochondrial reactive oxygen species in the livers of obese mice, which has implications for developing therapeutics for fatty liver dis...

www.nature.com

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Mike Murphy @mitoredox.bsky.social · May 24

Congratulations to Abigail Giles who was awarded the "The Richard J. Bing Award for Young Investigators" at the recent World Congress of the International Society For Heart Research in Japan.

Well done Abigail!

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Mike Murphy @mitoredox.bsky.social · May 22

Congratulations to @clarebryant.bsky.social on her election to the Academy of Medical Sciences!

Mike Murphy @mitoredox.bsky.social · May 22

Congrats to Ana Vujic on her latest paper!

journals.physiology.org/doi/abs/10.1...

Loss of RET-ROS at complex I induces diastolic dysfunction in mice that is reversed by aerobic exercise | American Journal of Physiology-Heart and Circulatory Physiology | American Physiological Socie...

Central to the development of heart failure with preserved ejection fraction (HFpEF) is the redox disruption of metabolic processes, however, the underlying mechanisms are not fully understood. This s...

journals.physiology.org

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Mike Murphy @mitoredox.bsky.social · May 20

Delighted to be a small part of this paper led by Alicia, Brian and Simon.

doi.org/10.1038/s414...

CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition - Nature Communications

CREBBP mutations in B-cell acute lymphoblastic leukemia (B-ALL) are linked to poor prognosis and chemoresistance. Here, the authors show that genetic or pharmacological inactivation of CREBBP sensitiz...

doi.org

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Reposted by Mike Murphy

Simon Richardson @simonrichardson.bsky.social · May 20

Delighted that our work describing a potential novel treatment approach for B-cell Acute Lymphoblastic Leukaemia is published today in @natcomms.nature.com‬. 🧵

www.nature.com/articles/s41...

CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition - Nature Communications

CREBBP mutations in B-cell acute lymphoblastic leukemia (B-ALL) are linked to poor prognosis and chemoresistance. Here, the authors show that genetic or pharmacological inactivation of CREBBP sensitiz...

www.nature.com

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Mike Murphy @mitoredox.bsky.social · May 18

Pleased to have been elected a Member of Academia Europaea. Thanks to Mike Davies of Copenhagen for nominating me.

www.ae-info.org/ae/Member/Mu...

Academy of Europe: Murphy Michael

www.ae-info.org

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Mike Murphy @mitoredox.bsky.social · Apr 29

IMS-MRL External Seminar (Cambridge)
Tuesday 6 May 2025 at 13.15

Professor Mike Murphy,

Understanding how mitochondria contribute to ischaemia-reperfusion injury

HOST: Professor Steve O’Rahilly

Hybrid Seminar in the IMS-MRL Seminar Rooms (for IMS staff), Online for others

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Mike Murphy @mitoredox.bsky.social · Apr 25

At the University of Cordoba today giving a seminar in the department of Prof Raquel Requejo. She used to be post-doc in my lab in Cambridge and is now running her own lab.

www.uco.es/dptos/bioqui...

Departamento de Bioquímica y Biología Molecular - Universidad de Córdoba

www.uco.es

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Mike Murphy @mitoredox.bsky.social · Apr 24

Visiting IBIS in beautiful Sevilla www.ibis-sevilla.es/en/
Hosted by José López-Barneo - giving a seminar there today.

IBiS

www.ibis-sevilla.es

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Mike Murphy @mitoredox.bsky.social · Apr 9

Important new paper in Nature from Gero Miesenböck's lab showing that the accumulation of lipid peroxidation products from mitochondrial ROS production leads in sleep.

doi.org/10.1038/s415...

Sleep pressure accumulates in a voltage-gated lipid peroxidation memory - Nature

Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state o...

doi.org

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Mike Murphy @mitoredox.bsky.social · Apr 4

Congrats to Michal Minczuk @mitogene.bsky.social and all at Pretzel Therapeutics on initiation of their first Phase I trial!

www.pretzeltx.com/pretzel-ther...

Pretzel Therapeutics Initiates Phase 1 Clinical Study Evaluating PX578, Lead Therapeutic in its Bioenergetics Restoration Franchise » Pretzel Therapeutics

First-in-class approach to targeting mitochondrial DNA polymerase (POLG) with disease modifying potential across mitochondrial DNA depletion syndromes

www.pretzeltx.com

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