MRC Cognition and Brain Sciences Unit, University of Cambridge
@mrccbu.bsky.social
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Reposted by MRC Cognition and Brain Sciences Unit, University of Cambridge
prashansa.bsky.social
An amazing and rewarding experience at @mrccbu.bsky.social attending COGNESTIC 2025. Something like this at the start of a PhD journey can be extremely helpful in shaping the research. Extremely grateful!
mrccbu.bsky.social
New paper: Mapping the task-general and task-specific neural correlates of speech production: meta-analysis and fMRI direct comparisons of category fluency and picture naming: doi.org/10.1162/IMAG...
mrccbu.bsky.social
New paper - 'Disentangling phonology from phonological short-term memory in Alzheimer’s disease phenotypes': alzres.biomedcentral.com/articles/10....
Disentangling phonology from phonological short-term memory in Alzheimer’s disease phenotypes - Alzheimer's Research & Therapy
Background Impaired phonological short-term memory is a core feature of the logopenic variant of primary progressive aphasia (lvPPA), but it is not clear whether a core phonological processing deficit is also present. Methods We asked three questions: (i) beyond short-term memory impairment, do lvPPA patients have an impairment within phonology itself?; (ii) is their performance in working memory and naming reflective of this phonological impairment?; and (iii) is their repetition performance related to structural and functional differences in key language-dominant regions? We compared non-word and word repetition and short-term memory performance in patients with typical Alzheimer’s disease (tAD), lvPPA per consensus criteria, and others who previously satisfied definitions of lvPPA but had progressed with multi-domain cognitive impairments (lvPPA+). Results Bayesian analyses revealed no group differences in phonological tasks of word and non-word repetition. We found very strong evidence for an effect of self-reported hearing loss on word and non-word repetition, but not multi-syllabic word/phrase repetition. A comparison of phonological versus working memory and naming tasks produced either no evidence or evidence for no correlation. Beyond the expected grey matter reductions in patients relative to controls, there was anecdotal evidence for an association between non-word repetition and functional connectivity between dorsal premotor and posterior superior temporal gyrus regions in patients. Conclusions Our results indicated that, in the absence of self-reported hearing loss, patients did not exhibit impairments in tasks tapping “pure” phonological processing. Our results suggest that instead of having a core phonological impairment, lvPPA patients have a working memory/buffering impairment.
alzres.biomedcentral.com
Reposted by MRC Cognition and Brain Sciences Unit, University of Cambridge
mrccbu.bsky.social
It was hard to say goodbye after two intense and exciting weeks at COGNESTIC 2025. Thank you to all our attendees for making it such a fantastic event. From fMRI to football, EEG/MEG to electric golf, we enjoyed every moment of science, ideas, networking, and fun — even the sun joined in.
mrccbu.bsky.social
Many mental health conditions are associated with increased metabolic morbidity and mortality–why? We propose a model of interoceptive allostasis explaining how mental-metabolic comorbidity can occur and propagate through a vicious cycle of energy dysregulation: www.science.org/doi/10.1126/...
mrccbu.bsky.social
New study led by David Whiteside shows that people with semantic dementia have significant brain volume loss before the onset of symptoms, and that a mild semantic problems across multiple domains can be detected in the early symptomatic phase: doi.org/10.1093/brai...
The presymptomatic and early manifestations of semantic dementia
Whiteside et al. find that brain imaging can reveal temporal lobe atrophy related to semantic dementia around 3–5 years before symptom onset. Whereas clini
doi.org
Reposted by MRC Cognition and Brain Sciences Unit, University of Cambridge
olafhauk.bsky.social
The second week of #COGNESTIC starts with Petar Raykov's @praykov.bsky.social "fMRI Connectivity I". I've never seen the @mrccbu.bsky.social's lecture theatre this full on a Monday morning 😉
Reposted by MRC Cognition and Brain Sciences Unit, University of Cambridge
olafhauk.bsky.social
Followed by "fMRI Connectivity II" by no other than @mrccbu.bsky.social's Rik Henson @rhens.bsky.social.
Reposted by MRC Cognition and Brain Sciences Unit, University of Cambridge
cogbooster.bsky.social
Luca Serrière, José Gomes, and Xingnan Zhao are at the University of Cambridge for #COGNESTIC 2025, an immersive training at the @mrccbu.bsky.social to boost skills in cognitive neuroimaging!🧠
mrccbu.bsky.social
New paper: DECRYPT trial (onlinelibrary.wiley.com/doi/epdf/10....) for youth (8-17) with PTSD following multiple traumas. Cognitive Therapy was superior to treatment-as-usual at 11-month follow-up & improved anxiety/depression.
mrccbu.bsky.social
Does what you eat really shape your brain, and mental health? Or is it the other way around? Come discover how metabolism links body, brain, and mood with @camillanord.bsky.social at the Arches London Bridge for a SeedTalk on 30 September www.eventbrite.co.uk/e/metabolism...
Reposted by MRC Cognition and Brain Sciences Unit, University of Cambridge
olafhauk.bsky.social
Here we go again - a room full of attendees from all over the world at #COGNESTIC 2025, excited to learn about #neuroimaging analysis. Kshipra Gurunandan starts it off with a Primer to #Python. @mrccbu.bsky.social
mrccbu.bsky.social
New fMRI study shows the hippocampus signals mismatches only when our expectations are based on episodic memories — not general knowledge. Challenges theories of the hippocampus as a domain-general comparator. We also explore how brain networks respond to surprise: doi.org/10.1101/2025...
mrccbu.bsky.social
New CamCAN paper led by @noham-wolpe.bsky.social shows that older adults’ tendency to see facial expressions as more positive may not be the adaptive “rose-coloured glasses” we thought, but could signal early cognitive decline and neurodegeneration: pubmed.ncbi.nlm.nih.gov/40854689/
mrccbu.bsky.social
New study from Cam-CAN using 11 different white matter (WM) measures shows WM health is multidimensional—4 latent MRI-derived factors explain 89% of WM variance, linking brain microstructure to vascular health & cognition: doi.org/10.1038/s415...
Reposted by MRC Cognition and Brain Sciences Unit, University of Cambridge
camneuro.bsky.social
Join us for a 2-day international conference "Interventions & Recovery"🧠 bit.ly/46QQ1WG
We'll cover cell & gene therapies, pharmaceutical innovations, and cutting-edge neurotechnology

