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Mutant Mouse Resource & Research Centers (MMRRC)

@mmrrc.bsky.social

120 followers 170 following 46 posts

An NIH-funded consortium, providing a national repository for genetically engineered mouse strains and embryonic stem cell lines. Researchers worldwide can access these high-quality, well-characterized mouse models to advance studies.

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Nov 19

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 2d

Congratulations to Drs. Brunkow, Ramsdell, & Sakaguchi! For More information: https://postly.click/ECH

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 5d

“...the first step out of the maze for young men begins by reasserting to them the virtue of hard work — an often grueling but indispensable part of finding the right answers in science.”

Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 20d

Some good research "food for thought... " https://www.nature.com/articles/d41586-025-02920-0?utm_source=Live+Audience&utm_campaign=b2c87a0562-nature-briefing-daily-20250916&utm_medium=email&utm_term=0_-33f35e09ea-49915704

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · 23d

🌟 We’re proud to support the Rare Diseases Are Not Rare! Challenge—working together for faster treatments.
With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: https://www.challenge.gov/?challenge=rare-diseases-are-not-rare-2025-challenge

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Sep 2

We're taking efforts to improve the information of new strains at the MMRRC, with our new Strain Quality Control. To view an example of one, visit this strain: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=75745#gene_info_Strain_Quality_Control

MMRRC:075745-JAX

Strain Detail Sheet for C57BL/6-<i>Clptm1<sup>tm1a(KOMP)Wtsi</i></sup>/AmcrMmjax

www.mmrrc.org

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Jul 17

"To be clear, there is no replacement yet for animal research in biomedical science...it remains to be seen how faithfully these [stem cell] reprogrammed cells and organoids mimic various complex biological processes.

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Jul 7

Mice treated with a copper drug repaired faulty brain proteins, reversing Parkinson’s symptoms and offering new hope. Source: https://www.goodnewsnetwork.org/scientists-reverse-parkinsons-symptoms-in-mice-we-were-astonished-by-the-success/

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Jun 13

What happens when lifesaving research quietly disappears? A look at critical NIH-funded projects lost to sudden budget cuts: projects.propublica.org/nih-cuts-res...

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · May 29

Imagine a future where the smell of menthol could alleviate some of the worst symptoms of Alzheimer’s disease. Read More: https://theconversation.com/when-mice-with-alzheimers-inhaled-menthol-their-cognitive-abilities-improved-230330

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · May 20

Scientists used gene-edited mice to test a custom therapy for a deadly infant liver disease—then saved a real child! (P.S., A MMRRC Center Director is an author on this paper!) Source: www.nejm.org/doi/full/10....

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · May 16

Food for thought - "There’s no mystery to innovation and economic growth; the US must nurture its scientists or find out the hard way.

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · May 14

Something different: 3D-printing inside a living mouse’s bladder using sound waves! No cuts. Just ultrasound. Curious? Find out in Science: www.science.org/doi/10.1126/...

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · May 7

Scientists can now guide how cells self-organize using internal forces. Imagine using this to grow tissues in mice faster to test new therapies. Source: journals.aps.org/prl/abstract/10.1103/PhysRevLett.134.148301

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Apr 28

Mouse studies reveal gut viruses help antibiotics — without them, bacteria resist treatment. 🐭🦠Source: cell.com/cell-host-microbe/abstract/S1931-3128(25)00135-0

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Apr 14

Sweden launches PROMISE, a national initiative to integrate large-scale multi-omics data with healthcare and research. By bridging fragmented datasets and improving data access, Sweden aims to unlock the full potential of precision medicine.

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Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Apr 11

As federal funding cuts threaten to stall vital research into conditions like Alzheimer's, diabetes, and endometriosis, we're here to continue our support for America as a foundation for research excellence.

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Apr 11

In an era where chronic illnesses are on the rise and research funding faces unprecedented challenges, the role of the MMRRC has never been more critical.

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Apr 7

A new webinar is coming regarding how ambient temperature affects metabolic rate, concepts of a thermoneutral zone vs thermoneutral points, and much more! physiology.org/detail/event/2025/05/06/default-calendar/understanding-body-temperature-and-energy-homeostasis-in-mice?SSO=Y&_zs=qQHNW&_zl=2imS4

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Apr 3

For the full NIH announcement: https://www.nih.gov/news-events/news-releases/jay-bhattacharya-begins-tenure-18th-director-national-institutes-health

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Apr 3

Sharing a message from the new NIH director regarding direction and aims. We hope to look at these goals to support researchers worldwide with the efforts we're known for and our desire to propel research forward.

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Mar 31

Biotech worries as FDA's Peter Marks retires—key voice in gene therapy, vaccines, and biologics regulation. Source: www.genengnews.com/topics/drug-...

Industry Voices Alarm as Peter Marks Departs FDA

The sudden departure of Peter Marks, MD, from the FDA has prompted a chorus of criticism and despair from industry leaders and trade organizations.

www.genengnews.com

Mutant Mouse Resource & Research Centers (MMRRC) @mmrrc.bsky.social · Mar 27

We want to thank Dr. Green for the 15 years of service he's provided to both our country and to research endeavors worldwide. fiercebiotech.com/biotech/director-nihs-national-human-genome-research-institute-steps-down

UPDATE: Director of National Human Genome Research Institute departs in another Trump admin shakeup

Updated March 21.After serving as the director of the National Human Genome Research Institute (NHGRI) for more than 15 years, Eric Green, M.D., Ph.D., has left his role. | "Eric Green, M.D. Ph.D., is...

fiercebiotech.com