Michael Le Page
@mjflepage.bsky.social
2.3K followers 1.2K following 2.8K posts
Award-winning reporter at New Scientist who clings to the belief that good journalism mattters. I write about life on Earth, inc climate ☀️, food 🍱, CRISPR 🧬 and biomed 💊 My bio & stories: https://www.newscientist.com/author/michael-le-page
Posts Media Videos Starter Packs
Pinned
mjflepage.bsky.social
This is incredible - early stage research suggests drugs based on mRNA vaccine technology could protect against just about any virus 🦠 🧪

Essentially, the mRNAs turn on innate defences ahead of infection, which can give the body a crucial edge

www.newscientist.com/article/2492...
mRNA drugs could protect against almost any kind of viral infection
mRNA drugs might be able to protect against a huge range of viruses by turning on key parts of our innate defences against infection
www.newscientist.com
Reposted by Michael Le Page
mattneville.bsky.social
If you saw preprint, biggest two updates are: Much improved discussion + variant calls now accessible

If you'd like an accessible summary check out this great article from @mjflepage.bsky.social in New Scientist:

For science thread read on! [2/n]
institutions.newscientist.com/article/2499...
institutions.newscientist.com
mjflepage.bsky.social
Now @r-rahbari.bsky.social @mattneville.bsky.social & co have used a new technique to sequence more 100,000 sperm from 81 men, and have found this phenomenon is more widespread than expected

“The size of the effect across the genome was much higher than any of us thought,” says Neville
mjflepage.bsky.social
This phenomenon was first discovered in 2003 by researchers studying conditions such as achondroplasia, or dwarfism, which are much more common than would be expected due to random mutations 🧬

I wrote a feature about it back in 2014 /3

www.newscientist.com/article/mg22...
Testicular time bomb: Older dads' mutant sperm
The clock is always ticking for testicles (Image: Emiliano Ponzi) Every man's sperm is fighting an evolutionary civil war – and over the years, it ups the risk of fathering a child with a geneti...
www.newscientist.com
mjflepage.bsky.social
Because these mutant sperm stem cells produce more of themselves than usual, the number of mutant sperm they produce increases exponentially 📈 over time, rather than linearly as with other mutations than don't affect growth /2
mjflepage.bsky.social
They are "almost like Hermione’s handbag in Harry Potter” 🧙‍♀️

Heiner Linke of the Nobel committee for chemistry describes the designer materials known as metal-organic frameworks that won the Nobel for Richard Robson, Susumu Kitagawa and Omar Yaghi 🧪

www.newscientist.com/article/2499...
Nobel prize in chemistry awarded for work on molecular architecture
Susumu Kitagawa, Richard Robson and Omar Yaghi have been honoured for the development of metal-organic frameworks, porous materials that can capture water or pollutants
www.newscientist.com
mjflepage.bsky.social
There should be no genetic engineering of wildlife, says a motion to be voted on at an IUCN meeting this month 🧪

But many scientists think synthetic biology is crucial to saving biodiversity - for instance, to make corals 🪸 heat tolerant #wildlifeconservation

www.newscientist.com/article/2498...
Would a ban on genetic engineering of wildlife hamper conservation?
Some conservation groups are calling for an effective ban on genetic modification, but others say these technologies are crucial for preserving biodiversity
www.newscientist.com
mjflepage.bsky.social
A study suggests AI could help evade controls on synthesising bioweapons. Here's why this is like doing a fancy Mission Impossible-style bank raid when the vault door has been left open, the alarm is off and the guards are asleep 🧪

www.newscientist.com/article/2498...
Should we worry AI will create deadly bioweapons? Not yet, but one day
AI tools are being used to design proteins and even viruses, leading to fears these could eventually be used to evade bioweapon controls
www.newscientist.com
Reposted by Michael Le Page
rebeccarhelm.bsky.social
I want to tell you a story, and it begins with this VERY WEIRD animal: Meet Thetys vagina...
[a thread 🧵]
📸 m_patton bit.ly/2Mgw8Sf
🌿🧪🦑🐙🌊
tubular clear animal being held near a beach
mjflepage.bsky.social
So it's not going to used for fertility treatments any time soon if ever, and it doesn't help with the shortage of donor eggs, because it consumes eggs rather than generating them. Yes, it's a technical feat but it's unlikely to be much more than that 3/
mjflepage.bsky.social
Because of the serious health problems that many if not most cloned animals have, there's no way this would be safe. What's more, I don't see an obvious route to making it safe 2/
mjflepage.bsky.social
I do think this human egg story is being massively overhyped. To be clear, no eggs have been "generated", "created" or "made" from human skin cells - rather, existing human eggs have been given the DNA from skin cells using a kind of cloning 1/
mjflepage.bsky.social
We've found a master regulator that controls the level of DNA repair 🧬 and thus how fast we accumulate mutations 🧪

The team that discovered it thinks this also determines the rate of ageing 👵, but they haven't quite proved it yet

www.newscientist.com/article/2497...
How fast you age may be controlled by a DNA repair boss in your cells
When a key protein regulator dials down DNA repair mechanisms, our cells accumulate more mutations, which may cause us to age faster
www.newscientist.com
Reposted by Michael Le Page
parodypm.bsky.social
As Reform's Nathan Gill admits taking bribes from Russian 'secret service pawn' Oleg Voloshyn, here’s a nice photo of Nigel Farage with Voloshyn’s wife.
Reposted by Michael Le Page
janrosenow.bsky.social
Critics of renewables often point to land use as a reason not to invest in wind & solar. Land use IS a real issue for all energy assets incl renewables (unless on-site).

But what critics conveniently forget is the huge land impact of fossil fuels. Aerial view of fracking sites in Wickett, Texas. 👇
mjflepage.bsky.social
Changing the choices on offer at any one time can make people eat climate-friendlier, healthier foods 🍱 without them even realising 🧪

In a trial at a university canteen, the carbon footprint of meals was reduced by a third with no recipe changes

www.newscientist.com/article/2496...
Simple menu tweak can nudge people into choosing climate-friendly food
Rejigging the meal choices on offer in a canteen can prompt people to make healthier, climate-friendlier decisions
www.newscientist.com