Check out our Programme!👇https://neuroscience.cam.ac.uk/camneuro-events/8th-cambridge-neuroscience-symposium/?tab=2
mrccbu.bsky.social
In this paper, we measured three neural responses (eCAP, eABR, eASSR) to stimulation with #cochlearimplant using the same stimulus to disentangle the effects of response type and of stimulus type on neural response properties: doi.org/10.1016/j.he...
mrccbu.bsky.social
International study shows that higher levels of education do not reduce rates of cognitive and brain decline in later years, contrary to views that education protects against such decline: www.nature.com/articles/s41...
@rhens.bsky.social
Reposted by MRC Cognition and Brain Sciences Unit, University of Cambridge
duncanastle.bsky.social
*New Paper* How genes for IQ shape brain organisation. Amazing work led by Alicja Monaghan @mrccbu.bsky.social reveals 2 ways. First, they’re associated w/ the ‘costs’ of network formation. Second, they define ‘high value’ areas within the network. How she did it…🧵
doi.org/10.1162/IMAG...
Brain wiring economics, network organisation and population-level genomics
Abstract. What role do our genes play in shaping the structural organisation of the living human brain? Across a sample of 2,153 children (9–11 years old), we address this question, focusing on common...
doi.org
mrccbu.bsky.social
Recent research from CamCAN shows that, when pulse pressure, the difference between systolic and diastolic blood pressure, gets too high, it can damage the brain’s “wiring” (white matter), making it harder to think fast and solve puzzles: doi.org/10.1161/HYPE...
@camcan-2010.bsky.social
Reposted by MRC Cognition and Brain Sciences Unit, University of Cambridge
cam.ac.uk
How can AI fast-track the search for better Alzheimer’s treatments?

Zoe Kourtzi from @campsydept.bsky.social used AI to reanalyse a clinical trial and found a group of patients who responded – showing 46% slower cognitive decline.

Find out more 👇
bit.ly/3GPUgHu
MRI brain scan of a patient progressing rapidly to Alzheimer’s disease.
Reposted by MRC Cognition and Brain Sciences Unit, University of Cambridge
orbenamy.bsky.social
I'm hiring 2+ 2.5-year postdocs over the next few months.

Job 1: looking for someone with deep expertise in computational modelling (reinforcement learning, agent based modelling) on real-world/complex data (closing: 18 August, starting: October-December), www.jobs.cam.ac.uk/job/52059/