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Narayanan Lab @narayananlab.bsky.social · 27d

Our issue on Computational Properties of the Prefrontal Cortex is now:
www.jneurosci.org/content/45/3...

These articles capture some of the incandescence of the CPPC conferences...
narayanan.lab.uiowa.edu/home/cppc2024
cppc.web.ox.ac.uk
accl.psy.vanderbilt.edu/blog/2018/10...

The Journal of Neuroscience: 45 (37)

www.jneurosci.org

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Narayanan Lab @narayananlab.bsky.social · Aug 11

D1FLP mice are now available from JAX!
www.jax.org/strain/039507

Detailed in this paper: pubmed.ncbi.nlm.nih.gov/39701542/

Let us know if they work for you...

039507 - Drd1-Flpo Strain Details

www.jax.org

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Narayanan Lab @narayananlab.bsky.social · Jul 9

Our latest paper predicting PD mortality from ~2 minutes of resting-state EEG : www.medrxiv.org/content/10.1...

Linear predictive coding electroencephalography algorithms predict Parkinson's disease mortality using out-of-sample tests

Background: Parkinson's disease (PD) increases mortality is difficult to predict because of its heterogeneity and the availability of very few reliable which prognostic markers. Objectives: We used el...

www.medrxiv.org

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Narayanan Lab @narayananlab.bsky.social · Jul 4

Our latest work: www.biorxiv.org/content/10.1...

We show that corticostriatal ramping activity can't readily be explained by movements using motion tracking, and that ramping can't readily be explained by reward anticipation in mice performing timing and Pavlovian tasks.

Timing, movement, and reward contributions to prefrontal and striatal ramping activity

Across species, prefrontal and striatal neurons exhibit time-dependent ramping activity, defined as a consistent monotonic change in firing rate across temporal intervals. However, it is unclear if ra...

www.biorxiv.org

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Narayanan Lab @narayananlab.bsky.social · May 21

Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br...

We find that 4 Hz STN stimulation in *humans* changes decision thresholds:

Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
With Rachel Cole and Jim Cavanagh

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Narayanan Lab @narayananlab.bsky.social · May 21

Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br...

We find that 4 Hz STN stimulation in *humans* changes decision thresholds:

Data: narayanan.lab.uiowa.edu and osf.io/hsz3u

Narayanan Lab @narayananlab.bsky.social · May 19

write-up of our amphetamine paper: www.psypost.org/amphetamine-...

Amphetamine scrambles the brain's sense of time by degrading prefrontal neuron coordination

Researchers have found that amphetamine alters how the brain processes time, increasing variability in the activity of neurons that encode temporal information. The study provides insight into how the...

www.psypost.org

Narayanan Lab @narayananlab.bsky.social · May 15

another new preprint from our group on predicting cognitive changes in PD from resting state fMRI: medrxiv.org/content/10.1...

| medRxiv

medRxiv - The Preprint Server for Health Sciences

https://medrxiv.org/content/10.1101/2025.05.13.25327462v1…

Narayanan Lab @narayananlab.bsky.social · May 14

Our latest preprint on projection-specific tracing of prefrontal activity: www.biorxiv.org/cgi/content/...

Diverse activity in prefrontal projections promotes temporal control of action

Prefrontal neurons can have diverse activity during cognitive functions like working memory, attention, and timing; however, the importance of this heterogeneity is unclear. Our goal was to better und...

www.biorxiv.org

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Narayanan Lab @narayananlab.bsky.social · May 14

Lots more details in the paper. This paper challenged our fundamental view of what we think amphetamine does…

Narayanan Lab @narayananlab.bsky.social · May 14

Amphetamine has been thought to reliably affect timing accuracy. We find in a meta-analysis and in our data that it actually more reliably affects precision:

Narayanan Lab @narayananlab.bsky.social · May 14

Our work showing that amphetamine affects behavior by degrading prefrontal temporal variability is now out at Neuropharmacology: doi.org/10.1016/j.ne...

Work by Matthew Weber and colleagues:

As always, data and code at: narayanan.lab.uiowa.edu/datasets

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Narayanan Lab @narayananlab.bsky.social · Apr 3

That's us!

Narayanan Lab @narayananlab.bsky.social · Apr 3

New preprint from our group showing that drugs that enhance glycolysis slow neurodegeneration in Alzheimer's disease - data from yeast to humans:
www.biorxiv.org/content/10.1...
data: bit.ly/GlycolysisANDAD
Data and code : narayanan.lab.uiowa.edu/home/data

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Narayanan Lab @narayananlab.bsky.social · Apr 2

Congrats - awesome work - George A would have read this with interest!

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Narayanan Lab @narayananlab.bsky.social · Mar 12

What a great looking lab! Best of luck to Mackenzie Rysted at the University of Indiana...

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Narayanan Lab @narayananlab.bsky.social · Mar 3

Congrats!

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Narayanan Lab @narayananlab.bsky.social · Feb 9

May I also suggest contacting your disease-specific patient advocacy organization? For instance, I work in Parkinson's disease - and there are several societies with thousands of members here in Iowa. They need to understand the concrete impacts on patients suffering from Parkinson's disease.

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Narayanan Lab @narayananlab.bsky.social · Jan 16

How do we explain these results? We collaborated Rodica Curtu in math who implemented classic drift diffusion models. These DDMs suggest that D1 and D2 neurons provide temporal evidence. Disrupting them decreases the accumulation of temporal evidence – and predicts slowed timing.

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Narayanan Lab @narayananlab.bsky.social · Jan 16

We’ve previously reported that striatal neuron encode time by linear changes over a temporal interval – and we found that these linear changes in the striatum. However – to our complete surprise – D1 and D2 neurons had *opposite patterns* of ramping!

4/5

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Narayanan Lab @narayananlab.bsky.social · Jan 16

In line with our pharmacology data, we found that optogenetically inactivating either D2 or D1 MSNs slowed temporal control of action:
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Narayanan Lab @narayananlab.bsky.social · Jan 16

This works starts pharmacology showing that dopamine controls the timing of movement. Our work with blocking dopamine receptors systemically – and where they are most abundantly expressed – in the striatum -shows that blocking either D1 or D2 dopamine receptors slows temporal control of action:

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Narayanan Lab @narayananlab.bsky.social · Jan 16

Our latest work is up as a version of record on eLife.

elifesciences.org/articles/96287

This story a long road – but is a major advance on understanding temporal control of action.

As always, data and code are available at narayanan.lab.uiowa.edu/data
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Narayanan Lab @narayananlab.bsky.social · Dec 20

Long story short - we get great expression, and about what we might get from Cre mice. This will be a powerful tool for studying these circuits.

They will be up at Jackson (039507) soon.

Narayanan Lab @narayananlab.bsky.social · Dec 20

Youngcho integrated FlpO - another conditional expression construct - into the D1 gene. This is distinct from the D1 Cre mice, which uses BAC transgenics:

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