@naimhsn.bsky.social
Reposted
Researchers at @pmresearch-uhn.bsky.social have discovered how a molecule called palmitoyl-CoA acts as an “off switch” for a key fungal enzyme that makes fatty acids.
This finding could inform the development of more effective #antifungal therapies.
🔗Read the full study: doi.org/10.1016/j.st...
This finding could inform the development of more effective #antifungal therapies.
🔗Read the full study: doi.org/10.1016/j.st...
Redirecting
doi.org
October 8, 2025 at 7:38 PM
Researchers at @pmresearch-uhn.bsky.social have discovered how a molecule called palmitoyl-CoA acts as an “off switch” for a key fungal enzyme that makes fatty acids.
This finding could inform the development of more effective #antifungal therapies.
🔗Read the full study: doi.org/10.1016/j.st...
This finding could inform the development of more effective #antifungal therapies.
🔗Read the full study: doi.org/10.1016/j.st...
✨ Excited to share our new publication in Structure!
In our study, we discovered a previously unknown allosteric site on FAS. We show that palmitoyl-CoA binds this site to suppress catalytic activity, acting as a molecular “off switch.”
www.sciencedirect.com/science/arti...
In our study, we discovered a previously unknown allosteric site on FAS. We show that palmitoyl-CoA binds this site to suppress catalytic activity, acting as a molecular “off switch.”
www.sciencedirect.com/science/arti...
Allosteric regulation of fungal fatty acid synthesis
Mycobiota fatty acid synthases (FASs) catalyze iterative cycles of condensation, dehydration, and reduction to produce saturated fatty acids. Although…
www.sciencedirect.com
October 2, 2025 at 5:35 PM
✨ Excited to share our new publication in Structure!
In our study, we discovered a previously unknown allosteric site on FAS. We show that palmitoyl-CoA binds this site to suppress catalytic activity, acting as a molecular “off switch.”
www.sciencedirect.com/science/arti...
In our study, we discovered a previously unknown allosteric site on FAS. We show that palmitoyl-CoA binds this site to suppress catalytic activity, acting as a molecular “off switch.”
www.sciencedirect.com/science/arti...