Mitchell Kronenberg
@mkronenb.bsky.social
Scientist at La Jolla Institute for Immunology
Here is a link (rdcu.be/edIj3) to new work from our lab to understand how common gene differences affect the risk for for Crohn's disease. The DICE project results suggested a T cell defect, but here we proved it showing promoter effects on T cell metabolism and function
Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function
Nature Communications - Prior studies implicate an allele near laccase domain containing 1 (LACC1) for risk of Crohn’s disease and decreased LACC1 expression in T cells. Using human genome...
rdcu.be
March 18, 2025 at 1:34 AM
Here is a link (rdcu.be/edIj3) to new work from our lab to understand how common gene differences affect the risk for for Crohn's disease. The DICE project results suggested a T cell defect, but here we proved it showing promoter effects on T cell metabolism and function