#ResultatScientifique 🔎| Et si les phages, ces virus des bactéries, pouvaient infecter plusieurs espèces à la fois et remodeler l’écologie microbienne ? 🦠
✍️ Martial Marbouty
📕 @natmicrobiol.nature.com | buff.ly/1R9kqjv

Thanks Meren !! Coming from you … I am honoured !!

New paper!
We generated and/or (re)analyzed ~100 #metagenomics Hi-C datasets to provide a comprehensive analysis of bacterial and viral metagenomes across VERY different environments.
Congratulations to all authors especially Amaury Bignaud and @mmarbout.bsky.social for the huge work!
#metaHiC

Our work show that phages with a broad host ranges are common across ecosystems. It also highlights the interest of using HiC to study single metagenomic samples.
Congrats to all authors !! 🎉

We then show that among the phages with an assigned host, a substantial proportion of them interact with several, and sometimes distantly related, hosts.

We have been able to reconstruct numerous good quality viral genomes up to 1Mb from diverse families such as Megaviricetes or Caudoviricetes.

We then apply our approach on public and newly generated metaHiC datasets (111 in total) from different ecosystems to explore the virosphere of these communities.

We first used a synthetic community composed of various microorganisms and mobile genetic elements to develop a new version of our MetaTOR pipeline allowing to reconstruct virus genomes and identify their hosts in microbial communities.

github.com/koszullab/me...

You like phages ? In this publication, we use metaHiC and our new version of the MetaTOR pipeline to challenge the traditional view of phages with a narrow host range.
@rkoszul.bsky.social @natmicrobiol.nature.com @cnrs.fr @institutpasteur.bsky.social

www.nature.com/articles/s41...

Reportage de @celineloozen.bsky.social > Itw de Martial Marbouty, chercheur CNRS au laboratoire Régulation Spatiale des Génomes de l'Institut Pasteur sur l’étude des interactions phages-bactéries tinyurl.com/m9uxwjct #ScienceCQFD

#Podcast du jour. Virus bactériophages : découverts début XXe s, ils ont été délaissés dans la lutte antibactérienne au profit des antibiotiques. Face à l’antibiorésistance, les bactériophages pourraient-ils faire leur grand retour ? tinyurl.com/yoat4jcu avec Anne Chevallereau et Jérôme Gabard

Great science, great discussions, amazing people… a real pleasure to be here !!