@mjlau.bsky.social
Reposted
Online now: Systems analysis of clinical malaria reveals proteomic perturbation and innate-adaptive crosstalk linked to disease severity
Systems analysis of clinical malaria reveals proteomic perturbation and innate-adaptive crosstalk linked to disease severity
While the immune response to Plasmodium falciparum malaria has been studied extensively, the circulating proteome and its cellular origins remain poorly characterized. Lautenbach et al. address this by integrating plasma proteomics and single-cell RNA-seq in 72 patients, revealing molecular patterns linked to disease severity, immune regulation, and tissue origin in malaria.
dlvr.it
July 14, 2025 at 2:48 PM
Online now: Systems analysis of clinical malaria reveals proteomic perturbation and innate-adaptive crosstalk linked to disease severity
Reposted
Proud co‑author on @cp-immunity.bsky.social study by Julius Lautenbach, @chrissundling.bsky.social & Team Färnert w/ HPA & @scilifelab.se. We integrate plasma proteome dynamics (1500 proteins) + scRNA-seq in acute malaria, identifying severity markers & exploring immune-cell communication.
Systems analysis of clinical malaria reveals proteomic perturbation and innate-adaptive crosstalk linked to disease severity
While the immune response to Plasmodium falciparum malaria has been studied extensively,
the circulating proteome and its cellular origins remain poorly characterized. Lautenbach
et al. address this b...
www.cell.com
July 16, 2025 at 10:34 AM
Proud co‑author on @cp-immunity.bsky.social study by Julius Lautenbach, @chrissundling.bsky.social & Team Färnert w/ HPA & @scilifelab.se. We integrate plasma proteome dynamics (1500 proteins) + scRNA-seq in acute malaria, identifying severity markers & exploring immune-cell communication.